KEGG   Oryctolagus cuniculus (rabbit): 100357676
Entry
100357676         CDS       T03373                                 
Name
(RefSeq) DNA topoisomerase 2-alpha isoform X1
  KO
K03164  DNA topoisomerase II [EC:5.6.2.2]
Organism
ocu  Oryctolagus cuniculus (rabbit)
Pathway
ocu01524  Platinum drug resistance
Brite
KEGG Orthology (KO) [BR:ocu00001]
 09160 Human Diseases
  09176 Drug resistance: antineoplastic
   01524 Platinum drug resistance
    100357676
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03032 DNA replication proteins [BR:ocu03032]
    100357676
   03036 Chromosome and associated proteins [BR:ocu03036]
    100357676
Enzymes [BR:ocu01000]
 5. Isomerases
  5.6  Isomerases altering macromolecular conformation
   5.6.2  Enzymes altering nucleic acid conformation
    5.6.2.2  DNA topoisomerase (ATP-hydrolysing)
     100357676
DNA replication proteins [BR:ocu03032]
 Eukaryotic type
  DNA Topoisomerases
   100357676
Chromosome and associated proteins [BR:ocu03036]
 Eukaryotic type
  Chromosome condensation proteins
   Other regulators of chromosome condensation
    100357676
  Centrosome formation proteins
   Centriole proteins
    100357676
SSDB
Motif
Pfam: DNA_topoisoIV TOPRIM_C DNA_gyraseB DTHCT HATPase_c Toprim
Other DBs
NCBI-GeneID: 100357676
NCBI-ProteinID: XP_051681622
Ensembl: ENSOCUG00000002814
Position
19:complement(39068850..39103250)
AA seq 1554 aa
MSFYCFWEQFALWSASAPVRAGLEVARQPVNENMQMNKIKKNEDAKKRLSIERIYQKKTQ
LEHILLRPDTYIGSVELVTQHMWVYDEDVGINYREVTFVPGLYKIFDEILVNAADNKQRD
PKMSCIRVTIDPENNLISIWNNGKGIPVVEHKVEKMYVPALIFGQLLTSSNYDDDEKKVT
GGRNGYGAKLCNIFSTKFTVETASREYKKMFKQTWMDNMGRAGEMELKSFSGEDYTCITF
QPDLSKFKMQSLDKDIVALMVRRAYDIAGSTKDVKVFLNGNKLPVKGFRSYVDMYLKDKV
DETGNPLKVIHEQVNHRWEVCLTMSEKGFQQISFVNSIATSKGGRHVDYVADQIVAKLVD
VVKKKNKGGVAVKAHQVKNHMWIFVNALIENPTFDSQTKENMTLQAKSFGSTCQLSEKFI
KAAIGCGIVESILNWVKFKAQVQLNKKCSAVKHNRIKGIPKLDDANDAGSRNSAECTLIL
TEGDSAKTLAVSGLGVVGRDKYGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYK
KNYEDEDSLKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLRHRFLEEFITPIVK
VSRNKQEMAFYSLPEFEEWKSSTPNHKKWKVKYYKGLGTSTSKEAKEYFADMKRHRIQFK
YSGPEDDAAISLAFSKKQIDDRKEWLTHFMEDRRQRKLLGLPEDYLYGQTTTYLTYNDFI
NKELILFSNSDNERSIPSMVDGLKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSSYHH
GEMSLMMTIINLAQNFVGSNNLNLLQPIGQFGTRLHGGKDSASPRYIFTMLSPLARLLFP
PKDDHTLRFLYDDNQRVEPEWYIPIIPMVLINGAEGIGTGWSCKIPNFDVREIVNNIRRL
MDGEEPLPMLPSYKNFKGTIEELAPNQYVINGEVAILNSTTIEISELPVRTWTQTYKEQV
LEPMLNGTEKTPPLITDYREYHTDTTVKFVVKMTEEKLAEAERVGLHKVFKLQTSLTCNS
MVLFDHVGCLKKYDTVLDILKDFFELRLKYYGLRKEWLLGMLGAESAKLNNQARFILEKI
DGKIIIENKPKKELIKVLIQRGYDSDPVKAWKEAQQKVPDEEENEESDTEKETEKSDSVT
DSGPTFNYLLDMPLWYLTKEKKDELCRQRNEKEQELETLKRKGPSDLWKEDLAAFIEELE
AVEAKEKQDEQVGLPGKGGKAKGKKTQMAEVLPSPRGKRVIPRVTTEMKAEAEKKIKRKI
KSENTEGSPKEDGTELEDLKQRLEKKQKREPGTKTKKQTTLPFKPIKKAKKRNPWSDSES
DMSSNESNFDVPPREIEPRRAATKTKFTVDLDSDDDFSDFDEKTQDDDFVPSYASPPQTK
TSPKPTKKELKPQKSAMSVADLEVDDAKDEAPLSSSPPAADFPGETETVNPVTKKNVTVK
KTAAKSQSSTSTTGAKKRAAPKGTKKNPALNSDVSQKPEPAKTKTQRKRKPSTSDDSDSN
FEKIVSKAVTSKKSKGENDDFLLDLDSSVAPRAKSSRAKKPIKYLEESDEDDLF
NT seq 4665 nt   +upstreamnt  +downstreamnt
atgtcgttttactgtttctgggaacagttcgccctctggtcggcctctgcgccggtccgt
gcgggactcgaagtggcgcgtcagcctgtcaatgaaaatatgcaaatgaacaaaataaag
aaaaatgaagatgcgaagaagagactgtctattgaaagaatctatcaaaagaaaacgcag
ttggaacatattttgctccgccccgatacctacattggctctgtagaattagtgacccag
cacatgtgggtttacgatgaagatgttggtattaactacagggaagtcacttttgttcct
ggtttgtacaaaatctttgacgagattctagttaatgctgcggacaataaacaaagggac
cccaaaatgtcttgcattagagtcaccattgatccagaaaataatttaattagcatatgg
aataatggaaaaggtattcctgttgttgaacacaaagttgagaagatgtatgtcccagct
ctcatatttggacagctcctaacgtccagtaactatgatgatgatgaaaagaaagtaaca
ggtggtcgaaatggctatggagccaaattgtgtaacatattcagtaccaaatttactgtg
gaaacagccagtagagaatataaaaaaatgttcaaacagacttggatggataacatgggg
agagctggtgagatggagctcaagtcctttagtggagaagattatacatgtatcaccttt
cagcctgatttgtctaagtttaaaatgcaaagcctggacaaagatattgttgcactgatg
gttagaagagcatatgatattgctgggtccactaaagatgtcaaagtcttccttaatgga
aataagctgccagtgaaaggattccgtagttatgtggatatgtatttgaaggataaggta
gatgaaactggtaacccactgaaagtaatacatgagcaagtaaaccacagatgggaagta
tgtttaacaatgagtgaaaaaggctttcagcaaattagctttgtcaacagcattgccacc
tccaagggtggcagacatgttgattatgtagctgatcagattgtggctaaacttgttgat
gttgtaaagaagaagaacaagggtggtgttgcagtaaaagcacatcaggtgaaaaatcac
atgtggatttttgtgaacgccttaattgaaaacccaacctttgactctcagacaaaagaa
aacatgactttacaagccaagagctttggatcaacatgccagttgagtgaaaaattcatc
aaagctgcaattggctgtggtattgtagaaagcatactgaactgggtgaagtttaaggcc
caagtccagttaaacaagaagtgttcagctgtaaagcataacagaatcaagggaattccc
aaacttgatgatgccaatgatgcagggagccgaaactctgctgaatgtacacttatcctg
actgagggagactcagccaagactttagctgtttcagggcttggtgtggttggaagagac
aaatacggggttttccctcttagaggaaaaatactcaatgttcgagaagcttctcataaa
cagattatggaaaatgctgaaattaacaatattatcaagattgtgggtcttcagtacaag
aaaaactatgaagatgaagattcattaaagactcttcgttatgggaagataatgattatg
acagatcaggaccaagatggttcccatatcaaaggcttgctgattaattttatccatcac
aactggccttcgcttctgcgacatcgttttctggaagaatttatcactccaattgtaaag
gtttcgagaaacaagcaagaaatggcattctatagccttcccgaatttgaagaatggaag
agttctactccaaatcataaaaagtggaaagtcaagtattacaaaggtttgggcactagc
acatcaaaggaagctaaagaatactttgcagatatgaagagacatcgtatccaattcaaa
tattctggtcctgaagatgatgctgcaatcagcctggcctttagcaaaaagcaaatagat
gatcgaaaagaatggttaactcatttcatggaggatagaagacaacgaaagttacttggc
cttcctgaggattacttatatgggcaaaccaccacatatctgacatacaatgacttcata
aacaaagaacttatcctcttctcaaattctgataatgagagatctatcccgtcaatggta
gatggtttgaaaccagggcagagaaaggttttgtttacttgtttcaaacggaatgacaag
cgagaagtgaaggttgcccagttagctgggtcagtggcagaaatgtcttcttaccatcat
ggtgagatgtcgctgatgatgaccattatcaatttggctcagaattttgtgggtagcaat
aacctgaacctcttacagcccattggtcagtttggtaccaggctgcatggtggcaaggat
tctgctagtcctcgatacatcttcaccatgcttagccctttggctcggctattatttcca
ccaaaagatgaccacacgttaagattcttatatgatgacaaccaacgagttgagcctgaa
tggtacattcctattatacccatggtgctgataaatggtgctgaaggaattggtactggg
tggtcctgcaaaatccccaactttgatgttcgtgaaattgtgaataacatcagacgtttg
atggatggagaagaaccattgccaatgcttccaagttacaagaacttcaagggtactatt
gaagagctggctccaaatcagtatgttattaatggtgaagtagctattcttaattccaca
accattgaaatctcggagcttcccgtcagaacgtggacccagacatataaagaacaagtt
ctagaacccatgttgaatggcaccgagaagacaccccctctcataacagactacagggaa
taccacacagataccactgtgaagtttgttgtgaagatgactgaagaaaaactggcagag
gcagaaagagttgggttacacaaagtcttcaaactccaaaccagtctcacctgcaactct
atggtgctttttgaccatgtaggctgtttaaagaaatatgacacagtcttggatattcta
aaagacttctttgaactccggcttaaatattatggcttaagaaaagagtggcttctagga
atgcttggtgctgaatctgctaaactgaacaatcaggctcgttttatcttagagaaaata
gatggcaaaataatcattgaaaataagcctaagaaagaattaattaaagttctgattcag
agaggatatgattcggatcctgtgaaggcctggaaagaagcccagcaaaaggtcccagat
gaagaagaaaatgaagagagtgacactgaaaaggaaactgaaaaaagtgactctgtaaca
gattctgggccaaccttcaactacctgcttgatatgcccctttggtatctaaccaaggaa
aagaaagatgagctgtgcagacaaagaaacgaaaaagagcaagagctggaaacattaaag
agaaagggcccatcggatttgtggaaagaagacctggctgcttttattgaagaactggag
gctgttgaagccaaggaaaaacaagatgagcaagtaggacttcctgggaaaggggggaaa
gcaaaagggaaaaaaacacaaatggctgaagttttgccttctccacggggaaaaagagtc
attcctcgagtgaccacggagatgaaggcagaagcagaaaagaaaatcaaaaggaaaatt
aagagtgaaaatactgaaggaagccctaaggaagatggtacagaactagaagacttaaaa
caaagattagagaagaaacagaaaagagaaccaggtaccaagacaaagaagcaaactaca
ctgccatttaaaccaataaaaaaagcaaagaagagaaacccctggtctgattcagaatca
gatatgagcagtaacgaaagcaattttgatgtccctccaagagaaatagagccacggaga
gcagcaacaaaaaccaaattcacagtggatttggattcagatgatgatttctcagatttt
gatgaaaaaactcaagacgacgattttgtcccatcatatgctagtccacctcagaccaaa
acttccccaaaacccactaagaaagaactgaagccacagaaaagtgccatgtcagtagca
gaccttgaagttgatgatgctaaggatgaggcaccactttcttcaagccctcctgctgct
gatttcccaggtgaaactgaaactgtaaacccagttactaaaaagaatgtgaccgtgaag
aagacagcagcgaaaagtcagtcttccacctccactactggtgccaaaaaaagggctgca
ccaaaaggaaccaaaaagaatccagccttgaattctgatgtctctcaaaagcctgaacct
gccaaaacgaagactcagcgcaaaaggaagccgtcaacttctgacgattctgattctaat
tttgagaaaattgtttccaaagcagtcacaagcaagaaatccaaaggggagaatgatgac
ttccttctcgacttagactcaagtgtggctcctcgggcaaaatccagcagggcaaagaaa
cctataaagtaccttgaagagtcagatgaagatgatctgttttaa

  All links  
Ontology (4)   
   KEGG BRITE (4)   
Pathway (1)   
   KEGG PATHWAY (1)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (27)   
   KEGG ORTHOLOGY (1)   
   RefGene (22)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (5)   
   RefSeq(pep) (5)   
DNA sequence (9)   
   RefSeq(nuc) (5)   
   GenBank (2)   
   EMBL (2)   
Protein domain (6)   
   Pfam (6)   
All databases (54)   

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