KEGG   NETWORK: N01006
Entry
N01006                      Network                                

Name
Mutation-caused aberrant Abeta to VGCC-Ca2+ -apoptotic pathway
Definition
APP* -> Abeta -> PPID -> MPTP -> CYCS
  Expanded
351v1 -> (C16515,C16514) -> 5481 -> (7416,7417,7419,291,292,293,83447) -> 54205
Class
nt06410 Calcium signaling
nt06460 Alzheimer disease
Type
Variant
Pathway
hsa05010  Alzheimer disease
Disease
H00056  Alzheimer disease
Gene
351  APP; amyloid beta precursor protein
5481  PPID; peptidylprolyl isomerase D
7416  VDAC1; voltage dependent anion channel 1
7417  VDAC2; voltage dependent anion channel 2
7419  VDAC3; voltage dependent anion channel 3
291  SLC25A4; solute carrier family 25 member 4
292  SLC25A5; solute carrier family 25 member 5
293  SLC25A6; solute carrier family 25 member 6
83447  SLC25A31; solute carrier family 25 member 31
54205  CYCS; cytochrome c, somatic
Variant
351v1 (APP*)  APP mutation
Metabolite
C16515  Beta-amyloid protein 42
C16514  Beta-amyloid protein 40
Reference
  Authors
Pajak B, Kania E, Orzechowski A
  Title
Killing Me Softly: Connotations to Unfolded Protein Response and Oxidative Stress in Alzheimer's Disease.
  Journal
Oxid Med Cell Longev 2016:1805304 (2016)
DOI:10.1155/2016/1805304
Reference
  Authors
Tan Y, Deng Y, Qing H
  Title
Calcium channel blockers and Alzheimer's disease.
  Journal
Neural Regen Res 7:137-40 (2012)
DOI:10.3969/j.issn.1673-5374.2012.02.010
Reference
  Authors
Du H, Yan SS
  Title
Mitochondrial permeability transition pore in Alzheimer's disease: cyclophilin D and amyloid beta.
  Journal
Biochim Biophys Acta 1802:198-204 (2010)
DOI:10.1016/j.bbadis.2009.07.005

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