KEGG   Nannospalax galili (Upper Galilee mountains blind mole rat): 103741502
Entry
103741502         CDS       T03372                                 
Symbol
Plcb2
Name
(RefSeq) phospholipase C beta 2
  KO
K05858  phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
ngi  Nannospalax galili (Upper Galilee mountains blind mole rat)
Pathway
ngi00562  Inositol phosphate metabolism
ngi01100  Metabolic pathways
ngi04015  Rap1 signaling pathway
ngi04020  Calcium signaling pathway
ngi04022  cGMP-PKG signaling pathway
ngi04062  Chemokine signaling pathway
ngi04070  Phosphatidylinositol signaling system
ngi04071  Sphingolipid signaling pathway
ngi04072  Phospholipase D signaling pathway
ngi04261  Adrenergic signaling in cardiomyocytes
ngi04270  Vascular smooth muscle contraction
ngi04310  Wnt signaling pathway
ngi04371  Apelin signaling pathway
ngi04540  Gap junction
ngi04611  Platelet activation
ngi04613  Neutrophil extracellular trap formation
ngi04621  NOD-like receptor signaling pathway
ngi04713  Circadian entrainment
ngi04720  Long-term potentiation
ngi04723  Retrograde endocannabinoid signaling
ngi04724  Glutamatergic synapse
ngi04725  Cholinergic synapse
ngi04726  Serotonergic synapse
ngi04728  Dopaminergic synapse
ngi04730  Long-term depression
ngi04742  Taste transduction
ngi04750  Inflammatory mediator regulation of TRP channels
ngi04911  Insulin secretion
ngi04912  GnRH signaling pathway
ngi04915  Estrogen signaling pathway
ngi04916  Melanogenesis
ngi04918  Thyroid hormone synthesis
ngi04919  Thyroid hormone signaling pathway
ngi04921  Oxytocin signaling pathway
ngi04922  Glucagon signaling pathway
ngi04924  Renin secretion
ngi04925  Aldosterone synthesis and secretion
ngi04926  Relaxin signaling pathway
ngi04927  Cortisol synthesis and secretion
ngi04928  Parathyroid hormone synthesis, secretion and action
ngi04929  GnRH secretion
ngi04933  AGE-RAGE signaling pathway in diabetic complications
ngi04934  Cushing syndrome
ngi04935  Growth hormone synthesis, secretion and action
ngi04961  Endocrine and other factor-regulated calcium reabsorption
ngi04970  Salivary secretion
ngi04971  Gastric acid secretion
ngi04972  Pancreatic secretion
ngi04973  Carbohydrate digestion and absorption
ngi05010  Alzheimer disease
ngi05016  Huntington disease
ngi05017  Spinocerebellar ataxia
ngi05022  Pathways of neurodegeneration - multiple diseases
ngi05142  Chagas disease
ngi05143  African trypanosomiasis
ngi05146  Amoebiasis
ngi05163  Human cytomegalovirus infection
ngi05200  Pathways in cancer
ngi05415  Diabetic cardiomyopathy
ngi05417  Lipid and atherosclerosis
Module
ngi_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:ngi00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    103741502 (Plcb2)
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    103741502 (Plcb2)
   04310 Wnt signaling pathway
    103741502 (Plcb2)
   04371 Apelin signaling pathway
    103741502 (Plcb2)
   04020 Calcium signaling pathway
    103741502 (Plcb2)
   04070 Phosphatidylinositol signaling system
    103741502 (Plcb2)
   04072 Phospholipase D signaling pathway
    103741502 (Plcb2)
   04071 Sphingolipid signaling pathway
    103741502 (Plcb2)
   04022 cGMP-PKG signaling pathway
    103741502 (Plcb2)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    103741502 (Plcb2)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    103741502 (Plcb2)
   04613 Neutrophil extracellular trap formation
    103741502 (Plcb2)
   04621 NOD-like receptor signaling pathway
    103741502 (Plcb2)
   04062 Chemokine signaling pathway
    103741502 (Plcb2)
  09152 Endocrine system
   04911 Insulin secretion
    103741502 (Plcb2)
   04922 Glucagon signaling pathway
    103741502 (Plcb2)
   04929 GnRH secretion
    103741502 (Plcb2)
   04912 GnRH signaling pathway
    103741502 (Plcb2)
   04915 Estrogen signaling pathway
    103741502 (Plcb2)
   04921 Oxytocin signaling pathway
    103741502 (Plcb2)
   04926 Relaxin signaling pathway
    103741502 (Plcb2)
   04935 Growth hormone synthesis, secretion and action
    103741502 (Plcb2)
   04918 Thyroid hormone synthesis
    103741502 (Plcb2)
   04919 Thyroid hormone signaling pathway
    103741502 (Plcb2)
   04928 Parathyroid hormone synthesis, secretion and action
    103741502 (Plcb2)
   04916 Melanogenesis
    103741502 (Plcb2)
   04924 Renin secretion
    103741502 (Plcb2)
   04925 Aldosterone synthesis and secretion
    103741502 (Plcb2)
   04927 Cortisol synthesis and secretion
    103741502 (Plcb2)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    103741502 (Plcb2)
   04270 Vascular smooth muscle contraction
    103741502 (Plcb2)
  09154 Digestive system
   04970 Salivary secretion
    103741502 (Plcb2)
   04971 Gastric acid secretion
    103741502 (Plcb2)
   04972 Pancreatic secretion
    103741502 (Plcb2)
   04973 Carbohydrate digestion and absorption
    103741502 (Plcb2)
  09155 Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    103741502 (Plcb2)
  09156 Nervous system
   04724 Glutamatergic synapse
    103741502 (Plcb2)
   04725 Cholinergic synapse
    103741502 (Plcb2)
   04728 Dopaminergic synapse
    103741502 (Plcb2)
   04726 Serotonergic synapse
    103741502 (Plcb2)
   04720 Long-term potentiation
    103741502 (Plcb2)
   04730 Long-term depression
    103741502 (Plcb2)
   04723 Retrograde endocannabinoid signaling
    103741502 (Plcb2)
  09157 Sensory system
   04742 Taste transduction
    103741502 (Plcb2)
   04750 Inflammatory mediator regulation of TRP channels
    103741502 (Plcb2)
  09159 Environmental adaptation
   04713 Circadian entrainment
    103741502 (Plcb2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    103741502 (Plcb2)
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    103741502 (Plcb2)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    103741502 (Plcb2)
   05142 Chagas disease
    103741502 (Plcb2)
   05143 African trypanosomiasis
    103741502 (Plcb2)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    103741502 (Plcb2)
   05016 Huntington disease
    103741502 (Plcb2)
   05017 Spinocerebellar ataxia
    103741502 (Plcb2)
   05022 Pathways of neurodegeneration - multiple diseases
    103741502 (Plcb2)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    103741502 (Plcb2)
   05415 Diabetic cardiomyopathy
    103741502 (Plcb2)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    103741502 (Plcb2)
   04934 Cushing syndrome
    103741502 (Plcb2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:ngi04131]
    103741502 (Plcb2)
Enzymes [BR:ngi01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     103741502 (Plcb2)
Membrane trafficking [BR:ngi04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    103741502 (Plcb2)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    103741502 (Plcb2)
SSDB
Motif
Pfam: PLC-beta_C PI-PLC-X PH_14 PI-PLC-Y EF-hand_like C2 DUF1154
Other DBs
NCBI-GeneID: 103741502
NCBI-ProteinID: XP_008840540
Position
Un
AA seq 1181 aa
MSLLNPVLLPPKVKEYLSQGERFIKWDDETSIASPVILRVDPKGYYLYWTYQSKEMEFLD
ITNIRDTRFGKFAKMPKSQKLREVFNMDFPDDHFLLKALTVVSGPDMVDLTFHNFVSYKE
NVGKDWAEDVLALAKHPMTVNASRSTFLDKILVKLKMQRNPEGKIPVKNFFQMFPADRKR
VEAALSACHLAKGKNDAINPEDFPESVYKSFLMSLCPRPEIDEIFTSYHAKAKPYMTKEH
LTKFINQKQRDSRLNSLLFPPARPEQVQGLIDKYEPSGINVQRGQLSPEGMVWFLCGPEN
SVLSQNALLLHHDMTQPLNHYFINSSHNTYLTAGQFSGLSSAEMYRQVLLSGCRCVELDC
WKGKPPDEEPIITHGFTMTTDILFKEAIEAIAESAFKTSPYPVILSFENHVDSPRQQAKM
AEYCRTMFGETLLTEPLEKFPLKAGIPLPSPEDLRGKILIKNKKNQFSGPEAPSKKPGGE
AEGSCSPNASLGEDTVWAAEDRAEVEEEEVEEEEEEESGSLDEEEMKKMQSDEGTAGLEV
TAYEEMSSLVNYIQPTKFISFEFSAQKNRSYVISSFTELKASDLLSKASVQFVDYNKRQM
SRVYPKGTRMDSSNYMPQMFWNVGCQMVALNFQTMDLPMQQNMALFEFNGQSGYLLKHEF
MRRLDKQFNPFSVDRIDVVVATTLSITVISGQFLSERSVRTYVEVELFGLPGDPKRRYRT
KLSPTTNSINPVWKEEPFVFEKILMPELASLRVAVMEEGNKFLGHRIIPINALNSGYHHL
CLRSESNIPLTMPALFVFLEMKDYIPDTWADLTVALANPIKYFSAHDKKSVKLKEATGSL
LEKPFPLGSPATSQANGSSVPAGNGSAAPGTKAKEEARKEVAEPQTASLEELREMKGVVK
LQRRHEKELRELERRGARRREELLQRGAAQLAELGPPGTGCKLRPGKGSRKKRTLPCEEP
TAAAMGEFPEGTDSRLRELKDRLEQELQQHWEEQHRSILKRKEQHVAEQTAKMMEVAREK
QSAELKTFKETSEIDTKEMKKKLEAKRLERIQAMTKVTTDKVAQERLKREINNSHIQEVV
QAVKQMTETLERHQEKLEEKQAACLKQIREMEKQFQQEALAEYEARMKGLETEVKESVKA
CFRTCFPSEVQDKSDRTCDTSRELCWQDPLTDKADTQESRL
NT seq 3546 nt   +upstreamnt  +downstreamnt
atgtctctgctcaaccctgtcttgctgccccctaaggtgaaggagtatctgagccaaggc
gagcgcttcatcaagtgggatgatgaaacttcaatagcctccccagtcatccttcgtgtg
gatcccaagggatattacctatactggacatatcagagtaaggagatggagtttctggat
atcactaacatccgagacacccgctttggcaagtttgccaagatgcccaagagccagaaa
ctccgtgaggtcttcaacatggattttccagatgaccactttctgctgaaggcactcacg
gttgtgtccggccctgacatggtggaccttaccttccacaactttgtctcttacaaggaa
aacgtgggcaaggattgggctgaggatgtactggccctggccaagcacccgatgacagtc
aatgcttcccgcagcactttcctagacaagatcctggtgaagctcaagatgcagcgtaat
cctgaagggaagattcctgtgaagaattttttccagatgtttcctgctgaccgcaaacgt
gtagaagctgccctcagtgcttgtcaccttgcaaaaggcaagaatgatgctatcaatcct
gaggacttcccagaatccgtatacaagagcttcctaatgagcctctgtcctcggccagaa
atcgatgagatcttcacttcttaccatgctaaagccaaaccatacatgaccaaggaacac
ctgaccaaattcatcaatcagaagcagcgggactctcgactcaactccttgctgttccca
ccagcccgacctgagcaggtgcagggccttatcgacaagtatgagcccagcggcatcaat
gtacagaggggtcaattgtcacccgagggcatggtctggtttctctgcggaccagagaac
agtgtgctgtcccagaatgcactgttgcttcaccatgacatgacacagccacttaatcac
tatttcattaactcctcacacaacacctacttgacagctggccagttttcaggtctttct
tccgcggagatgtaccgccaggtactgctgtctggctgccgttgtgtggaactagactgt
tggaagggaaagcccccagatgaggagcccattattacccacggtttcaccatgaccaca
gacatcttattcaaggaagcaatcgaagccattgcagaaagtgcctttaagacctccccc
tatcctgtcatcttgtcatttgaaaaccatgtggactcaccccgccaacaggctaagatg
gctgaatactgccggaccatgtttggagagaccctgcttacagagcccctggaaaagttt
cctctgaaagctggcatccctctgcccagccctgaggacctccggggcaagatcctcatc
aagaataagaagaaccagttttctggtccagaagctcccagcaagaagcctggtggggag
gctgagggtagctgctcgcccaatgcctccttgggggaggacacagtgtgggctgctgag
gacagggctgaggtagaggaggaggaggtggaagaagaggaagaagaggagtcaggaagc
ctggatgaagaagagatgaagaagatgcagtcggatgagggcacagcaggcctggaggtg
actgcttatgaggaaatgtccagccttgtcaattatatccagcctaccaagttcatctcc
ttcgagttctctgcacagaagaaccgaagttatgtcatctcctccttcacggagctcaag
gcctctgacctgctctccaaagcctcggtgcagtttgtggactacaacaagcgccagatg
agtcgtgtgtaccccaagggcacacgtatggactcctccaactacatgccccagatgttc
tggaatgttggatgccagatggttgctctcaacttccagacaatggacctgcctatgcag
cagaacatggccctgttcgagttcaatgggcagagtggctacctcctcaagcatgagttc
atgcgccggctggacaaacagttcaaccctttctcagtggaccgcatcgatgtggtggta
gccaccaccctttccattacggtgatctctgggcagttcctgtctgaacgcagtgtacgc
acctatgtggaagtggaactgtttggtctcccaggggaccccaagaggcgttatcgcacc
aaactgtcacctacaactaactccatcaatcctgtctggaaggaggagccctttgtcttt
gagaagatcttgatgcctgagctagcctccctcagggtggctgtgatggaggaaggcaac
aaatttcttggacaccgaatcatccccattaatgctctaaattctggataccaccaccta
tgcctgcgtagtgagagcaacatacccctcactatgcctgcactcttcgtcttcctggag
atgaaggactatatacctgacacctgggcagatctcactgtggctctcgccaaccccatc
aaatacttcagtgctcatgataagaaatctgtgaagctcaaggaggccacaggaagtctg
cttgagaagcccttcccattggggagtcctgctaccagccaggccaatgggtcatctgtc
ccagcaggcaacgggtcagcagcacctggaaccaaagccaaggaggaagcccggaaagaa
gtggcagagccacagaccgccagtctggaggagctgcgggagatgaagggggtggtgaag
ctgcagaggcggcatgagaaggagcttcgggagctggagcggcggggagcccggcgccgg
gaggaactgctgcagcgaggtgcggcacagctggccgagctcgggccgccaggcacgggc
tgcaagcttcgcccaggcaagggctcccgcaagaagagaaccttgccctgcgaggagccc
actgcagctgcaatgggcgagttccccgaggggacggactcacggctgcgggagttgaag
gacaggctggaacaggagttacagcagcactgggaggagcagcaccggagtattctcaag
cgcaaggagcagcatgtagccgagcaaaccgccaagatgatggaggtagccagagagaaa
cagtctgcagagctcaagaccttcaaggagacctcagaaattgacaccaaagaaatgaag
aaaaaactggaggctaagaggttggagcggattcaggccatgaccaaagtcaccacagac
aaggtggcccaggaaaggctgaagagagagattaacaactcccacattcaggaagtggtg
caggctgtcaagcagatgacagagacactggaacgacaccaggaaaagctggaagagaag
caggcagcctgcctgaagcagatccgagagatggaaaagcagttccagcaggaggctctg
gctgagtatgaagccaggatgaagggcctagagactgaggtgaaggagtcggtgaaggcc
tgtttcaggacctgcttcccttctgaggtacaggacaagtctgacaggacctgtgatacc
tccagagagttgtgctggcaggatccactcacagacaaggcagacacccaggagagccgc
ctctga

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (61)   
   KEGG PATHWAY (60)   
   KEGG MODULE (1)   
Chemical substance (8)   
   KEGG COMPOUND (8)   
Chemical reaction (4)   
   KEGG ENZYME (1)   
   KEGG REACTION (3)   
Genome (1)   
   KEGG GENOME (1)   
Gene (16)   
   KEGG ORTHOLOGY (1)   
   RefGene (12)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   OC (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   RefSeq(nuc) (1)   
Protein domain (7)   
   Pfam (7)   
All databases (102)   

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