KEGG   NETWORK: N01140
Entry
N01140                      Network                                

Name
TBK1-mediated autophagosome formation
Definition
TBK1 -> (SQSTM1,OPTN,NDP52,TAX1BP1,NBR1) -- LC3
  Expanded
29110 -> (8878,10133,10241,8887,4077) -- (11337,11345,23710)
Class
nt06421 Mitophagy
nt06464 Amyotrophic lateral sclerosis
Type
Reference
Pathway
hsa04137  Mitophagy - animal
Gene
29110  TBK1; TANK binding kinase 1
8878  SQSTM1; sequestosome 1
10133  OPTN; optineurin
10241  CALCOCO2; calcium binding and coiled-coil domain 2
8887  TAX1BP1; Tax1 binding protein 1
4077  NBR1; NBR1 autophagy cargo receptor
11337  GABARAP; GABA type A receptor-associated protein
11345  GABARAPL2; GABA type A receptor associated protein like 2
23710  GABARAPL1; GABA type A receptor associated protein like 1
Reference
  Authors
Herhaus L, Dikic I
  Title
Expanding the ubiquitin code through post-translational modification.
  Journal
EMBO Rep 16:1071-83 (2015)
DOI:10.15252/embr.201540891
Reference
  Authors
Kiriyama Y, Nochi H
  Title
The Function of Autophagy in Neurodegenerative Diseases.
  Journal
Int J Mol Sci 16:26797-812 (2015)
DOI:10.3390/ijms161125990
Reference
  Authors
Richter B, Sliter DA, Herhaus L, Stolz A, Wang C, Beli P, Zaffagnini G, Wild P, Martens S, Wagner SA, Youle RJ, Dikic I
  Title
Phosphorylation of OPTN by TBK1 enhances its binding to Ub chains and promotes selective autophagy of damaged mitochondria.
  Journal
Proc Natl Acad Sci U S A 113:4039-44 (2016)
DOI:10.1073/pnas.1523926113
Reference
  Authors
Matsumoto G, Shimogori T, Hattori N, Nukina N
  Title
TBK1 controls autophagosomal engulfment of polyubiquitinated mitochondria through p62/SQSTM1 phosphorylation.
  Journal
Hum Mol Genet 24:4429-42 (2015)
DOI:10.1093/hmg/ddv179

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