KEGG   NETWORK: N01066
Entry
N01066                      Network                                

Name
ARNO-ARF-ACTB_G signaling pathway
Definition
ARNO -> ARF6 -> ARF1 -> (WASF+ABI1+HSPC300+CYFIP+NCKAP1) -> ARP2/3 -> (ACTB,ACTG1)
  Expanded
(27128,9265,9266,9267) -> 382 -> 375 -> ((10163,10810,8936)+10006+55845+(23191,26999)+10787) -> (10097+10096+10552+10095+10109+10094+10093+10092+81873) -> (60,71)
Class
nt06135 Cytoskeletal regulation (viruses and bacteria)
Type
Reference
Gene
27128  CYTH4; cytohesin 4
9265  CYTH3; cytohesin 3
9266  CYTH2; cytohesin 2
9267  CYTH1; cytohesin 1
382  ARF6; ADP ribosylation factor 6
375  ARF1; ADP ribosylation factor 1
10163  WASF2; WASP family member 2
10810  WASF3; WASP family member 3
8936  WASF1; WASP family member 1
10006  ABI1; abl interactor 1
55845  BRK1; BRICK1 subunit of SCAR/WAVE actin nucleating complex
23191  CYFIP1; cytoplasmic FMR1 interacting protein 1
26999  CYFIP2; cytoplasmic FMR1 interacting protein 2
10787  NCKAP1; NCK associated protein 1
10097  ACTR2; actin related protein 2
10096  ACTR3; actin related protein 3
10552  ARPC1A; actin related protein 2/3 complex subunit 1A
10095  ARPC1B; actin related protein 2/3 complex subunit 1B
10109  ARPC2; actin related protein 2/3 complex subunit 2
10094  ARPC3; actin related protein 2/3 complex subunit 3
10093  ARPC4; actin related protein 2/3 complex subunit 4
10092  ARPC5; actin related protein 2/3 complex subunit 5
81873  ARPC5L; actin related protein 2/3 complex subunit 5 like
60  ACTB; actin beta
71  ACTG1; actin gamma 1
Reference
  Authors
Van Acker T, Tavernier J, Peelman F
  Title
The Small GTPase Arf6: An Overview of Its Mechanisms of Action and of Its Role in Host(-)Pathogen Interactions and Innate Immunity.
  Journal
Int J Mol Sci 20:E2209 (2019)
DOI:10.3390/ijms20092209
Reference
  Authors
Humphreys D, Singh V, Koronakis V
  Title
Inhibition of WAVE Regulatory Complex Activation by a Bacterial Virulence Effector Counteracts Pathogen Phagocytosis.
  Journal
Cell Rep 17:697-707 (2016)
DOI:10.1016/j.celrep.2016.09.039
Reference
  Authors
Humphreys D, Davidson A, Hume PJ, Koronakis V
  Title
Salmonella virulence effector SopE and Host GEF ARNO cooperate to recruit and activate WAVE to trigger bacterial invasion.
  Journal
Cell Host Microbe 11:129-39 (2012)
DOI:10.1016/j.chom.2012.01.006

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