KEGG   Nannospalax galili (Upper Galilee mountains blind mole rat): 103745927
Entry
103745927         CDS       T03372                                 
Symbol
Lck
Name
(RefSeq) LCK proto-oncogene, Src family tyrosine kinase
  KO
K05856  lymphocyte cell-specific protein tyrosine kinase [EC:2.7.10.2]
Organism
ngi  Nannospalax galili (Upper Galilee mountains blind mole rat)
Pathway
ngi04064  NF-kappa B signaling pathway
ngi04380  Osteoclast differentiation
ngi04650  Natural killer cell mediated cytotoxicity
ngi04658  Th1 and Th2 cell differentiation
ngi04659  Th17 cell differentiation
ngi04660  T cell receptor signaling pathway
ngi05135  Yersinia infection
ngi05166  Human T-cell leukemia virus 1 infection
ngi05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
ngi05340  Primary immunodeficiency
Brite
KEGG Orthology (KO) [BR:ngi00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04064 NF-kappa B signaling pathway
    103745927 (Lck)
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    103745927 (Lck)
   04660 T cell receptor signaling pathway
    103745927 (Lck)
   04658 Th1 and Th2 cell differentiation
    103745927 (Lck)
   04659 Th17 cell differentiation
    103745927 (Lck)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    103745927 (Lck)
 09160 Human Diseases
  09161 Cancer: overview
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    103745927 (Lck)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    103745927 (Lck)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    103745927 (Lck)
  09163 Immune disease
   05340 Primary immunodeficiency
    103745927 (Lck)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:ngi01001]
    103745927 (Lck)
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:ngi03036]
    103745927 (Lck)
Enzymes [BR:ngi01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.2  non-specific protein-tyrosine kinase
     103745927 (Lck)
Protein kinases [BR:ngi01001]
 Non-receptor tyrosine kinases
  SRC family
   103745927 (Lck)
Chromosome and associated proteins [BR:ngi03036]
 Eukaryotic type
  Centrosome formation proteins
   Kinases and associated factors
    103745927 (Lck)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase SH2 SH3_1 SH3_2 SH3_9 ABC1 Haspin_kinase SH3_16 SH3_3
Other DBs
NCBI-GeneID: 103745927
NCBI-ProteinID: XP_008846195
UniProt: A0A8C6QM88
Position
Un
AA seq 509 aa
MGCSCSSNPEDDWMENIDVCENCHYPIVPLDGKTTLPIRNGSEVRDPLVTYEGCNPPASP
LQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKAN
SLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKH
YKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEV
PRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRL
VRLYAVVTQEPIYIITEYMENGSLVDFLKTPLGIKLSINKLLDMAAQIAEGMAFIEERNY
IHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIK
SDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVQPDNCPEELYHLMMLCWKER
PEDRPTFDYLRSVLEDFFTATEGQYQPQP
NT seq 1530 nt   +upstreamnt  +downstreamnt
atgggctgtagctgcagctcaaaccctgaagacgactggatggaaaacatcgatgtgtgc
gagaactgccactatcccatagtcccactggatggcaagaccacgctgcccatccggaat
ggctctgaagtccgggacccactggtcacctatgagggctgcaacccaccagcctctcca
ttgcaagacaacttggttattgccctgcacagctatgaaccttcccatgatggagacctg
ggttttgagaagggtgaacagctccgtattctggaacagagcggtgaatggtggaaggct
cagtccctgaccaccggccaggaaggcttcatccccttcaacttcgtggccaaagcaaac
agcctggagcctgagccttggttcttcaagaatctgagccgtaaggacgcagaacggcag
cttttggcgccagggaacacacacggatccttcctgatccgggagagcgagagcactgct
ggatccttttcactgtctgtcagggacttcgaccagaaccagggcgaggtggtgaaacat
tacaagatccgtaacctagacaacggtggcttctacatctcccctcgtataacttttccc
ggcctacatgaactggtccgccattataccaatgcctctgatgggctgtgcacgcgattg
agccgtccttgccagacccagaaacctcagaagccatggtgggaggatgaatgggaggtg
cccagggagacgctgaagttggttgagaggctgggggccggacagtttggggaagtctgg
atggggtactacaacgggcatacgaaggtggccgtaaagagcctgaagcaagggagcatg
tcccctgatgccttcctggctgaagctaacctcatgaagcagctgcagcaccagcggttg
gtccggctttatgcagttgtcacccaggagcccatctatatcatcaccgaatacatggag
aacgggagcctagtagattttctcaagacccctttaggtatcaagttgtccatcaacaaa
ctcttggacatggcagcccagattgcagagggcatggcatttattgaggaacggaactac
atccaccgtgatcttcgggctgccaacatcctggtgtctgacacattgagctgcaagatt
gcagactttggcctcgcacgcctcattgaagacaatgagtacacagccagagagggagcc
aaatttcccattaaatggacagcaccagaagccattaactatgggaccttcaccatcaag
tcagatgtgtggtcttttgggatcctgctgacagagattgtcacccatggccgcattcct
tatccagggatgaccaatcctgaagtgattcagaacctggagcgaggctaccgcatggtg
caacctgacaactgtccagaagagctgtatcaccttatgatgttgtgctggaaggagcgc
ccagaggaccggcccacctttgactaccttcgcagtgtgctggaggacttcttcacggcc
acagagggccagtaccagccccagccatga

  All links  
Ontology (4)   
   KEGG BRITE (4)   
Pathway (10)   
   KEGG PATHWAY (10)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (7)   
   KEGG ORTHOLOGY (1)   
   RefGene (3)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   OC (1)   
Protein sequence (2)   
   UniProt (1)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   RefSeq(nuc) (1)   
Protein domain (10)   
   Pfam (10)   
All databases (36)   

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