KEGG   NETWORK: N00927
Entry
N00927                      Network                                

Name
Escherichia/Shigella NleE/OspZ to TNF-NFKB signaling pathway
Definition
NleE -| (TAB2/3) -> IKK -> NFKBIA -> NFKB => CXCL8
  Expanded
K23654 -| (23118,257397) -> (1147+3551+8517) -> 4792 -> (4790+5970) => 3576
Class
nt06123 TNF signaling (viruses and bacteria)
Type
Pathogen
Pathway
hsa05130  Pathogenic Escherichia coli infection
hsa05131  Shigellosis
Disease
H00277  Enterohemorrhagic Escherichia coli (EHEC) infection
H00278  Enteropathogenic Escherichia coli (EPEC) infection
H00299  Shigellosis
Gene
23118  TAB2; TGF-beta activated kinase 1 (MAP3K7) binding protein 2
257397  TAB3; TGF-beta activated kinase 1 (MAP3K7) binding protein 3
1147  CHUK; component of inhibitor of nuclear factor kappa B kinase complex
3551  IKBKB; inhibitor of nuclear factor kappa B kinase subunit beta
8517  IKBKG; inhibitor of nuclear factor kappa B kinase regulatory subunit gamma
4792  NFKBIA; NFKB inhibitor alpha
4790  NFKB1; nuclear factor kappa B subunit 1
5970  RELA; RELA proto-oncogene, NF-kB subunit
3576  CXCL8; C-X-C motif chemokine ligand 8
Perturbant
K23654 (NleE)  nleE; T3SS secreted effector NleE
Reference
  Authors
Zhang L, Ding X, Cui J, Xu H, Chen J, Gong YN, Hu L, Zhou Y, Ge J, Lu Q, Liu L, Chen S, Shao F
  Title
Cysteine methylation disrupts ubiquitin-chain sensing in NF-kappaB activation.
  Journal
Nature 481:204-8 (2011)
DOI:10.1038/nature10690
Reference
  Authors
Ruchaud-Sparagano MH, Muhlen S, Dean P, Kenny B
  Title
The enteropathogenic E. coli (EPEC) Tir effector inhibits NF-kappaB activity by targeting TNFalpha receptor-associated factors.
  Journal
PLoS Pathog 7:e1002414 (2011)
DOI:10.1371/journal.ppat.1002414
Reference
  Authors
Zhang Y, Muhlen S, Oates CV, Pearson JS, Hartland EL
  Title
Identification of a Distinct Substrate-binding Domain in the Bacterial Cysteine Methyltransferase Effectors NleE and OspZ.
  Journal
J Biol Chem 291:20149-62 (2016)
DOI:10.1074/jbc.M116.734079

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