KEGG   NETWORK: N00945
Entry
N00945                      Network                                

Name
Shigella IpaH1.4/2.5 to TNF-NFKB signaling pathway
Definition
IpaH1.4/2.5 -| RFN31 -> RIPK1 -> (TAB1/2/3+TAK1) -> IKK -> NFKBIA -> NFKB
  Expanded
K23828 -| 55072 -> 8737 -> ((10454,23118,257397)+6885) -> (1147+3551+8517) -> 4792 -> (4790+5970)
Class
nt06123 TNF signaling (viruses and bacteria)
Type
Pathogen
Pathway
hsa05131  Shigellosis
Disease
H00299  Shigellosis
Gene
55072  RNF31; ring finger protein 31
8737  RIPK1; receptor interacting serine/threonine kinase 1
10454  TAB1; TGF-beta activated kinase 1 (MAP3K7) binding protein 1
23118  TAB2; TGF-beta activated kinase 1 (MAP3K7) binding protein 2
257397  TAB3; TGF-beta activated kinase 1 (MAP3K7) binding protein 3
6885  MAP3K7; mitogen-activated protein kinase kinase kinase 7
1147  CHUK; component of inhibitor of nuclear factor kappa B kinase complex
3551  IKBKB; inhibitor of nuclear factor kappa B kinase subunit beta
8517  IKBKG; inhibitor of nuclear factor kappa B kinase regulatory subunit gamma
4792  NFKBIA; NFKB inhibitor alpha
4790  NFKB1; nuclear factor kappa B subunit 1
5970  RELA; RELA proto-oncogene, NF-kB subunit
Perturbant
K23828 (IpaH1.4/2.5)  ipaH1.4_2.5; E3 ubiquitin-protein ligase IpaH1.4/2.5
Reference
  Authors
de Jong MF, Liu Z, Chen D, Alto NM
  Title
Shigella flexneri suppresses NF-kappaB activation by inhibiting linear ubiquitin chain ligation.
  Journal
Nat Microbiol 1:16084 (2016)
DOI:10.1038/nmicrobiol.2016.84

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