KEGG   NETWORK: N01004
Entry
N01004                      Network                                

Name
Mutation-caused aberrant Abeta to VGCC-Ca2+ -apoptotic pathway
Definition
APP* -> Abeta -> VGCC(L-type) -> Ca2+ -- MCU -> Ca2+(mito) -- MPTP -> CYCS
  Expanded
351v1 -> (C16515,C16514) -> (775+776+778+779) -> C00076 -- 90550 -> C00076 -- (7416,7417,7419,291,292,293,83447) -> 54205
Class
nt06410 Calcium signaling
nt06460 Alzheimer disease
Type
Variant
Pathway
hsa05010  Alzheimer disease
Disease
H00056  Alzheimer disease
Gene
351  APP; amyloid beta precursor protein
775  CACNA1C; calcium voltage-gated channel subunit alpha1 C
776  CACNA1D; calcium voltage-gated channel subunit alpha1 D
778  CACNA1F; calcium voltage-gated channel subunit alpha1 F
779  CACNA1S; calcium voltage-gated channel subunit alpha1 S
90550  MCU; mitochondrial calcium uniporter
7416  VDAC1; voltage dependent anion channel 1
7417  VDAC2; voltage dependent anion channel 2
7419  VDAC3; voltage dependent anion channel 3
291  SLC25A4; solute carrier family 25 member 4
292  SLC25A5; solute carrier family 25 member 5
293  SLC25A6; solute carrier family 25 member 6
83447  SLC25A31; solute carrier family 25 member 31
54205  CYCS; cytochrome c, somatic
Variant
351v1 (APP*)  APP mutation
Metabolite
C16515  Beta-amyloid protein 42
C16514  Beta-amyloid protein 40
C00076  Calcium cation
C00076  Calcium cation
Reference
  Authors
Popugaeva E, Pchitskaya E, Bezprozvanny I
  Title
Dysregulation of Intracellular Calcium Signaling in Alzheimer's Disease.
  Journal
Antioxid Redox Signal 29:1176-1188 (2018)
DOI:10.1089/ars.2018.7506

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