KEGG   NETWORK: N00928
Entry
N00928                      Network                                

Name
Escherichia NleB to TNF-NFKB signaling pathway
Definition
NleB -| GAPDH -> (RIPK1+TRAF2) -> (TAB1/2/3+TAK1) -> IKK -> NFKBIA -> NFKB
  Expanded
K23657 -| 2597 -> (8737+7186) -> ((10454,23118,257397)+6885) -> (1147+3551+8517) -> 4792 -> (4790+5970)
Class
nt06123 TNF signaling (viruses and bacteria)
Type
Pathogen
Pathway
hsa05130  Pathogenic Escherichia coli infection
Disease
H00277  Enterohemorrhagic Escherichia coli (EHEC) infection
H00278  Enteropathogenic Escherichia coli (EPEC) infection
Gene
2597  GAPDH; glyceraldehyde-3-phosphate dehydrogenase
8737  RIPK1; receptor interacting serine/threonine kinase 1
7186  TRAF2; TNF receptor associated factor 2
10454  TAB1; TGF-beta activated kinase 1 (MAP3K7) binding protein 1
23118  TAB2; TGF-beta activated kinase 1 (MAP3K7) binding protein 2
257397  TAB3; TGF-beta activated kinase 1 (MAP3K7) binding protein 3
6885  MAP3K7; mitogen-activated protein kinase kinase kinase 7
1147  CHUK; component of inhibitor of nuclear factor kappa B kinase complex
3551  IKBKB; inhibitor of nuclear factor kappa B kinase subunit beta
8517  IKBKG; inhibitor of nuclear factor kappa B kinase regulatory subunit gamma
4792  NFKBIA; NFKB inhibitor alpha
4790  NFKB1; nuclear factor kappa B subunit 1
5970  RELA; RELA proto-oncogene, NF-kB subunit
Perturbant
K23657 (NleB)  nleB; T3SS secreted effector NleB
Reference
  Authors
Gao X, Wang X, Pham TH, Feuerbacher LA, Lubos ML, Huang M, Olsen R, Mushegian A, Slawson C, Hardwidge PR
  Title
NleB, a bacterial effector with glycosyltransferase activity, targets GAPDH function to inhibit NF-kappaB activation.
  Journal
Cell Host Microbe 13:87-99 (2013)
DOI:10.1016/j.chom.2012.11.010

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