KEGG   NETWORK: N00926
Entry
N00926                      Network                                

Name
Escherichia Tir to TLR2/4-MAPK signaling pathway
Definition
Tir -> SHP1/2 -| (TRAF6+TAK1+TAB2) -> (MEK,MKK3/6,MKK4/7) -> (ERK,p38,JNK) -> AP1 => (TNF,IL6)
  Expanded
K12784 -> (5777+5781) -| (7189+6885+23118) -> (5604,5605,5606,5608,6416,5609) -> (5594,5595,1432,5600,5603,6300,5599,5601,5602) -> (2353,3725) => (7124,3569)
Class
nt06121 TLR signaling (viruses and bacteria)
Type
Pathogen
Pathway
hsa05130  Pathogenic Escherichia coli infection
Disease
H00277  Enterohemorrhagic Escherichia coli (EHEC) infection
H00278  Enteropathogenic Escherichia coli (EPEC) infection
Gene
5777  PTPN6; protein tyrosine phosphatase non-receptor type 6
5781  PTPN11; protein tyrosine phosphatase non-receptor type 11
7189  TRAF6; TNF receptor associated factor 6
6885  MAP3K7; mitogen-activated protein kinase kinase kinase 7
23118  TAB2; TGF-beta activated kinase 1 (MAP3K7) binding protein 2
5604  MAP2K1; mitogen-activated protein kinase kinase 1
5605  MAP2K2; mitogen-activated protein kinase kinase 2
5606  MAP2K3; mitogen-activated protein kinase kinase 3
5608  MAP2K6; mitogen-activated protein kinase kinase 6
6416  MAP2K4; mitogen-activated protein kinase kinase 4
5609  MAP2K7; mitogen-activated protein kinase kinase 7
5594  MAPK1; mitogen-activated protein kinase 1
5595  MAPK3; mitogen-activated protein kinase 3
1432  MAPK14; mitogen-activated protein kinase 14
5600  MAPK11; mitogen-activated protein kinase 11
5603  MAPK13; mitogen-activated protein kinase 13
6300  MAPK12; mitogen-activated protein kinase 12
5599  MAPK8; mitogen-activated protein kinase 8
5601  MAPK9; mitogen-activated protein kinase 9
5602  MAPK10; mitogen-activated protein kinase 10
2353  FOS; Fos proto-oncogene, AP-1 transcription factor subunit
3725  JUN; Jun proto-oncogene, AP-1 transcription factor subunit
7124  TNF; tumor necrosis factor
3569  IL6; interleukin 6
Perturbant
K12784 (Tir)  tir; translocated intimin receptor
Reference
  Authors
Yan D, Wang X, Luo L, Cao X, Ge B
  Title
Inhibition of TLR signaling by a bacterial protein containing immunoreceptor tyrosine-based inhibitory motifs.
  Journal
Nat Immunol 13:1063-71 (2012)
DOI:10.1038/ni.2417

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