KEGG   NETWORK: N01043
Entry
N01043                      Network                                

Name
Mutation-inactivated PINK1 to electron transfer in Complex I
Definition
PINK1* -| CxI -> Q
  Expanded
65018v1 -| (4535+4536+4537+4538+4540+4541+4719+4720+4722+4724+4725+4726+374291+4728+4723+4729+4731+4694+4695+4696+4697+4698+4700+4701+4702+4704+4705+4706+126328+55967+51079+4707+4708+4709+4710+4711+4712+4713+4714+4715+4716+54539+4717+4718) -> C00399
Class
nt06418 Oxidative phosphorylation
nt06463 Parkinson disease
Type
Variant
Pathway
hsa05012  Parkinson disease
Disease
H00057  Parkinson disease
Gene
65018  PINK1; PTEN induced kinase 1
4535  ND1; NADH dehydrogenase, subunit 1 (complex I)
4536  ND2; MTND2
4537  ND3; NADH dehydrogenase, subunit 3 (complex I)
4538  ND4; NADH dehydrogenase, subunit 4 (complex I)
4540  ND5; NADH dehydrogenase, subunit 5 (complex I)
4541  ND6; NADH dehydrogenase, subunit 6 (complex I)
4719  NDUFS1; NADH:ubiquinone oxidoreductase core subunit S1
4720  NDUFS2; NADH:ubiquinone oxidoreductase core subunit S2
4722  NDUFS3; NADH:ubiquinone oxidoreductase core subunit S3
4724  NDUFS4; NADH:ubiquinone oxidoreductase subunit S4
4725  NDUFS5; NADH:ubiquinone oxidoreductase subunit S5
4726  NDUFS6; NADH:ubiquinone oxidoreductase subunit S6
374291  NDUFS7; NADH:ubiquinone oxidoreductase core subunit S7
4728  NDUFS8; NADH:ubiquinone oxidoreductase core subunit S8
4723  NDUFV1; NADH:ubiquinone oxidoreductase core subunit V1
4729  NDUFV2; NADH:ubiquinone oxidoreductase core subunit V2
4731  NDUFV3; NADH:ubiquinone oxidoreductase subunit V3
4694  NDUFA1; NADH:ubiquinone oxidoreductase subunit A1
4695  NDUFA2; NADH:ubiquinone oxidoreductase subunit A2
4696  NDUFA3; NADH:ubiquinone oxidoreductase subunit A3
4697  NDUFA4; NDUFA4 mitochondrial complex associated
4698  NDUFA5; NADH:ubiquinone oxidoreductase subunit A5
4700  NDUFA6; NADH:ubiquinone oxidoreductase subunit A6
4701  NDUFA7; NADH:ubiquinone oxidoreductase subunit A7
4702  NDUFA8; NADH:ubiquinone oxidoreductase subunit A8
4704  NDUFA9; NADH:ubiquinone oxidoreductase subunit A9
4705  NDUFA10; NADH:ubiquinone oxidoreductase subunit A10
4706  NDUFAB1; NADH:ubiquinone oxidoreductase subunit AB1
126328  NDUFA11; NADH:ubiquinone oxidoreductase subunit A11
55967  NDUFA12; NADH:ubiquinone oxidoreductase subunit A12
51079  NDUFA13; NADH:ubiquinone oxidoreductase subunit A13
4707  NDUFB1; NADH:ubiquinone oxidoreductase subunit B1
4708  NDUFB2; NADH:ubiquinone oxidoreductase subunit B2
4709  NDUFB3; NADH:ubiquinone oxidoreductase subunit B3
4710  NDUFB4; NADH:ubiquinone oxidoreductase subunit B4
4711  NDUFB5; NADH:ubiquinone oxidoreductase subunit B5
4712  NDUFB6; NADH:ubiquinone oxidoreductase subunit B6
4713  NDUFB7; NADH:ubiquinone oxidoreductase subunit B7
4714  NDUFB8; NADH:ubiquinone oxidoreductase subunit B8
4715  NDUFB9; NADH:ubiquinone oxidoreductase subunit B9
4716  NDUFB10; NADH:ubiquinone oxidoreductase subunit B10
54539  NDUFB11; NADH:ubiquinone oxidoreductase subunit B11
4717  NDUFC1; NADH:ubiquinone oxidoreductase subunit C1
4718  NDUFC2; NADH:ubiquinone oxidoreductase subunit C2
Variant
65018v1 (PINK1*)  PINK1 mutation
Metabolite
C00399  Ubiquinone
Reference
  Authors
Franco-Iborra S, Vila M, Perier C
  Title
The Parkinson Disease Mitochondrial Hypothesis: Where Are We at?
  Journal
Neuroscientist 22:266-77 (2016)
DOI:10.1177/1073858415574600
Reference
  Authors
Bose A, Beal MF
  Title
Mitochondrial dysfunction in Parkinson's disease.
  Journal
J Neurochem 139 Suppl 1:216-231 (2016)
DOI:10.1111/jnc.13731
Reference
  Authors
Cali T, Ottolini D, Brini M
  Title
Mitochondria, calcium, and endoplasmic reticulum stress in Parkinson's disease.
  Journal
Biofactors 37:228-40 (2011)
DOI:10.1002/biof.159
Reference
  Authors
Shim JH, Yoon SH, Kim KH, Han JY, Ha JY, Hyun DH, Paek SH, Kang UJ, Zhuang X, Son JH
  Title
The antioxidant Trolox helps recovery from the familial Parkinson's disease-specific mitochondrial deficits caused by PINK1- and DJ-1-deficiency in dopaminergic neuronal cells.
  Journal
Mitochondrion 11:707-15 (2011)
DOI:10.1016/j.mito.2011.05.013
Reference
  Authors
Hoepken HH, Gispert S, Morales B, Wingerter O, Del Turco D, Mulsch A, Nussbaum RL, Muller K, Drose S, Brandt U, Deller T, Wirth B, Kudin AP, Kunz WS, Auburger G
  Title
Mitochondrial dysfunction, peroxidation damage and changes in glutathione metabolism in PARK6.
  Journal
Neurobiol Dis 25:401-11 (2007)
DOI:10.1016/j.nbd.2006.10.007

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