KEGG   NETWORK: N01039
Entry
N01039                      Network                                

Name
Mutation-inactivated PRKN to DOPAL generation
Definition
PRKN* // MAO -> DOPAL
  Expanded
5071v1 -- (4128,4129) -> C04043
Class
nt06422 Dopamine metabolism
nt06463 Parkinson disease
Type
Variant
Pathway
hsa05012  Parkinson disease
Disease
H00057  Parkinson disease
Gene
5071  PRKN; parkin RBR E3 ubiquitin protein ligase
4128  MAOA; monoamine oxidase A
4129  MAOB; monoamine oxidase B
Variant
5071v1 (PRKN*)  PRKN mutation
Metabolite
C04043  3,4-Dihydroxyphenylacetaldehyde
Reference
  Authors
Itier JM, Ibanez P, Mena MA, Abbas N, Cohen-Salmon C, Bohme GA, Laville M, Pratt J, Corti O, Pradier L, Ret G, Joubert C, Periquet M, Araujo F, Negroni J, Casarejos MJ, Canals S, Solano R, Serrano A, Gallego E, Sanchez M, Denefle P, Benavides J, Tremp G, Rooney TA, Brice A, Garcia de Yebenes J
  Title
Parkin gene inactivation alters behaviour and dopamine neurotransmission in the mouse.
  Journal
Hum Mol Genet 12:2277-91 (2003)
DOI:10.1093/hmg/ddg239
Reference
  Authors
Casarejos MJ, Solano RM, Menendez J, Rodriguez-Navarro JA, Correa C, Garcia de Yebenes J, Mena MA
  Title
Differential effects of l-DOPA on monoamine metabolism, cell survival and glutathione production in midbrain neuronal-enriched cultures from parkin knockout and wild-type mice.
  Journal
J Neurochem 94:1005-14 (2005)
DOI:10.1111/j.1471-4159.2005.03249.x
Reference
  Authors
Naoi M, Riederer P, Maruyama W
  Title
Modulation of monoamine oxidase (MAO) expression in neuropsychiatric disorders: genetic and environmental factors involved in type A MAO expression.
  Journal
J Neural Transm (Vienna) 123:91-106 (2016)
DOI:10.1007/s00702-014-1362-4
Reference
  Authors
Jesko H, Lenkiewicz AM, Wilkaniec A, Adamczyk A
  Title
The interplay between parkin and alpha-synuclein; possible implications for the pathogenesis of Parkinson's disease.
  Journal
Acta Neurobiol Exp (Wars) 79:276-289 (2019)

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