KEGG   Orcinus orca (killer whale): 101270209
Entry
101270209         CDS       T05247                                 
Symbol
TOP2B
Name
(RefSeq) DNA topoisomerase 2-beta isoform X2
  KO
K03164  DNA topoisomerase II [EC:5.6.2.2]
Organism
oor  Orcinus orca (killer whale)
Pathway
oor01524  Platinum drug resistance
Brite
KEGG Orthology (KO) [BR:oor00001]
 09160 Human Diseases
  09176 Drug resistance: antineoplastic
   01524 Platinum drug resistance
    101270209 (TOP2B)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03032 DNA replication proteins [BR:oor03032]
    101270209 (TOP2B)
   03036 Chromosome and associated proteins [BR:oor03036]
    101270209 (TOP2B)
Enzymes [BR:oor01000]
 5. Isomerases
  5.6  Isomerases altering macromolecular conformation
   5.6.2  Enzymes altering nucleic acid conformation
    5.6.2.2  DNA topoisomerase (ATP-hydrolysing)
     101270209 (TOP2B)
DNA replication proteins [BR:oor03032]
 Eukaryotic type
  DNA Topoisomerases
   101270209 (TOP2B)
Chromosome and associated proteins [BR:oor03036]
 Eukaryotic type
  Chromosome condensation proteins
   Other regulators of chromosome condensation
    101270209 (TOP2B)
  Centrosome formation proteins
   Centriole proteins
    101270209 (TOP2B)
SSDB
Motif
Pfam: DNA_topoisoIV TOPRIM_C DNA_gyraseB DTHCT Toprim HATPase_c
Other DBs
NCBI-GeneID: 101270209
NCBI-ProteinID: XP_004271952
Position
5:3252394..3351418
AA seq 1617 aa
MAKAGGGGGSGAGAGGLGALTWVNNAAKKEESETANKNDSSKKLSVERVYQKKTQLEHIL
LRPDTYIGSVEPLTQLMWVYDEDVGMNCREVTFVPGLYKIFDEILVNAADNKQRDKNMTC
IKVSIDPESNIISIWNNGKGIPVVEHKVEKVYVPALIFGQLLTSSNYDDDEKKVTGGRNG
YGAKLCNIFSTKFTVETACKEYKHSFKQTWMNNMMKTSEAKIKHFDGEDYTCITFQPDLS
KFKMEKLDKDIVALMTRRAYDLAGSCKGVKVMFNGKKLPVNGFRSYVDLYVKDKLDETGV
ALKVIHELANERWDVCLTLSEKGFQQISFVNSIATTKGGRHVDYVVDQVVGKLIEVVKKK
NKAGVSVKPFQVKNHIWVFINCLIENPSFDSQTKENMTLQPKSFGSKCQLSEKFFKAASN
CGIVESILNWVKFKAQTQLNKKCSSVKYSKIKGIPKLDDANDAGGRHSLECTLILTEGDS
AKSLAVSGLGVIGRDRYGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKSYDD
AESLKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLKHGFLEEFITPIVKASKNK
QELSFYSIPEFDEWKKHIENQKAWKIKYYKGLGTSTAKEAKEYFADMERHRILFRYAGPE
DDAAITLAFSKKKIDDRKEWLTNFMEDRRQRRLHGLPEQFLYGTATKHLTYNDFINKELI
LFSNSDNERSIPSLVDGFKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSAYHHGEQAL
MMTIVNLAQNFVGSNNINLLQPIGQFGTRLHGGKDAASPRYIFTMLSSLARLLFPAVDDN
LLKFLYDDNQRVEPEWYIPIIPMVLINGAEGIGTGWACKLPNYDAREIVNNVRRMLEGLD
PHPMLPNYKNFKGTIQELGQNQYAVSGEIFVVDRNTVEITELPVRTWTQVYKEQVLEPML
NGTDKTPALISDYKEYHTDTTVKFVVKMTEEKLAQAEAAGLHKVFKLQTTLTCNSMVLFD
HMGCLKKYETVQDILKEFFDLRLSYYGLRKEWLVGMLGAESTKLNNQARFILEKIQGKIT
IENRSKKDLIQMLVQRGYESDPVKAWKEAQEKAAEEEETQNQHDDSSSDSGTPSGPDFNY
ILNMSLWSLTKEKVEELIKQRDAKGREVNDLKRKSPSDLWKEDLAAFVEELDKVEVQERE
DLLAGMAGKAIKGKVGKPKVKKLQLEETMPSPFGRRIVPEITAMKADASKKLLKKKKGDL
DTTAVKVEFDEEFSGAQVEGAGEEALIPSAPINKGPKPKREKKEPGTRVRKAPTSSGKPS
AKKVKKRNPWSDDESKSESDLEETEPVVIPRDSLLRRAAAERPKYTFDFSEEEDDDADDD
DDNNDLEELKVKASPITNDGEDEFVPSDGLDKDEYTFSPGKSKASPEKSSHDKGQDYGNL
FSFPSYSQKSEDDSAKFDSNEEDSASVFSPSFGLKQTEKVPSKTVAAKKGKPSLDTAPKP
KRTPKQKKVETVNSDSDSEFGVPKKTTAPKGKGRGAKKRKASGSENEGDYNPGRKTSRTT
SKKPKKTSFDQDSDVDIFPSDFTSEPPSLPRTGRARKEVKYFAESDEEEDVDFAMFN
NT seq 4854 nt   +upstreamnt  +downstreamnt
atggccaaggcgggcggcggcggcggcagcggcgcgggagctggcggcctcggggcgctg
acttgggtgaacaatgctgcaaaaaaagaagagtcagaaactgcaaacaaaaatgattct
tcaaagaagttgtctgttgagagagtgtatcagaaaaagacacaacttgaacatattctc
cttcgtcctgatacgtacattgggtcggtggagccattgacacagctcatgtgggtgtat
gatgaagatgtaggaatgaattgcagagaggttacctttgtgccgggtttatacaagatc
tttgatgaaattttggttaatgcagctgacaataaacagagggataagaacatgacctgt
attaaagtttctattgatcctgaatctaacatcataagcatctggaataatgggaaaggc
attccggtagtagaacacaaagtagagaaagtttatgttcctgcattaatttttggacag
cttttaacatccagtaactatgatgatgatgagaaaaaagtaacaggtggtcgcaatggt
tatggtgcaaaactttgtaatattttcagtacaaagtttacagtagaaactgcttgcaaa
gaatacaaacatagttttaagcagacatggatgaataatatgatgaagacttctgaagcc
aaaattaaacattttgatggtgaagattacacatgcataacattccaaccagatctgtcc
aagtttaagatggagaaacttgacaaggacattgtggctctcatgaccagaagagcttac
gatttggctggttcgtgcaaaggagtcaaggttatgtttaatggaaagaaattgcctgta
aatggatttcgcagttatgtagatctttatgtgaaagacaagttggatgaaactggagtg
gccctaaaagttattcatgaacttgcaaatgaaagatgggatgtttgtctcacactgagt
gaaaaaggattccagcaaatcagctttgttaatagcattgcaacaacaaaaggtggacgg
catgtggattatgtagtagaccaagttgttggtaaactgattgaagtagttaagaaaaag
aacaaagctggtgtgtcagtgaaaccatttcaagtaaaaaaccatatatgggtttttatt
aactgccttatcgaaaatccaagttttgattctcagactaaggaaaacatgactttgcag
cccaaaagttttggatccaaatgccaactgtcagaaaagttttttaaagcagcctctaac
tgtggcattgtggaaagtatcctgaactgggtgaaatttaaggctcagacgcagctgaac
aagaagtgttcatcagtaaagtacagtaaaatcaaaggtattcccaaactggacgatgct
aatgatgctggtggcaggcactccctggagtgcacgctgatactgacggaaggggactct
gctaagtcgctggccgtgtccggactgggcgtgattgggagggacaggtacggggtcttc
cccctcaggggcaagatcctcaacgtgcgggaggcctctcacaagcagatcatggagaat
gcagaaataaacaatatcattaagatagttggtctacaatacaagaaaagttacgatgat
gcagaatcgctgaaaaccttacgctatgggaagattatgattatgactgatcaggatcaa
gatggttctcacataaaaggcctgcttattaatttcatccatcacaattggccatcactt
ttgaagcatggttttcttgaagagttcattactcctatcgtaaaggctagcaaaaataag
caggaactttccttctatagtattcctgaatttgatgagtggaaaaaacatatagaaaac
cagaaagcctggaaaataaaatactacaaagggttgggtaccagtacagctaaggaagcc
aaggaatattttgctgatatggaaaggcaccgcatcttatttagatatgctggtcctgaa
gatgatgctgccattaccttggcattcagtaagaagaagatcgatgacagaaaagaatgg
ttaacaaattttatggaagatcggagacagcgtaggttacatggcttaccagagcaattt
ttatatggtacagcaacaaagcatttgacttacaatgatttcatcaacaaggaattgatt
ctcttctcaaactcagacaatgaaaggtctataccatctcttgttgatggctttaaacca
ggccaacgaaaagttttatttacctgtttcaagaggaatgataaacgcgaagtaaaagtt
gcacagttggctggatctgttgccgagatgtctgcttatcatcatggagaacaagcactg
atgatgactattgtgaacttggctcagaactttgtggggagtaacaacattaacttgctt
cagcccatcggtcagtttggaactcggcttcacgggggcaaagatgctgcaagtcctcgt
tacattttcacgatgttaagctctttggcaagactgcttttccctgctgtggacgacaac
ctgcttaaattcctttatgatgataatcaacgcgtagagcccgagtggtatattcccata
atccccatggttttaataaatggtgctgagggtatcggcacaggatgggcttgtaaacta
cccaactatgatgctagggagattgtgaacaacgtcagacggatgctggaaggcttggat
cctcatcccatgcttccaaactacaaaaactttaaaggaacaatccaagaacttggtcaa
aaccaatatgcagtcagtggtgaaatatttgtggtggatagaaacacagtggagattaca
gagcttcccgttagaacttggacacaggtatacaaagaacaggttttagaacctatgcta
aatggaacagataaaacaccagcattaatttctgattataaagaataccatacggataca
actgtgaaatttgtggtgaaaatgactgaagagaaactagcacaagcagaagctgctgga
ttgcacaaagtttttaaacttcaaactactcttacttgtaattccatggtactctttgat
catatgggatgtctgaagaagtatgaaactgtgcaagacattttgaaagaattctttgat
ttacgattaagctattatggtttacgtaaggagtggcttgtaggaatgctgggagcagaa
tctacaaagcttaacaatcaagcccgtttcattttagagaagatacaagggaagattact
atagagaataggtcaaagaaagatttgattcaaatgttagtccagagaggttatgaatct
gacccagtgaaagcctggaaagaagcacaagaaaaggcagcagaagaggaagaaacacaa
aaccagcatgatgatagttcctctgattcaggaactccttcaggccctgattttaattat
attttaaatatgtctctatggtctcttactaaagaaaaagttgaagaactgattaaacag
agagatgcaaaagggcgagaggtcaatgatcttaaaagaaaatctccttcagatctttgg
aaagaagatttagcagcttttgttgaagaactggataaagtggaagtgcaagaacgagaa
gatcttctggctgggatggctggaaaagcaataaaagggaaagttggcaaacctaaggtg
aagaagcttcaactggaagagacaatgccctcacctttcgggagaagaatagttcctgaa
attactgccatgaaggcagatgccagtaagaagttgctgaagaagaaaaagggtgatctc
gataccacagcagtgaaagtggaatttgatgaagaattcagtggtgcacaagtagaaggt
gcaggagaagaggcattgatcccgtcagctcctataaataaaggtcccaaacccaaaagg
gagaaaaaggagcctggtaccagggtgagaaaagcacctacatcatctggtaaacccagc
gcaaagaaagtgaagaaacggaatccttggtcagacgatgaatccaagtcagaaagtgac
ttggaagaaacagaacctgtggttattccacgagattctttacttaggagagcggctgct
gaaaggcctaagtacacatttgatttctcagaagaagaggacgacgatgctgatgatgac
gatgacaataatgatttagaggaattgaaagttaaagcatctcccataacaaatgatgga
gaagatgaatttgtcccttcagatggcctagataaagatgaatatacgttttcaccaggc
aaatccaaagctagtccagaaaagtcttcccatgacaaaggtcaggattacgggaatctc
ttctcatttccttcatactctcagaagtcagaagatgattcagctaaatttgacagtaat
gaagaagattctgcttctgtcttttcaccatcatttggtctgaaacaaacagaaaaagtt
ccaagtaaaacagtagctgctaagaagggaaaaccatctttagatacagcccccaagccc
aagagaactcccaaacagaagaaagtagagactgtaaactctgactcggattccgaattt
ggcgttccaaagaagacaacagcacccaaaggtaaaggccgaggggcaaagaagaggaaa
gcatctggctctgaaaacgaaggtgattataaccctggcaggaaaacctctagaacaaca
agcaagaaaccgaagaaaacatcttttgatcaggattcagatgtggacatcttcccatca
gacttcacttctgaaccaccttctctgccgcggaccggtcgggctaggaaagaagtaaaa
tattttgcagagtctgatgaagaagaagatgttgattttgcgatgtttaattag

  All links  
Ontology (4)   
   KEGG BRITE (4)   
Pathway (1)   
   KEGG PATHWAY (1)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (16)   
   KEGG ORTHOLOGY (1)   
   RefGene (12)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   OC (1)   
Protein sequence (4)   
   RefSeq(pep) (4)   
DNA sequence (4)   
   RefSeq(nuc) (4)   
Protein domain (6)   
   Pfam (6)   
All databases (37)   

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