KEGG   NETWORK: N01137
Entry
N01137                      Network                                

Name
PINK-Parkin-mediated autophagosome formation
Definition
PINK1 -> PRKN -> (CISD1,CISD2,FAF2,FKBP8,TOMM70,HK1) -- (SQSTM1,OPTN,NDP52,TAX1BP1,NBR1) -- LC3
  Expanded
65018 -> 5071 -> ((55847,493856,23197,23770,9868,3098) -- (8878,10133,10241,8887,4077) -- (11337,23710,11345)
Class
nt06421 Mitophagy
nt06464 Amyotrophic lateral sclerosis
Type
Reference
Pathway
hsa04137  Mitophagy - animal
Gene
65018  PINK1; PTEN induced kinase 1
5071  PRKN; parkin RBR E3 ubiquitin protein ligase
55847  CISD1; CDGSH iron sulfur domain 1
493856  CISD2; CDGSH iron sulfur domain 2
23197  FAF2; Fas associated factor family member 2
23770  FKBP8; FKBP prolyl isomerase 8
9868  TOMM70; translocase of outer mitochondrial membrane 70
3098  HK1; hexokinase 1
8878  SQSTM1; sequestosome 1
10133  OPTN; optineurin
10241  CALCOCO2; calcium binding and coiled-coil domain 2
8887  TAX1BP1; Tax1 binding protein 1
4077  NBR1; NBR1 autophagy cargo receptor
11337  GABARAP; GABA type A receptor-associated protein
23710  GABARAPL1; GABA type A receptor associated protein like 1
11345  GABARAPL2; GABA type A receptor associated protein like 2
Reference
  Authors
Palikaras K, Lionaki E, Tavernarakis N
  Title
Mechanisms of mitophagy in cellular homeostasis, physiology and pathology.
  Journal
Nat Cell Biol 20:1013-1022 (2018)
DOI:10.1038/s41556-018-0176-2
Reference
  Authors
Yoo SM, Jung YK
  Title
A Molecular Approach to Mitophagy and Mitochondrial Dynamics.
  Journal
Mol Cells 41:18-26 (2018)
DOI:10.14348/molcells.2018.2277
Reference
  Authors
Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW
  Title
Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
  Journal
Nature 496:372-6 (2013)
DOI:10.1038/nature12043
Reference
  Authors
Ordureau A, Paulo JA, Zhang W, Ahfeldt T, Zhang J, Cohn EF, Hou Z, Heo JM, Rubin LL, Sidhu SS, Gygi SP, Harper JW
  Title
Dynamics of PARKIN-Dependent Mitochondrial Ubiquitylation in Induced Neurons and Model Systems Revealed by Digital Snapshot Proteomics.
  Journal
Mol Cell 70:211-227.e8 (2018)
DOI:10.1016/j.molcel.2018.03.012
Reference
  Authors
Herhaus L, Dikic I
  Title
Expanding the ubiquitin code through post-translational modification.
  Journal
EMBO Rep 16:1071-83 (2015)
DOI:10.15252/embr.201540891

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