KEGG   NETWORK: N01051
Entry
N01051                      Network                                

Name
Mutation-inactivated DJ1 to intrinsic apoptotic pathway
Definition
DJ1* // BCL2L1 // BAX
  Expanded
11315v1 // 598 // 581
Class
nt06414 Apoptosis
nt06463 Parkinson disease
Type
Variant
Pathway
hsa05012  Parkinson disease
Disease
H00057  Parkinson disease
Gene
11315  PARK7; Parkinsonism associated deglycase
598  BCL2L1; BCL2 like 1
581  BAX; BCL2 associated X, apoptosis regulator
Variant
11315v1 (DJ1*)  PARK7 mutation
Reference
  Authors
Dolgacheva LP, Berezhnov AV, Fedotova EI, Zinchenko VP, Abramov AY
  Title
Role of DJ-1 in the mechanism of pathogenesis of Parkinson's disease.
  Journal
J Bioenerg Biomembr 51:175-188 (2019)
DOI:10.1007/s10863-019-09798-4
Reference
  Authors
Lee MK, Lee MS, Bae DW, Lee DH, Cha SS, Chi SW
  Title
Structural basis for the interaction between DJ-1 and Bcl-XL.
  Journal
Biochem Biophys Res Commun 495:1067-1073 (2018)
DOI:10.1016/j.bbrc.2017.11.129

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