KEGG   Ornithorhynchus anatinus (platypus): 100088528
Entry
100088528         CDS       T01045                                 
Symbol
DOT1L
Name
(RefSeq) histone-lysine N-methyltransferase, H3 lysine-79 specific isoform X1
  KO
K11427  [histone H3]-lysine79 N-trimethyltransferase [EC:2.1.1.360]
Organism
oaa  Ornithorhynchus anatinus (platypus)
Pathway
oaa00310  Lysine degradation
oaa01100  Metabolic pathways
oaa05202  Transcriptional misregulation in cancer
Brite
KEGG Orthology (KO) [BR:oaa00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00310 Lysine degradation
    100088528 (DOT1L)
 09160 Human Diseases
  09161 Cancer: overview
   05202 Transcriptional misregulation in cancer
    100088528 (DOT1L)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:oaa03036]
    100088528 (DOT1L)
Enzymes [BR:oaa01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.360  [histone H3]-lysine79 N-trimethyltransferase
     100088528 (DOT1L)
Chromosome and associated proteins [BR:oaa03036]
 Eukaryotic type
  Histone modification proteins
   HMTs (histone methyltransferases)
    HKMTs (histone lysine methyltransferases)
     100088528 (DOT1L)
   HMT complexes
    Dot1-containing complex
     100088528 (DOT1L)
SSDB
Motif
Pfam: DOT1
Other DBs
NCBI-GeneID: 100088528
NCBI-ProteinID: XP_028913200
Ensembl: ENSOANG00000010015
Position
Unknown
AA seq 1559 aa
MGEKLELRLKSPVGAEPAVYPWPLPVYDKHHDAAHEIIETIRWVCEEIPDLKLAMENYVL
IDYDTKSFESMQRLCDKYNRAIDSIHQLWKGTTQPMKLNTRPSNGLLRHILQQVYNHSVT
DPEKLNNYEPFSPEVYGETSFDLVAQMIDEIKMTEDDLFVDLGSGVGQVVLQVAAATNCK
HHYGVEKADIPAKYAETMDREFRKWMKWYGKKHAEYTLERGDFLSEEWRERIANTSVIFV
NNFAFGPEVDHQLKERFANMKEGGRIVSSKPFAPLNFRINSRNLSDIGTIMRVVELSPLK
GSVSWTGKPVSYYLHTIDRTILENYFSSLKNPKLREEQEAARRRQQRENKSNTTTPTKVQ
ENKVAVLLDCHMDSGAEEDKTGVATVKKPSPSKARKKKLSKKGRKMAGRKRGRPKKMNTA
NTERKPKKNQTALELLHAQTVSQTASSSPQDAYKSPHSPYYQLPPKVQRHSSNQLLVTPT
PPALQKLLDSFKIQYMQFMAYMKTPQYKANLQQLLEQEKEKNAQLLGTAQQLFIHCQAQK
EEIKRLFQQKLDELGVKALTYNDLIQAQKEISAHNQQLKEQTKQLEKENSELRNQSLQLL
KARCEELKLDWSTLSLENLLKEKQALKNQISEKQKHCLELQISIVELEKSQRQQELLQLK
SYMPADETPSVHLRHKSHLNRELEPEHSRFQLELECAKFSLPHINGMSPELSMNGHAAPY
EIPSTLSRSSSKQNTPQYLTSHLDQEIVPCTPNHNSRQKVDRVASLSIPDYTRFSPAKIA
LRRHLNQDHAATGKAPASDLHQRAEHAKENGLSYQSPGISNGIKLSPQHVRPSSPSALQI
AAGEKNTEKVLKERAYASNGETITSLPISIPLSTVQPNKLPVSIPLSSVVLPSRVEKVRS
TPSPVHQTRDSTSTLEKQFGANSYNGLSSATGTKPFASATSGFSYSGSVAVGGTVSSSPA
QLNHVVEQTALDDPSNSGSLFNAVGSRSSTPQHPSLLMMQCRNSGPNSPAHQHPVSPRLP
GAAQGLPGALQHADPQKMFTEGHMGDLQSDWGFSDPESEAKRRIIFTISTNAGNLKQSPS
NKHSPLTASIRTDCGPAYMQDGKKRGRRKRSSSGHPSGLSPKRKPLPSVAGLFTPSSGSP
LNINSMVNNINQPLEITAISSPENSLKNSPVPYQDNDQPPVLKKEKPLIQTNGIYYSPLT
SDEEQGSEDERNSTRIERKIATISLESKSPPKSMENAGGSGSSGRKPGPTHESTNSSKWK
STFSPISDLHLAKTADSPGQAAPPLFAFRPPSEDAGPADGKLSVHPRKNLAGGSAGAGAL
SPNGFAYNGGLSADLSLHSFPDGASLSHKASEVTGLHSPLGFPSQRSRDVSVSETNPFLN
KRQLDGLGGLKGDEFGRAGGKSKEMSELGVHPSEKGPLQHSGKVGKGRDRDLEFKNGHNL
FIAAAAAPPGGLLNGRSLPTAGPSSGNSVSAVQTHHPFLNAVTAGSQFPLGPGTLPANLS
SVASSSVLQSLFNSVPTAASLVHVSSAATRLTNSHAMGSFSSGVTGGTVGGRQNVASQL
NT seq 4680 nt   +upstreamnt  +downstreamnt
atgggggagaagctggaactgaggctgaagtcgccggtgggagcggagcctgccgtatac
ccctggcccttgccggtctacgataaacaccacgatgctgctcatgagatcattgagacc
attcgatgggtctgtgaagaaatcccagatctcaaacttgccatggaaaattatgttctg
attgactatgataccaaaagctttgaaagcatgcagagactctgtgacaagtacaaccga
gccattgatagcatccatcagttgtggaaaggaaccacccagcccatgaaactgaacact
cgtccatccaatggacttctccggcatattttgcagcaagtgtataaccactcagtgacg
gacccagagaaactcaacaactatgagcctttttccccagaagtgtatggagagacttcg
tttgacttagtggcccagatgattgatgagattaaaatgacagaagatgatttgtttgtg
gacttgggcagtggagtgggtcaggtggtgcttcaggtggcggcagccaccaactgcaag
catcattatggtgtggagaaagctgatattccagccaagtatgccgagacaatggacaga
gagttcagaaagtggatgaaatggtatgggaaaaagcatgcagaatacacactggaaaga
ggtgacttcctctcggaagagtggcgagaacgaatagcaaatacaagtgttatttttgtg
aataattttgcctttggtcctgaggtggatcaccaactgaaagaacgatttgcaaacatg
aaggaaggtggcagaatcgtatcctcaaaaccttttgcacctctaaactttagaataaac
agtaggaacttgagtgatattggcactataatgagagttgtggagttatcaccactgaaa
gggtcggtttcatggactgggaaaccagtctcttactacttgcataccattgatcgaaca
atacttgaaaactatttttctagtctcaaaaatccaaagctcagggaggaacaagaggca
gctagacgccgacagcaaagagaaaacaagagtaatacgacaactccaacaaaggtccaa
gaaaacaaggtagctgttctcttggattgtcacatggattctggtgctgaagaagataaa
actggggtagcgactgtaaaaaagccatctccctccaaagcacgcaagaaaaagttaagc
aagaaaggaaggaaaatggcgggcagaaagcgtgggcgccccaagaaaatgaacactgca
aacactgagcgcaagcccaagaagaaccaaaccgcactggagctcctacatgctcaaact
gtgtcccagacagcatcatcctctcctcaggatgcatacaagtcacctcatagcccatat
taccaactacctcctaaagtgcaacggcattcatctaatcagctgttggtgactcccacc
ccccctgcactacagaagctgctagactcctttaagattcagtacatgcaatttatggca
tacatgaaaactcctcaatataaggcaaacctacagcagttactggagcaagaaaaggaa
aaaaatgcccagctgctgggcaccgcacaacaactgttcatccattgccaggcccagaaa
gaggaaatcaagcgactatttcagcagaaactcgatgagttgggagttaaggcactgact
tacaatgacctgattcaagctcagaaagagatctccgctcataaccagcagttaaaggaa
caaaccaaacagctagagaaagagaacagtgaactcaggaaccagagcttacagctgctt
aaggctcgatgcgaagagctgaagctggattggtccaccctgtcgctggagaatttactg
aaggaaaagcaggccctgaagaatcaaatttcagaaaagcagaagcattgtttggagttg
cagatcagcatcgtggagctggagaagagtcaaaggcagcaggagctgttgcagctcaag
tcctacatgccagctgatgagacaccgtcggttcatctgcgccacaaaagccatttaaac
cgggagctcgaacccgagcacagccgattccaacttgagcttgagtgcgccaagttctct
ctgccccacatcaacggcatgagccccgaactgtccatgaatggccatgcggctccctat
gaaattcccagtacgttgagccggtcctcttccaagcagaacacccctcagtacctgacc
tcccacctggaccaagaaatcgtgccctgcactcctaaccacaacagcaggcagaaggtg
gaccgagtggccagcttatccatccccgactacacccggttttctccagccaagatagcc
ctacggagacacttgaatcaggatcatgcagccactgggaaagccccagctagtgacctg
caccagagagctgagcatgccaaagagaatggcctttcatatcagagccccgggatttca
aacggcataaaactgagtcctcagcacgttcggccttcttctccttctgctttacagatt
gcagcgggagagaagaacactgagaaggttttgaaagaaagagcctatgccagcaatgga
gaaacgatcaccagcttacccatcagtattcctctcagcacagtgcagcccaataaactc
cctgttagtatcccactgtccagtgtagtcctgcccagccgggttgagaaggtgagaagc
acacctagtccagttcatcagactcgagactctacttcaacacttgaaaaacagtttggt
gctaattcctataatggtctaagcagtgctactggaaccaagccctttgcttcggctacc
tcaggtttttcttattctggctcggtggcagtcgggggaactgtttccagcagcccggcc
cagcttaaccacgtcgttgagcagactgctctggatgacccgtccaattcggggagtctg
ttcaacgcagtaggctcccggagctccaccccacaacatccttctttgctcatgatgcag
tgccggaattctggtccgaactcccccgcccaccagcacccggtgagcccccggctcccc
ggggccgcccaggggctgcctggggcgttgcagcatgcagatcctcagaagatgttcact
gagggccacatgggagacctgcagtctgattggggcttttctgatcccgagagtgaagcc
aagagaagaattatctttaccatctctacaaatgcaggaaacctaaaacagtctccttcc
aacaagcacagtcccctaacggcaagcatccgaacggactgtgggccagcctatatgcag
gacggcaagaagagagggaggaggaagcggtcttccagcgggcaccccagcgggctgtct
cccaaacgcaaacccttaccgtccgtggcgggactctttactccgtcgtcaggctcaccc
ctcaacatcaactctatggtcaataacattaatcagcctttagagatcacagccatttcc
tccccggaaaactccctgaagaattctcctgttccctaccaggacaacgaccaaccgccg
gtgctgaaaaaggagaagccgctcatccagaccaatgggatttactattccccgctcacg
tctgatgaagaacagggatccgaagatgagcgcaacagcaccagaattgaaagaaaaatt
gccaccatctctttggaaagcaaatccccaccaaaatcaatggaaaatgcagggggcagc
ggttcgtcaggaaggaaaccgggaccgacccacgagagcacgaatagcagcaagtggaag
tccaccttctcacccatctccgatctccacctggccaagacggccgacagccccgggcag
gccgcaccacctctgttcgccttcaggccgccctcggaggacgctgggcctgccgacggc
aagctctcggtgcacccccggaaaaacttggccgggggctcggcgggggctggtgcgctc
agcccgaatggatttgcctacaatgggggcctgtcagccgatctgagtttacacagcttt
cctgatggtgcttctctctctcataaggctagcgaggtgacgggcttacattcccctctg
ggttttccatcccagcggagcagagacgtcagtgtctccgagacaaacccctttctgaac
aagcggcagctggatggcctggggggcttgaaaggggacgaatttggaagggcagggggc
aaaagcaaagagatgagtgagttgggggtgcatccatctgaaaaagggcccctgcagcac
agtggcaaggttgggaaaggacgggaccgtgacctggagtttaaaaatggccacaacctt
ttcatcgccgccgccgctgcccctcctgggggccttctcaatggcagaagccttcccacg
gctggcccctcttctggcaactcagtatctgccgtgcaaacgcaccatcctttcttaaac
gctgtcaccgctggatcccagttccccctgggccccgggaccctgccggccaacctcagt
tctgtggccagctcatcggtcttgcagtccttatttaattcagtgcccacagctgccagt
ttggtccacgtgtcatcggctgcaaccagactgacaaattctcatgctatgggaagcttc
tcttccggggtgacgggtggaacagttggaggtaggcagaacgtggcttctcagctctga

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (3)   
   KEGG PATHWAY (3)   
Chemical substance (6)   
   KEGG COMPOUND (6)   
Chemical reaction (4)   
   KEGG ENZYME (1)   
   KEGG REACTION (3)   
Genome (1)   
   KEGG GENOME (1)   
Gene (66)   
   KEGG ORTHOLOGY (1)   
   RefGene (61)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (5)   
   RefSeq(pep) (5)   
DNA sequence (5)   
   RefSeq(nuc) (5)   
Protein domain (1)   
   Pfam (1)   
All databases (94)   

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