KEGG   NETWORK: N01160
Entry
N01160                      Network                                

Name
Mutation-caused aberrant SOD1 to retrograde axonal transport
Definition
SOD1* -| (DCTN+DNAH+DNAI+DNALI1+DNAL)
  Expanded
6647v1 -| ((1639+10540+11258+51164+84516+10671+(10121,10120)+55860)+(25981,146754,55567,1767,1768,56171,1769,1770,196385,8701,201625,8632)+(27019,64446)+7802+(83544,10126))
Class
nt06419 Microtubule-based transport
nt06464 Amyotrophic lateral sclerosis
Type
Variant
Pathway
hsa05014  Amyotrophic lateral sclerosis
Disease
H00058  Amyotrophic lateral sclerosis (ALS)
Gene
6647  SOD1; superoxide dismutase 1
1639  DCTN1; dynactin subunit 1
10540  DCTN2; dynactin subunit 2
11258  DCTN3; dynactin subunit 3
51164  DCTN4; dynactin subunit 4
84516  DCTN5; dynactin subunit 5
10671  DCTN6; dynactin subunit 6
10121  ACTR1A; actin related protein 1A
10120  ACTR1B; actin related protein 1B
55860  ACTR10; actin related protein 10
25981  DNAH1; dynein axonemal heavy chain 1
146754  DNAH2; dynein axonemal heavy chain 2
55567  DNAH3; dynein axonemal heavy chain 3
1767  DNAH5; dynein axonemal heavy chain 5
1768  DNAH6; dynein axonemal heavy chain 6
56171  DNAH7; dynein axonemal heavy chain 7
1769  DNAH8; dynein axonemal heavy chain 8
1770  DNAH9; dynein axonemal heavy chain 9
196385  DNAH10; dynein axonemal heavy chain 10
8701  DNAH11; dynein axonemal heavy chain 11
201625  DNAH12; dynein axonemal heavy chain 12
8632  DNAH17; dynein axonemal heavy chain 17
27019  DNAI1; dynein axonemal intermediate chain 1
64446  DNAI2; dynein axonemal intermediate chain 2
7802  DNALI1; dynein axonemal light intermediate chain 1
83544  DNAL1; dynein axonemal light chain 1
10126  DNAL4; dynein axonemal light chain 4
Variant
6647v1 (SOD1*)  SOD1 mutation
Reference
  Authors
Zhang F, Strom AL, Fukada K, Lee S, Hayward LJ, Zhu H
  Title
Interaction between familial amyotrophic lateral sclerosis (ALS)-linked SOD1 mutants and the dynein complex.
  Journal
J Biol Chem 282:16691-9 (2007)
DOI:10.1074/jbc.M609743200
Reference
  Authors
Smith EF, Shaw PJ, De Vos KJ
  Title
The role of mitochondria in amyotrophic lateral sclerosis.
  Journal
Neurosci Lett 710:132933 (2019)
DOI:10.1016/j.neulet.2017.06.052
Reference
  Authors
Schon EA, Przedborski S
  Title
Mitochondria: the next (neurode)generation.
  Journal
Neuron 70:1033-53 (2011)
DOI:10.1016/j.neuron.2011.06.003

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