KEGG   NETWORK: N00962
Entry
N00962                      Network                                

Name
Mutation-inactivated ATXN3 to autophagy-vesicle nucleation
Definition
ATXN3* // (BECN1+PIK3C3+ATG14+PIK3R4+AMBRA1) -> PI3P
  Expanded
4287v1 // (8678+5289+22863+30849+55626) -> C04549
Class
nt06413 Autophagy
nt06462 Spinocerebellar ataxia
Type
Variant
Pathway
hsa05017  Spinocerebellar ataxia
Disease
H00063  Spinocerebellar ataxia (SCA)
Gene
4287  ATXN3; ataxin 3
8678  BECN1; beclin 1
5289  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3
22863  ATG14; autophagy related 14
30849  PIK3R4; phosphoinositide-3-kinase regulatory subunit 4
55626  AMBRA1; autophagy and beclin 1 regulator 1
Variant
4287v1  ATXN3 mutation
Metabolite
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
Reference
  Authors
Ashkenazi A, Bento CF, Ricketts T, Vicinanza M, Siddiqi F, Pavel M, Squitieri F, Hardenberg MC, Imarisio S, Menzies FM, Rubinsztein DC
  Title
Polyglutamine tracts regulate autophagy.
  Journal
Autophagy 13:1613-1614 (2017)
DOI:10.1080/15548627.2017.1336278
Reference
  Authors
Chen RH, Chen YH, Huang TY
  Title
Ubiquitin-mediated regulation of autophagy.
  Journal
J Biomed Sci 26:80 (2019)
DOI:10.1186/s12929-019-0569-y

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