KEGG   Oreochromis niloticus (Nile tilapia): 100691156
Entry
100691156         CDS       T06104                                 
Symbol
top2a
Name
(RefSeq) DNA topoisomerase 2-alpha
  KO
K03164  DNA topoisomerase II [EC:5.6.2.2]
Organism
onl  Oreochromis niloticus (Nile tilapia)
Brite
KEGG Orthology (KO) [BR:onl00001]
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03032 DNA replication proteins [BR:onl03032]
    100691156 (top2a)
   03036 Chromosome and associated proteins [BR:onl03036]
    100691156 (top2a)
Enzymes [BR:onl01000]
 5. Isomerases
  5.6  Isomerases altering macromolecular conformation
   5.6.2  Enzymes altering nucleic acid conformation
    5.6.2.2  DNA topoisomerase (ATP-hydrolysing)
     100691156 (top2a)
DNA replication proteins [BR:onl03032]
 Eukaryotic type
  DNA Topoisomerases
   100691156 (top2a)
Chromosome and associated proteins [BR:onl03036]
 Eukaryotic type
  Chromosome condensation proteins
   Other regulators of chromosome condensation
    100691156 (top2a)
  Centrosome formation proteins
   Centriole proteins
    100691156 (top2a)
SSDB
Motif
Pfam: DNA_topoisoIV TOPRIM_C DNA_gyraseB DTHCT HATPase_c Toprim
Other DBs
NCBI-GeneID: 100691156
NCBI-ProteinID: XP_005448251
Ensembl: ENSONIG00000019923
UniProt: I3KVE8
Position
LG8:19737203..19749800
AA seq 1584 aa
MAEPLKAFFENKPVEKLKKDPKRLSVERIYQKKTQLEHILLRPDSYIGSVEPVTQQMWVF
DEDAGLNCRDVTFVPGLYKIFDEILVNAADNKQRDKSMSCIKVNIDPENNTISVWNNGKG
IPVVEHKVEKVYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVETACK
QSKKCFKQTWYDNMGRAGEASIKPFDGEEYTCITFRPDLAKFKMSILDKDTVALMTRRAY
DIAGATKGVRVFFNSKKLPVTGFRSYVDMYVKDKVDELGGPLTVIHETVNERWEVCLTMS
EKGFQQVSFVNSIATTKGGRHIDYVADQVVSKLIEVVKKKNKAGVTVKPFQVKNHMWLFV
NCLIENPTFDSQTKENMTLQQKSFGSKCPLSEKFIKQATSCGIVESIMNWVKFKAQTQLN
KKCSAVKHTKIKGVPKLDDANDAGGKNSIGCTLILTEGDSAKTLAVSGLGVVGRDRYGVF
PLRGKMLNVREASHKQIMENAEINNIIKILGLQYKKNYSDPESLKSLRYGKIMIMTDQDQ
DGSHIKGLLINFIHHNWPSLLHHNFLEEFITPIIKASFKKTQLSFYSIPEFNAWKESQQN
HKSWKIKYYKGLGTSTSQEAKEYFSDMQRHRIPFKYSGPEDDEAITLAFSKKKVEERKEW
LTNFMINRRQRREHNLPEEYLYGQSTKSLSYNDFVNKELVLFSNSDNERSIPCLVDGLKP
GQRKVLYCCFKRNDKREVKVAQLAGSVAEMSAYHHGEVSLMMTIIGLAQNFVGSNNMNLL
QPLGQFGTRLHGGKDSASPRYIFTMLSPLARLVFPAVDDNLLKYNYDDNQRVEPEWYIPI
IPTVLVNGAEGIGTGWASKIPNYDIREIISNINRMLDGEEPMPMLPNYKDFRGTIEQVMD
NQYLNSGEISILDSTTIEISELPVKTWTQTYKENVLEPMLNGTEKVPPLITDYKDYHTDT
TVRFVVKMTEEKLREAEAAGLHKVFKLQSPLTCNSMVLFDHVGSLKKYESVQDILRDFFE
LRMKYYVLRKDWLAGMLGAESAKLSNQARFILEKIQGTLVIENKPKKELIRMLQQMGYDS
DPVKTWKQAQEKNEEEMEEEEEEGEGGEKDDSTGPDYNYLLSMPMWFLTKEKKEELCKQR
DAKMTELNTLKKKNPADLWREDLAAFSEELARVEAKEKENATIPVKTGKGKAVKVKKETL
PTPQGRRVIPRVTSTMKAEANRKADLKKGEGKRGKKIKSEDVVMKMEFGEDAENTEPVEE
TGLAARLSKKTKTQAGEKASKTGKQTTLQFKPVTKKPKKNAWSDEDVGLSDSEEEAEEVA
APRERIERKTKAAVKYSMSDSEDEFDDWGKKDAPKKKAFISDDDDDDDDASFAPDPSTVS
DNDVDSPAPPPKAPEPTKKVAKSKLTVKKTDTKSSSLSDDQEPASKPPTQRKTKEAAPKK
PAAAKKPAASKKKAADVKQPSILDALSKPKPASKAPAAKKIPSFDSSDSESEKKAPVTKQ
KPVLKRKKNLSDDSDSSSSDNLMSRLKSKTTAGTKKSKKWEEDESFQVSDPEEAAPVAAA
PRDKPSRARKPITYNLDSDSDSDF
NT seq 4755 nt   +upstreamnt  +downstreamnt
atggctgaaccgttgaaggccttttttgagaacaagccggtggaaaagctgaagaaggat
cctaagcggctgtcagtggagaggatctatcagaagaagacgcagctggagcacattttg
ctcagaccggactcctacataggctctgtagagcctgtcactcagcaaatgtgggtgttt
gatgaggatgctggactgaactgccgtgatgtgacatttgtgcctgggctctacaagatt
tttgatgagatccttgtaaatgcagctgataacaagcagagagataagagcatgtcctgc
atcaaggtcaacattgatcctgaaaacaacaccatcagtgtatggaataatgggaagggt
attcctgtggtggagcacaaagtggagaaagtttatgtacctgctctcatctttggacag
cttctcacttcaagtaactatgatgatgacgagaagaaagtcactggtggacgaaatgga
tacggtgccaagctttgcaacatcttcagtacaaagttcactgtcgagactgcttgtaaa
cagtcgaagaagtgcttcaagcagacttggtatgacaatatgggcagagcaggggaggct
agcatcaaaccgtttgatggagaggaatacacttgcatcaccttcagaccagatctggcc
aagtttaagatgagcatcttggacaaagacacagtggctctgatgaccaggagggcctat
gatattgctggagccactaagggtgtccgggtgttctttaatagcaagaagctaccagtt
acaggtttccgtagctatgtggacatgtatgtgaaagacaaggtggatgaactgggtggt
cctcttactgtcatccatgagactgtcaacgagcgctgggaggtctgcctcaccatgagc
gagaaaggtttccagcaagtcagctttgtcaacagcattgccacaacaaagggaggcagg
cacattgattatgtggctgaccaggtggttagcaagctcattgaagtggtgaagaagaag
aacaaagctggggtgacagtcaagcctttccaggtgaagaaccatatgtggctgtttgtc
aactgtctgattgaaaaccccaccttcgactctcagaccaaagagaatatgactctgcaa
cagaagagctttggctccaagtgtcccctgagtgagaagttcattaaacaggccacatcc
tgtgggattgtggaaagtatcatgaactgggtgaagttcaaggctcagacccagctcaac
aagaagtgctcggctgttaaacacacaaaaatcaaaggtgtgccaaaactggatgacgcc
aacgatgcaggtgggaagaactccattggctgcacgctgattcttacagagggagactca
gccaagacacttgctgtgtctgggctgggagtggtcggaagggaccgctatggcgtcttc
cctctcagaggaaaaatgctcaatgtccgggaggcttcacataaacagattatggaaaac
gcagaaatcaacaacatcatcaaaatcctcggtcttcagtacaaaaagaactacagtgac
ccagaatccctcaagagtctgcgctacggcaagatcatgatcatgacagatcaggatcaa
gacggctcccacattaagggcttgttgatcaacttcatccaccacaactggccttcgctg
ctgcatcacaactttctggaagagttcatcacccccatcatcaaggcgtctttcaagaaa
actcagctgtctttctacagtattcctgaattcaatgcatggaaggagagccagcagaac
cacaaatcttggaaaataaaatactacaaaggtttgggaaccagcacatcacaggaagcc
aaggagtacttctctgatatgcagagacatcgtatcccattcaagtactcaggacctgaa
gatgatgaagctatcacccttgcctttagcaagaagaaagtggaagagcgaaaagagtgg
cttaccaactttatgattaacagacgccagcgcagagagcacaacctgcctgaggagtac
ctgtacggtcagtcaaccaagtccctgtcgtacaacgactttgttaacaaggagctggta
cttttctccaactctgataacgagaggtccattccctgcctggtggatggactgaaaccg
ggtcagaggaaggtgttgtactgttgtttcaagaggaacgacaagcgagaggtgaaggtg
gcacagctggcaggctcagtggctgagatgtcggcctatcaccatggagaggtctctctg
atgatgaccatcattggtttagcccagaactttgtgggaagcaacaacatgaatctcttg
cagcctctgggacagtttggaaccaggctgcacggtggcaaggactctgccagccctcga
tacatcttcactatgctcagccccctcgcccgccttgttttcccagcagtggatgacaac
ctgctcaagtataactatgatgacaaccagcgggtagagcccgaatggtacattcccatc
atccccactgtgcttgtgaacggagccgaaggcattggcacaggttgggccagcaagatt
ccaaactacgacatacgtgagatcatcagcaacatcaaccgtatgctcgacggcgaggaa
cctatgcccatgcttccaaattacaaagacttcagaggcacaattgagcaggtgatggat
aaccagtacttgaatagtggagagatctccatccttgattcaaccactattgaaatctct
gaattgcctgtaaaaacatggacacagacctacaaggagaatgtgttggagccgatgctg
aatggcacagagaaggttcctcctctcatcacagactacaaggactaccacactgacacc
actgtgcgctttgtggtcaagatgacagaagagaagctgagggaggctgaggctgctggc
ctccataaagtcttcaagctgcagagccccctcacctgcaactctatggttctgtttgac
cacgtgggtagcctgaaaaagtacgagtctgtgcaggatatcctcagagatttctttgag
ttgaggatgaagtactacgtgctgagaaaggactggttggcaggcatgctgggagcagag
agtgccaagctcagcaaccaggctcgcttcatcctggagaaaattcagggcaccttggtc
attgagaacaagccaaagaaggagctgatccgcatgctccaacagatgggctatgactcc
gacccagtcaagacttggaaacaggctcaggagaagaatgaggaggagatggaggaggag
gaggaggagggggaaggaggagaaaaagacgactctactggaccggactacaattatctg
ctgagcatgcccatgtggttcttaacaaaagagaaaaaggaggagctgtgcaaacagagg
gatgctaagatgacggagctgaacaccctgaagaaaaagaatccagcagacctgtggagg
gaggaccttgctgccttctctgaggaactggcgcgggttgaggcaaaggaaaaggaaaat
gctaccattcctgtaaaaactggaaaaggcaaagcagtaaaggtgaagaaggagactttg
cccactccacagggccgccgcgtcattccacgtgttaccagcaccatgaaggctgaagct
aacaggaaggctgatctgaagaaaggagagggcaagagaggaaagaaaatcaagagtgaa
gatgttgtgatgaagatggagtttggagaggatgcagaaaatacagagccggttgaggaa
acgggcttagctgcacggctgagcaagaaaaccaagacccaagcaggagaaaaagcatca
aagacgggcaagcagaccactcttcagttcaagcctgttaccaagaagcccaagaaaaat
gcgtggtcagatgaggatgttggcctgtcggacagtgaagaggaggcagaggaagtggct
gcccccagagagcgcatagaacggaaaaccaaagctgcggtgaagtacagcatgtctgac
agtgaagatgaatttgatgactgggggaagaaggacgctccaaaaaagaaggctttcatc
agtgatgatgatgatgatgacgatgatgcaagcttcgccccagatcccagcactgtgtcg
gacaatgatgtggactctccagctccgcctcccaaagccccagaacccacgaagaaggta
gcaaaaagcaaattgacagttaaaaaaacagacacaaagtccagctctctgtcagacgat
caggagccagcatccaagcctccaactcaacgtaaaaccaaagaggccgcaccgaagaaa
cccgccgctgccaagaaaccagctgcatccaagaagaaggctgcagatgtgaagcagcca
tctatcttggatgctctctctaagcccaaacctgcgtccaaggctcctgctgccaagaag
atcccgtcattcgactctagtgactcagagagtgaaaagaaagctcccgtcacaaaacag
aaacctgttcttaaacgtaaaaagaacctcagtgatgactctgacagcagctcctcagat
aacctcatgtcacgcctcaaatccaagacgactgctggcaccaagaagagcaagaagtgg
gaagaggatgagagtttccaggtttcagaccctgaagaagccgctcctgtagctgcagca
ccacgggataaaccctcacgggcccggaaacccatcacctacaacctggactcagattca
gattcagatttttaa

  All links  
Ontology (4)   
   KEGG BRITE (4)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (4)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
Protein sequence (2)   
   UniProt (1)   
   RefSeq(pep) (1)   
DNA sequence (5)   
   RefSeq(nuc) (1)   
   GenBank (2)   
   EMBL (2)   
Protein domain (6)   
   Pfam (6)   
All databases (23)   

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