KEGG   Oryctolagus cuniculus (rabbit): 100009487
Entry
100009487         CDS       T03373                                 

Gene name
PPP3CB
Definition
(RefSeq) protein phosphatase 3 catalytic subunit beta
  KO
K04348  serine/threonine-protein phosphatase 2B catalytic subunit [EC:3.1.3.16]
Organism
ocu  Oryctolagus cuniculus (rabbit)
Pathway
ocu04010  MAPK signaling pathway
ocu04020  Calcium signaling pathway
ocu04022  cGMP-PKG signaling pathway
ocu04114  Oocyte meiosis
ocu04218  Cellular senescence
ocu04310  Wnt signaling pathway
ocu04360  Axon guidance
ocu04370  VEGF signaling pathway
ocu04380  Osteoclast differentiation
ocu04625  C-type lectin receptor signaling pathway
ocu04650  Natural killer cell mediated cytotoxicity
ocu04658  Th1 and Th2 cell differentiation
ocu04659  Th17 cell differentiation
ocu04660  T cell receptor signaling pathway
ocu04662  B cell receptor signaling pathway
ocu04720  Long-term potentiation
ocu04724  Glutamatergic synapse
ocu04728  Dopaminergic synapse
ocu04921  Oxytocin signaling pathway
ocu04922  Glucagon signaling pathway
ocu04924  Renin secretion
ocu05010  Alzheimer disease
ocu05014  Amyotrophic lateral sclerosis (ALS)
ocu05031  Amphetamine addiction
ocu05152  Tuberculosis
ocu05163  Human cytomegalovirus infection
ocu05166  Human T-cell leukemia virus 1 infection
ocu05167  Kaposi sarcoma-associated herpesvirus infection
ocu05170  Human immunodeficiency virus 1 infection
ocu05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:ocu00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    100009487 (PPP3CB)
   04310 Wnt signaling pathway
    100009487 (PPP3CB)
   04370 VEGF signaling pathway
    100009487 (PPP3CB)
   04020 Calcium signaling pathway
    100009487 (PPP3CB)
   04022 cGMP-PKG signaling pathway
    100009487 (PPP3CB)
 09140 Cellular Processes
  09143 Cell growth and death
   04114 Oocyte meiosis
    100009487 (PPP3CB)
   04218 Cellular senescence
    100009487 (PPP3CB)
 09150 Organismal Systems
  09151 Immune system
   04625 C-type lectin receptor signaling pathway
    100009487 (PPP3CB)
   04650 Natural killer cell mediated cytotoxicity
    100009487 (PPP3CB)
   04660 T cell receptor signaling pathway
    100009487 (PPP3CB)
   04658 Th1 and Th2 cell differentiation
    100009487 (PPP3CB)
   04659 Th17 cell differentiation
    100009487 (PPP3CB)
   04662 B cell receptor signaling pathway
    100009487 (PPP3CB)
  09152 Endocrine system
   04922 Glucagon signaling pathway
    100009487 (PPP3CB)
   04921 Oxytocin signaling pathway
    100009487 (PPP3CB)
   04924 Renin secretion
    100009487 (PPP3CB)
  09156 Nervous system
   04724 Glutamatergic synapse
    100009487 (PPP3CB)
   04728 Dopaminergic synapse
    100009487 (PPP3CB)
   04720 Long-term potentiation
    100009487 (PPP3CB)
  09158 Development and regeneration
   04360 Axon guidance
    100009487 (PPP3CB)
   04380 Osteoclast differentiation
    100009487 (PPP3CB)
 09160 Human Diseases
  09161 Cancer: overview
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    100009487 (PPP3CB)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    100009487 (PPP3CB)
   05014 Amyotrophic lateral sclerosis (ALS)
    100009487 (PPP3CB)
  09165 Substance dependence
   05031 Amphetamine addiction
    100009487 (PPP3CB)
  09171 Infectious disease: bacterial
   05152 Tuberculosis
    100009487 (PPP3CB)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    100009487 (PPP3CB)
   05170 Human immunodeficiency virus 1 infection
    100009487 (PPP3CB)
   05163 Human cytomegalovirus infection
    100009487 (PPP3CB)
   05167 Kaposi sarcoma-associated herpesvirus infection
    100009487 (PPP3CB)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins [BR:ocu01009]
    100009487 (PPP3CB)
Enzymes [BR:ocu01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.16  protein-serine/threonine phosphatase
     100009487 (PPP3CB)
Protein phosphatases and associated proteins [BR:ocu01009]
 Protein serine/threonine phosphatases
  Phosphoprotein phosphatases (PPPs)
   Calcineurin (PPP3/ PP2B)
    Catalytic subunits
     100009487 (PPP3CB)
SSDB
Motif
Pfam: Metallophos DUF5378
Other DBs
NCBI-GeneID: 100009487
NCBI-ProteinID: NP_001076196
Ensembl: ENSOCUG00000012543
UniProt: Q8HZM9
Position
18
AA seq 524 aa
MAAPEPARAAPPPPPPPPPPPGADRVVKAVPFPPTHRLTSEEVFDVDGIPRVDVLKNHLV
KEGRVDEEIALRIINEGAAILRREKTMIEVEAPITVCGDIHGQFFDLMKLFEVGGSPANT
RYLFLGDYVDRGYFSIECVLYLWVLKILYPSTLFLLRGNHECRHLTEYFTFKQECKIKYS
ERVYEACMEAFDSLPLAALLNQQFLCVHGGLSPEIHTLDDIRRLDRFKEPPAFGPMCDLL
WSDPSEDFGNEKSQEHFSHNTVRGCSYFYNYPAVCEFLQNNNLLSIIRAHEAQDAGYRMY
RKSQTTGFPSLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQFNCSPHPYWLPNFMDVFT
WSLPFVGEKVTEMLVNVLSICSDDELMTEGEDQFDGSAAARKEIIRNKIRAIGKMARVFS
VLREESESVLTLKGLTPTGMLPSGVLAGGRQTLQSATVEAIEAEKAIRGFSPPHRICSFE
EAKGLDRINERMPPRKDAVQQDGFNSLNTAHATENHGTGNHNAQ
NT seq 1575 nt   +upstreamnt  +downstreamnt
atggccgccccggagccggcgcgggccgcaccgcccccacccccgcccccgccgccccct
cccggggctgaccgcgtcgtcaaagctgtccctttccctccaacacatcgtttgacatct
gaagaagtatttgatgtggacgggatacccagggttgatgttttgaagaaccacttagta
aaagaaggtcgagtagatgaagaaattgcacttagaattatcaatgagggtgctgccatc
cttcggagagagaaaaccatgatagaagtagaagctccaattacagtgtgtggtgatatc
catggccaattttttgatctgatgaaactgtttgaagtaggaggatcacctgctaataca
cgatacctttttcttggtgattatgtggacagaggttactttagtatagagtgtgtctta
tatttatgggtcttgaagattctgtacccaagcacattatttcttctgagaggaaaccat
gaatgcagacaccttactgaatattttacctttaaacaggaatgtaaaattaaatattca
gaaagagtctatgaagcttgtatggaagcttttgatagcctgcctcttgctgcactttta
aaccaacagtttctctgtgttcatggtggactttcacccgaaatacacacactggatgat
attaggagattagatagattcaaagagccacctgcatttggaccaatgtgtgacttgcta
tggtccgatccttctgaagattttggaaatgaaaaatcacaggaacattttagtcacaat
acagttcgaggatgttcttatttttataactatccagcagtgtgtgaatttttgcaaaac
aataatttgttatcgattattagagctcatgaagctcaagatgcaggctatagaatgtac
agaaaaagtcaaactacagggttcccttcattaataacaattttttcggcccctaattac
ttagatgtctacaataataaagctgctgtattaaagtatgaaaataatgtgatgaatatt
cgacagtttaactgttctccacatccttactggttacccaattttatggatgtcttcaca
tggtctttaccatttgttggggaaaaagtgaccgaaatgttggtaaatgtcttgagtatt
tgctctgatgatgaactaatgactgaaggtgaagaccaatttgatggttcagctgcagcc
cggaaagaaatcataagaaacaaaattcgagcaattggcaagatggcaagagtcttctct
gttctcagggaggagagtgaaagtgtgctgacactcaagggcctgactcccacagggatg
ttgcctagtggagtgttggctggaggacggcagaccctacaaagtgccacagttgaggct
attgaggctgaaaaagcaatacgaggattctctccaccacatagaatctgcagttttgaa
gaggcaaagggtttggataggatcaatgagagaatgccaccccggaaagatgctgtacag
caagatggtttcaattctctgaacaccgcacatgccactgagaaccacgggactggcaac
cataatgcccagtga

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