KEGG   NETWORK: N01059
Entry
N01059                      Network                                

Name
Mutation-inactivated DJ1 to KEAP1-NRF2 signaling pathway
Definition
DJ1* // NRF2 // TRX1
  Expanded
11315v1 // 4780 // 7295
Class
nt06440 Transcription
nt06463 Parkinson disease
Type
Variant
Pathway
hsa05012  Parkinson disease
Disease
H00057  Parkinson disease
Gene
11315  PARK7; Parkinsonism associated deglycase
4780  NFE2L2; nuclear factor, erythroid 2 like 2
7295  TXN; thioredoxin
Variant
11315v1 (DJ1*)  PARK7 mutation
Reference
  Authors
Dolgacheva LP, Berezhnov AV, Fedotova EI, Zinchenko VP, Abramov AY
  Title
Role of DJ-1 in the mechanism of pathogenesis of Parkinson's disease.
  Journal
J Bioenerg Biomembr 51:175-188 (2019)
DOI:10.1007/s10863-019-09798-4
Reference
  Authors
Biosa A, Sandrelli F, Beltramini M, Greggio E, Bubacco L, Bisaglia M
  Title
Recent findings on the physiological function of DJ-1: Beyond Parkinson's disease.
  Journal
Neurobiol Dis 108:65-72 (2017)
DOI:10.1016/j.nbd.2017.08.005
Reference
  Authors
Francisqueti-Ferron FV, Ferron AJT, Garcia JL, Silva CCVA, Costa MR, Gregolin CS, Moreto F, Ferreira ALA, Minatel IO, Correa CR
  Title
Basic Concepts on the Role of Nuclear Factor Erythroid-Derived 2-Like 2 (Nrf2) in Age-Related Diseases.
  Journal
Int J Mol Sci 20:E3208 (2019)
DOI:10.3390/ijms20133208

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