KEGG   NETWORK: N01128
Entry
N01128                      Network                                

Name
Salmonella SopE to RAC signaling pathway
Definition
SopE -> RAC1 -> (WASF+ABI1+HSPC300+CYFIP+NCKAP1) -> ARP2/3 -> (ACTB,ACTG1)
  Expanded
K13741 -> 5879 -> ((10163,10810,8936)+10006+55845+(23191,26999)+10787) -> (10097+10096+10552+10095+10109+10094+10093+10092+81873) -> (60,71)
Class
nt06135 Cytoskeletal regulation (viruses and bacteria)
Type
Pathogen
Pathway
hsa05132  Salmonella infection
Disease
H00113  Salmonellosis
Gene
5879  RAC1; Rac family small GTPase 1
10163  WASF2; WASP family member 2
10810  WASF3; WASP family member 3
8936  WASF1; WASP family member 1
10006  ABI1; abl interactor 1
55845  BRK1; BRICK1 subunit of SCAR/WAVE actin nucleating complex
23191  CYFIP1; cytoplasmic FMR1 interacting protein 1
26999  CYFIP2; cytoplasmic FMR1 interacting protein 2
10787  NCKAP1; NCK associated protein 1
10097  ACTR2; actin related protein 2
10096  ACTR3; actin related protein 3
10552  ARPC1A; actin related protein 2/3 complex subunit 1A
10095  ARPC1B; actin related protein 2/3 complex subunit 1B
10109  ARPC2; actin related protein 2/3 complex subunit 2
10094  ARPC3; actin related protein 2/3 complex subunit 3
10093  ARPC4; actin related protein 2/3 complex subunit 4
10092  ARPC5; actin related protein 2/3 complex subunit 5
81873  ARPC5L; actin related protein 2/3 complex subunit 5 like
60  ACTB; actin beta
71  ACTG1; actin gamma 1
Perturbant
K13741 (SopE)  sopE; guanine nucleotide exchange factor SopE
Reference
  Authors
Humphreys D, Davidson A, Hume PJ, Koronakis V
  Title
Salmonella virulence effector SopE and Host GEF ARNO cooperate to recruit and activate WAVE to trigger bacterial invasion.
  Journal
Cell Host Microbe 11:129-39 (2012)
DOI:10.1016/j.chom.2012.01.006
Reference
  Authors
Friebel A, Ilchmann H, Aepfelbacher M, Ehrbar K, Machleidt W, Hardt WD
  Title
SopE and SopE2 from Salmonella typhimurium activate different sets of RhoGTPases of the host cell.
  Journal
J Biol Chem 276:34035-40 (2001)
DOI:10.1074/jbc.M100609200
Reference
  Authors
Van Acker T, Tavernier J, Peelman F
  Title
The Small GTPase Arf6: An Overview of Its Mechanisms of Action and of Its Role in Host(-)Pathogen Interactions and Innate Immunity.
  Journal
Int J Mol Sci 20:E2209 (2019)
DOI:10.3390/ijms20092209

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