KEGG   NETWORK: N01028
Entry
N01028                      Network                                
Name
Mutation-inactivated UCHL1 to UCHL1-mediated hydrolysis
Definition
UB(chain) // UCHL1* // UB(free)
  Expanded
(6233,7311,7314,7316) // 7345v1 // (6233,7311,7314,7316)
Class
nt06463 Parkinson disease
nt06466 Pathways of neurodegeneration
Type
Variant
Pathway
hsa05012  Parkinson disease
Disease
H00057  Parkinson disease
Gene
6233  RPS27A; ribosomal protein S27a
7311  UBA52; ubiquitin A-52 residue ribosomal protein fusion product 1
7314  UBB; ubiquitin B
7316  UBC; ubiquitin C
7345  UCHL1; ubiquitin C-terminal hydrolase L1
Variant
7345v1 (UCHL1*)  UCHL1 mutation
Reference
PMID:12705903
  Authors
Nishikawa K, Li H, Kawamura R, Osaka H, Wang YL, Hara Y, Hirokawa T, Manago Y, Amano T, Noda M, Aoki S, Wada K
  Title
Alterations of structure and hydrolase activity of parkinsonism-associated human ubiquitin carboxyl-terminal hydrolase L1 variants.
  Journal
Biochem Biophys Res Commun 304:176-83 (2003)
DOI:10.1016/s0006-291x(03)00555-2
Reference
PMID:28018215
  Authors
Zheng Q, Huang T, Zhang L, Zhou Y, Luo H, Xu H, Wang X
  Title
Dysregulation of Ubiquitin-Proteasome System in Neurodegenerative Diseases.
  Journal
Front Aging Neurosci 8:303 (2016)
DOI:10.3389/fnagi.2016.00303

  All links  
Pathway (1)   
   KEGG PATHWAY (1)   
Network (1)   
   KEGG VARIANT (1)   
Gene (5)   
   KEGG GENES (5)   
Literature (2)   
   PubMed (2)   
All databases (9)   

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