KEGG   Oryctolagus cuniculus (rabbit): 100343442
Entry
100343442         CDS       T03373                                 
Name
(RefSeq) beta-secretase 1
  KO
K04521  beta-site APP-cleaving enzyme 1 (memapsin 2) [EC:3.4.23.46]
Organism
ocu  Oryctolagus cuniculus (rabbit)
Pathway
ocu05010  Alzheimer disease
Brite
KEGG Orthology (KO) [BR:ocu00001]
 09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    100343442
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:ocu01002]
    100343442
Enzymes [BR:ocu01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.23  Aspartic endopeptidases
    3.4.23.46  memapsin 2
     100343442
Peptidases and inhibitors [BR:ocu01002]
 Aspartic peptidases
  Family A1: pepsin family
   100343442
SSDB
Motif
Pfam: Asp TAXi_C TAXi_N PE-PGRS_C
Other DBs
NCBI-GeneID: 100343442
NCBI-ProteinID: XP_002708419
Ensembl: ENSOCUG00000022776
UniProt: G1U6Z1
Position
1:113094596..113115671
AA seq 501 aa
MAPALPWLLLWMGSGMLPAQGTQHGIRLPLRSGLGGAPLGLRLPRETEEDPEEPGRRGNF
VEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSST
YRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGIL
GLAYAEIARPDDSLEPFFDSLVKQTHVPNLFSLQLCGAGFPLNQSEVLASVGGSMIIGGI
DHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKK
VFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRIT
ILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSAC
HVHDEFRTAAVEGPFVTPDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQW
RCLRCLRHQHDDFADDISLLK
NT seq 1506 nt   +upstreamnt  +downstreamnt
atggccccagccctgccctggctcttgctgtggatgggctcgggcatgctgcctgcccaa
ggcacccagcacggcatccggctgcccctgcgcagcggcctggggggcgccccgctgggg
ctgcggctgccccgggagactgaggaggacccagaggaaccgggccgcaggggtaacttt
gtggagatggtggacaacctgaggggcaagtcgggccagggctactatgtggagatgact
gtgggcagccccccgcagacgctcaacatcctggtggacacaggcagcagcaactttgca
gtaggggctgccccgcaccctttcctgcatcgctactaccagaggcagctgtccagcaca
taccgggacctccgaaagggcgtgtatgtgccctacacccagggcaagtgggagggagaa
ctgggcactgacctggtaagcatccctcatggccccaacgtcaccgtgcgtgccaacatc
gctgccatcacggaatcagacaagttcttcatcaatggctccaactgggagggtatcctg
gggctggcctacgctgagattgccaggcctgacgactccctggagcccttcttcgactcc
ctggtaaagcagacccatgttcccaacctcttctccttgcagctctgtggcgctggcttc
cccctcaaccagtctgaggtgctggcctcagttggaggaagcatgatcattgggggaatc
gaccactcgctgtacacgggcagcctctggtacactcccatccggcgggaatggtattac
gaggtaatcattgtgcgggtggagatcaatggacaagatctgaaaatggactgtaaggag
tacaactacgacaaaagcatcgtggacagtggtaccaccaaccttcgtttgcccaagaag
gtgtttgaagctgcagtgaagtcgatcaaggcagcctcctcgacggagaagtttccggac
ggtttctggctaggggagcagctggtgtgctggcaagcaggcactaccccttggaacatt
ttcccagtcatctcactctacctcatgggtgaggtcaccaatcagtccttccgcatcacc
atccttccacagcaatacctgcggccagtggaagatgtggccacgtcgcaagatgactgc
tacaagttcgccatctcacagtcatcgaccggcactgtcatgggagctgtcatcatggag
ggcttctatgttgtctttgatcgggcccgaaaacgaattggctttgctgtcagtgcttgc
catgtgcacgacgagttcaggacagcagcagtagaaggcccttttgtcaccccggacatg
gaagactgtggctacaacattccacagacagatgagtcaactcttatgaccatagcctat
gtcatggctgccatctgcgccctcttcatgctgccactctgcctcatggtgtgtcagtgg
cgctgcctccgctgcctgcgccatcagcacgacgactttgctgacgacatctccctgctg
aagtga

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (1)   
   KEGG PATHWAY (1)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (10)   
   KEGG ORTHOLOGY (1)   
   RefGene (5)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (2)   
   UniProt (1)   
   RefSeq(pep) (1)   
DNA sequence (7)   
   RefSeq(nuc) (1)   
   GenBank (3)   
   EMBL (3)   
Protein domain (4)   
   Pfam (4)   
All databases (29)   

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