KEGG   Oryctolagus cuniculus (rabbit): 100339981
Entry
100339981         CDS       T03373                                 
Name
(RefSeq) insulin receptor substrate 1
  KO
K16172  insulin receptor substrate 1
Organism
ocu  Oryctolagus cuniculus (rabbit)
Pathway
ocu04022  cGMP-PKG signaling pathway
ocu04068  FoxO signaling pathway
ocu04140  Autophagy - animal
ocu04150  mTOR signaling pathway
ocu04151  PI3K-Akt signaling pathway
ocu04152  AMPK signaling pathway
ocu04211  Longevity regulating pathway
ocu04213  Longevity regulating pathway - multiple species
ocu04722  Neurotrophin signaling pathway
ocu04910  Insulin signaling pathway
ocu04920  Adipocytokine signaling pathway
ocu04923  Regulation of lipolysis in adipocytes
ocu04930  Type II diabetes mellitus
ocu04931  Insulin resistance
ocu04932  Non-alcoholic fatty liver disease
ocu04935  Growth hormone synthesis, secretion and action
ocu04960  Aldosterone-regulated sodium reabsorption
ocu05010  Alzheimer disease
ocu05206  MicroRNAs in cancer
ocu05415  Diabetic cardiomyopathy
Brite
KEGG Orthology (KO) [BR:ocu00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04068 FoxO signaling pathway
    100339981
   04022 cGMP-PKG signaling pathway
    100339981
   04151 PI3K-Akt signaling pathway
    100339981
   04152 AMPK signaling pathway
    100339981
   04150 mTOR signaling pathway
    100339981
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    100339981
 09150 Organismal Systems
  09152 Endocrine system
   04910 Insulin signaling pathway
    100339981
   04923 Regulation of lipolysis in adipocytes
    100339981
   04920 Adipocytokine signaling pathway
    100339981
   04935 Growth hormone synthesis, secretion and action
    100339981
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    100339981
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    100339981
  09149 Aging
   04211 Longevity regulating pathway
    100339981
   04213 Longevity regulating pathway - multiple species
    100339981
 09160 Human Diseases
  09161 Cancer: overview
   05206 MicroRNAs in cancer
    100339981
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    100339981
  09166 Cardiovascular disease
   05415 Diabetic cardiomyopathy
    100339981
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    100339981
   04932 Non-alcoholic fatty liver disease
    100339981
   04931 Insulin resistance
    100339981
SSDB
Motif
Pfam: IRS PH PH_11
Other DBs
NCBI-GeneID: 100339981
NCBI-ProteinID: XP_002712555
Position
7:5126214..5184722
AA seq 1241 aa
MASPPETEGFSDVRKVGYLRKPKSMHKRFFVLRAASEAGGPARLEYYENEKKWRHKSSAP
KRSIPLESCFNINKRADSKNKHLVALYTRDEHFAIAADSEAEQDSWYQALLQLHNRAKGH
HDGASATGAGGAGGSCSGSSGLGEAGEDLSYGDMPPGPAFKEVWQVILKPKGLGQTKNLI
GIYRLCLTSKTISFVKLNSEAAAVVLQLMNIRRCGHSENFFFIEVGRSAVTGPGEFWMQV
DDSVVAQNMHETILEAMRAMSDEFRPRSKSQSSSNCSNPISVPLRRHHLNNPPPSQVGLT
RRSRTESITATSPASMVGGKPGSFRVRASSDGEGTMSRPASVDGSPVSPSTNRTHAHRHR
GSSRLHPPLNHSRSIPMPSSRCSPSATSPVSLSSSSTSGHGSTSDCLFPRRSSASVSGSP
SDGGFISSDEYGSSPCDFRSSFRSVTPDSLGHTPPARGEEELSNYICMGGKGASTLAAPN
GHYILARGGNGHRYIPGAGLGVSPALAAEDAASAADLENRFRKRTHSAGTSPTISHQKTP
SQSSVEYTEMMPAYPPGGGSGGRLPGYRHSAFVPTHSYPEEGLEMHPLERRGGHHRPDSS
TLHTDDGYMPMSPGVAPVPGSSRKGSGDYMPMSPKSVSAPQQIINPIRRHPQRVDPNGYM
MMSPSGSCSPDIGGGPSSSSGSSGVSAAPSGSSYGKLWTNGVGGHHSHALPHPKPPAESS
GGKLLPCTGEYMNMSPVGDSNTSSPSDCYYGPEDPQHKPVLSYYSLPRSFKHTQRPGELE
EGARHQHLRLSSSSGRLLYAATAEDSSSSTSSDSLGGGYCGARPEPGLPHPHHHVLQPHL
PRKVDTAAQTNSRLARPTRLSLGDPKASTLPRVREQQQQQQSLPHPPEPKSPGEYVNIEF
GSDQPGYLSGPVASHSSPSIRCPPQLQPAPREEETGTEEYMNMDLGPGRRATWQENTGAD
LGRVGPAPPGAASVCRPTRAVPSSRGDYMTMQMGCSRQSYVDTSPVAPVCYADMRAGIAA
EEASLPRATAAAPSSSSAASSSPTEPQGAAELATRSSLLGGPQGPGGMSAFTRVTLSPNR
NQSAKVIRADPQGCRRRHSSETFSSTPSATRAGNTVSFGGGASGGGSGGSGSEDVKRHSS
ASFENVWLRPGELVGAPKETAQVCGAAGGLENGLNYIDLDLVKDFKQRPQERPPQPQPPQ
PVPPHPHQPLGSGESSSTSRSSEDLSAYASISFQKQPEDRQ
NT seq 3726 nt   +upstreamnt  +downstreamnt
atggcgagccctccggagaccgaaggcttctcggacgtgcgcaaggtgggctacctgcgc
aaacccaagagcatgcacaagcgctttttcgtgctgcgggccgccagcgaggcggggggc
ccggcgcgcctcgagtactacgagaacgagaagaagtggcggcacaagtcgagcgccccc
aaacgctcgatccccctggagagctgcttcaacatcaacaagcgggctgactccaagaac
aagcacctggtggctctctacacccgggacgaacactttgccattgcggcagacagcgag
gccgagcaggacagctggtaccaggctctcctgcagctgcacaaccgcgccaagggccac
cacgatggggcctcggccaccggggcgggaggcgctgggggcagctgcagcggcagctct
ggcctgggcgaggctggagaggacttgagctacggggacatgcccccaggacccgccttc
aaggaggtctggcaggtgatcttgaaacccaaaggcctggggcagacaaagaatttgatc
ggcatctaccgcctgtgcctgaccagcaagaccatcagcttcgtgaagctgaactcggag
gccgcggccgtggtgctgcagctgatgaacatcaggcgctgcggccactccgagaacttc
ttcttcatcgaggtgggccgctccgccgtgacgggccccggcgagttctggatgcaggtg
gatgactccgtggtggcccagaacatgcacgagaccatcttggaggccatgcgggccatg
agcgacgagttccgccctcgcagcaagagccagtcctcctccaactgctccaaccccatc
agcgtccccctgcgccggcaccatctcaacaacccgccgcccagccaggtggggctgacg
cgccgctcgcgcaccgagagcatcaccgccacctccccggccagcatggtgggcgggaag
ccaggttccttccgggtccgcgcctccagcgacggcgaaggcaccatgtcgcgcccagcc
tcggtggacggcagcccggtgagccccagcaccaacaggacccacgcccaccggcatcgg
ggcagctcccggctgcacccgccgctcaaccacagccgctccatacccatgccttcttct
cgctgctcgccgtcggccaccagccccgtcagtttgtcgtccagcagcaccagtggccac
ggctccacctcggactgtctcttcccgcggcggtcgagcgcctctgtgtccggctccccc
agcgatggtggcttcatctcctccgacgagtatggctcgagtccttgcgactttcgaagt
tccttccgcagtgtcactcccgattccctgggccacaccccgccagcccgcggtgaggag
gagctcagtaactacatctgcatgggcggcaaaggggcctccaccctggccgcccccaac
ggtcactacattttggctcgcggaggcaatggccaccgctacatccccggggcgggcctg
ggcgtgagccccgccctggctgcggaggatgcagccagcgccgccgacctggaaaatcgc
ttccggaagcgaactcactcggcgggcacctcccctaccatttcgcaccagaagacccca
tcgcagtcctcggtggagtacacagagatgatgcctgcctacccaccgggaggtggcagt
ggaggccgactgcccggctacaggcactccgccttcgtgcccacccactcttaccccgag
gagggtctggagatgcaccccttggagcgccgcgggggccaccaccggccagactcctcc
actctccacactgacgatggctacatgcccatgtccccgggggtggccccggtgccaggg
agcagccgcaagggcagtggggactacatgcccatgagccccaagagtgtatctgcccct
caacagatcatcaaccccatcagacgccacccccagagagtggaccccaatggctacatg
atgatgtcccccagtggcagctgctcccctgacattggcggtgggcccagcagcagcagt
ggcagcagcggcgtcagcgccgccccttccgggagcagctacggcaagctgtggaccaat
ggggtagggggccaccactctcatgccctgcctcaccccaaaccccctgcggagagcagt
ggtggcaagctcttgccttgcacaggtgaatacatgaacatgtcgccagtgggggactcc
aacaccagcagcccctcagactgctactatggccctgaggacccccagcacaagccagtc
ctctcctactactcactgccaaggtcctttaagcacacccagcggccgggggagctggag
gaaggtgcccggcaccagcacctccgcctctcctctagctctggtcgccttctctatgct
gcgacagctgaagattcttcttcttccaccagcagcgacagcctgggtggtggatactgt
ggggctaggccagagcctggcctcccgcatccccaccatcatgtcctacagccccacctg
cctcgaaaggtggacacagctgctcagaccaacagccgcctggctcggcccacgaggctg
tccctgggggatcccaaggccagtaccttgcctcgggttcgagagcagcagcagcagcag
cagtccctgccgcaccctccggagcccaagagcccaggggagtatgtgaatattgaattt
gggagtgatcaacctggctacctgtctggccctgtggcttcccacagctctccctctatc
aggtgtccaccccagctccagccagctccccgagaggaagagactggcaccgaggagtac
atgaacatggacctgggacctggccggagggcaacctggcaggagaacacaggggctgac
ttgggcagagtgggccctgcacctcctggggcagctagcgtttgcaggcccacccgggca
gtgcccagcagccgaggcgactacatgaccatgcagatgggttgttcccgccagagctac
gtggatacctccccagtggcccctgtctgctatgctgacatgcgggcaggcattgctgcc
gaggaggccagcctgccccgggccacagcggctgctccttcctcatcctcagcagcctcc
tcttcccccactgagcctcaaggtgcagctgaactggctactcgctcctccctgctggga
gggccacaaggccccgggggcatgagtgccttcacccgggtgaccctcagtccgaaccgc
aaccagagtgccaaagtgatccgtgcagacccacaagggtgccggaggaggcatagctca
gagaccttctcctctacacccagtgccacccgggcgggcaacacggtgtctttcggaggg
ggcgcttcaggagggggcagcggtggcagcggcagtgaggatgtgaaacgccacagctct
gcttcctttgagaatgtgtggctgaggcccggggagctggtgggagcccccaaggagaca
gcccaagtgtgtggggctgctgggggtttggagaatggtcttaactacatagacctggat
ttggtcaaggacttcaaacagcgccctcaggagcgcccccctcagccgcagcctccccag
cctgtgccccctcatcctcatcagcccctgggcagcggtgagagcagctccaccagccgc
tccagtgaggatttaagcgcctatgccagcatcagtttccagaagcaaccagaggaccgc
cagtag

  All links  
Ontology (1)   
   KEGG BRITE (1)   
Pathway (20)   
   KEGG PATHWAY (20)   
Genome (1)   
   KEGG GENOME (1)   
Gene (23)   
   KEGG ORTHOLOGY (1)   
   RefGene (19)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   OC (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (6)   
   RefSeq(nuc) (2)   
   GenBank (2)   
   EMBL (2)   
Protein domain (3)   
   Pfam (3)   
All databases (55)   

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