KEGG   Orcinus orca (killer whale): 101271463
Entry
101271463         CDS       T05247                                 
Symbol
IRS1
Name
(RefSeq) insulin receptor substrate 1
  KO
K16172  insulin receptor substrate 1
Organism
oor  Orcinus orca (killer whale)
Pathway
oor04022  cGMP-PKG signaling pathway
oor04068  FoxO signaling pathway
oor04140  Autophagy - animal
oor04150  mTOR signaling pathway
oor04151  PI3K-Akt signaling pathway
oor04152  AMPK signaling pathway
oor04211  Longevity regulating pathway
oor04213  Longevity regulating pathway - multiple species
oor04722  Neurotrophin signaling pathway
oor04910  Insulin signaling pathway
oor04920  Adipocytokine signaling pathway
oor04923  Regulation of lipolysis in adipocytes
oor04930  Type II diabetes mellitus
oor04931  Insulin resistance
oor04932  Non-alcoholic fatty liver disease
oor04935  Growth hormone synthesis, secretion and action
oor04960  Aldosterone-regulated sodium reabsorption
oor05010  Alzheimer disease
oor05206  MicroRNAs in cancer
oor05415  Diabetic cardiomyopathy
Brite
KEGG Orthology (KO) [BR:oor00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04068 FoxO signaling pathway
    101271463 (IRS1)
   04022 cGMP-PKG signaling pathway
    101271463 (IRS1)
   04151 PI3K-Akt signaling pathway
    101271463 (IRS1)
   04152 AMPK signaling pathway
    101271463 (IRS1)
   04150 mTOR signaling pathway
    101271463 (IRS1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    101271463 (IRS1)
 09150 Organismal Systems
  09152 Endocrine system
   04910 Insulin signaling pathway
    101271463 (IRS1)
   04923 Regulation of lipolysis in adipocytes
    101271463 (IRS1)
   04920 Adipocytokine signaling pathway
    101271463 (IRS1)
   04935 Growth hormone synthesis, secretion and action
    101271463 (IRS1)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    101271463 (IRS1)
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    101271463 (IRS1)
  09149 Aging
   04211 Longevity regulating pathway
    101271463 (IRS1)
   04213 Longevity regulating pathway - multiple species
    101271463 (IRS1)
 09160 Human Diseases
  09161 Cancer: overview
   05206 MicroRNAs in cancer
    101271463 (IRS1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    101271463 (IRS1)
  09166 Cardiovascular disease
   05415 Diabetic cardiomyopathy
    101271463 (IRS1)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    101271463 (IRS1)
   04932 Non-alcoholic fatty liver disease
    101271463 (IRS1)
   04931 Insulin resistance
    101271463 (IRS1)
SSDB
Motif
Pfam: IRS PH PH_11
Other DBs
NCBI-GeneID: 101271463
NCBI-ProteinID: XP_004262683
Position
7:complement(108904114..108983096)
AA seq 1247 aa
MASPPETDGFSDVRKVGYLRKPKSMHKRFFVLRAASEAGGPARLEYYENEKKWRHKSSAP
KRSIPLESCFNINKRADSKNKHLVALYTRDEHFAIAADSEAEQDSWYQALLQLHNRAKGH
HDGAAAPGAGGGGGSCSGSSGLGEAGEDLSYGDVPPGPAFKEVWQVILKPKGLGQTKNLI
GIYRLCLTSKTISFVKLNSEAAAVVLQLMNIRRCGHSENFFFIEVGRSAVTGPGEFWMQV
DDSVVAQNMHETILEAMRAMSDEFRPRSKSQSSSNCSNPISVPLRRHHLNNPPPSQVGLT
RRSRTESITATSPASLVGGKQGSFRVRASSDGEGTMSRPASVDGSPVSPSTNRTHAHRHR
GSSRLHPPLNHSRSIPMPSSRCSPSATSPVSLSSSSTSGHGSTSDCLFPRRSSASVSGSP
SDGGFISSDEYGSSPCDFRSSFRSVTPDSLGHTPPARGEEELSNYICMGGKGASTLTAPN
GHYILPRSGNGPRYIPAAGLGTSPALTGDEAASAADLDNRFRKRTHSAGTSPTISHQKTP
SQSSVASIEEYTEMMPAYPPGGGSGGRVPSYRHSAFVPTHSYPEEGLEMHPLERRVGHHR
PDTSNLHTDDGYMPMSPGVAPVPGSRKGSGDYMPMSPKSVSAPQQIINPIRRHPQRVDPN
GYMMMSPSGSCSPDIGGGPSSGGSSGAAPSGSSYGKLWTNGVGGHHSHALPHPKLPVESS
SGKLLSCTGDYMNMSPVGDSNTSSPSDCYCGPEDPQHKTVLSYYSLPRSFKHTQRPGELE
EGARHQHLRLSSSSGRLLYAAAAEDSSSSTSSDSLGGGYCAARPEPGLPHLHHQVLQPHL
PRKVDTAAQTNSRLARPTRLSLGDPKASTLPRAREQPQPQPQPPPPLLPPPEPKSPGEYV
NIEFGSDQPGYLSGPGASHSSPSVRCPSQLQPAPREEETGAEEYMNMDLGPGRRAAWRES
AGVQPGSMGPAPPGAASVCRPTRAVPSSRGDYMTMQMGCPRQSYVDTSPVAPISYADMRT
GGGGLVEEASLPGAAAATPSSSSKASASPAAPQGAEELAARSSLLGGPQGPGGSSAFTRV
NLSPNRNQSAKVIRADPQGCRRRHSSETFSSTPSATRAGNTVPFGAGAAAGGGGGGSSST
EDVKRHSSASFENVWLRPGELGGAPKELAQVCGAAGGLENGLNYIDLDLVKDFNQSPQER
PAQPQPSPPPPPHQPLGRSESGSTSRSSEDLSAYASISFQKPPEDLQ
NT seq 3744 nt   +upstreamnt  +downstreamnt
atggcgagccctcccgagaccgacggcttctccgacgtgcgcaaggtgggctacctgcgc
aagcccaagagcatgcacaagcgattcttcgtgctgcgggcggccagcgaggctgggggc
ccggcgcgcctcgagtactacgagaacgagaagaagtggcggcacaagtcgagcgccccc
aaacgctcgatccccctcgagagctgcttcaacatcaacaagcgggccgactccaagaac
aagcacctggtggccctctatacccgggacgagcactttgccatcgcggcggacagcgag
gccgagcaggacagctggtaccaggccctcctgcagctgcacaaccgtgccaagggccac
cacgacggggccgcggctcccggggcgggaggcggcgggggcagctgcagtggcagctcc
ggccttggcgaggctggggaggacttgagctacggggacgtgcccccaggacccgccttc
aaggaagtctggcaggtgatcctgaaacccaagggcctgggtcagacaaagaacctgatt
ggtatctaccgcctctgcctgaccagcaagaccatcagcttcgtgaagctgaactcggag
gctgccgcggtggtgctgcagctgatgaacatcaggcgctgtggccactcagagaacttc
ttcttcatcgaagtgggccgttccgcagtgacgggacccggggagttctggatgcaggtg
gatgactctgtggtggcccagaacatgcacgagacgatcctggaagccatgcgggccatg
agcgatgagttccgccctcgaagcaagagccagtcctcctccaactgctccaaccccatc
agtgtccccctgcgcaggcatcacctcaacaaccctccacccagccaggtggggctgacc
cgccgctcgcgcacagagagcatcactgccacctccccggccagcttggtgggcgggaag
cagggctccttccgggtccgcgcctctagtgatggcgaaggcaccatgtctcgccctgcc
tctgtggacggcagtcctgtgagtcccagcaccaacaggacccatgcccaccggcatcgc
ggcagttcccggctgcaccctcctctcaaccacagccgctccatccccatgccttcttct
cgctgctcgccttccgccaccagcccggtcagcctatcgtccagtagcaccagtggccac
ggctccacctcggactgtctcttcccacggcggtctagtgcttccgtgtccggttccccc
agtgatggcggtttcatctcctctgatgagtatggctccagtccctgcgacttccgaagt
tccttccgcagtgtcaccccggattccctgggccacaccccgccggcccgcggtgaggag
gagctgagcaactacatctgcatgggaggcaagggggcctccaccctcacggcccccaat
ggtcactacattttgcctcggagtggcaacggtccccgctacatcccggcagccggcttg
ggcacgagcccagccctgacaggggatgaagcagccagtgctgcagatctggacaatcgg
ttccgaaagcggactcactctgctggcacgtcacctaccatttcccaccagaagacccca
tcccagtcctctgtggcctccattgaggaatataccgagatgatgcctgcctacccacca
ggaggtggcagtggaggccgagtgcccagctaccggcactccgccttcgtgcccacccac
tcctacccagaggagggtctggaaatgcaccccttggagcggcgtgtgggccaccaccgc
ccagacacctccaacctccacaccgatgatggctacatgcccatgtccccaggggtggcc
ccagtgcccgggagccgaaagggcagtggggactacatgcccatgagccccaagagcgtg
tctgcccctcagcagatcatcaaccccatcagacgccatccccagagagtggaccccaat
ggctacatgatgatgtccccaagcggcagctgctctcctgacattggaggcgggcccagc
agcggcggcagcagcggtgccgccccttctgggagcagctatggcaagctctggacgaat
ggggtagggggccaccactctcacgccctgccacaccccaaactccctgtggagagcagt
agcggcaagctgttgtcttgtacgggtgactacatgaacatgtcgccagtgggggactcc
aacaccagcagcccttccgactgctactgtgggcctgaggacccccagcacaagacagtc
ctctcctactactcattgccaaggtcctttaagcacacccagcgccccggggagctggag
gagggcgcccggcaccagcacctccgcctttcctccagctcgggtcgacttctctatgct
gcggcggcggaagattcctcctcgtccaccagcagcgacagcctgggcgggggatactgc
gcggctaggcccgagcccggcctcccgcatctccaccatcaggtcctgcagccccatctg
cctcgaaaggtggacacagctgcccagaccaacagccgcctggcccggcccacgaggctg
tccctgggggatcccaaggccagcaccttaccccgggcccgagagcagccgcagccccag
ccgcagccgccgccgcccctgctgccccctccggagcccaagagcccaggggaatatgtg
aatattgaatttgggagcgatcagccgggctacttatcaggccccggggcttcccacagc
tcgccttctgtccggtgtccatcccagctccagccggctcccagagaggaggagacgggc
gcggaagagtacatgaacatggacctggggccgggccggagggccgcctggcgggagagc
gctggggtccagccgggcagcatgggcccggcaccccctggagctgctagcgtgtgcagg
cccaccagggcagtgcccagtagccggggtgactacatgaccatgcagatgggctgtccc
cggcagagctacgtggacacctcgccagtcgcccctatcagctatgcggacatgcggacc
ggcggcggtggcctcgtggaggaggccagcctgcctggggccgccgcggccacgccctcc
tcatcctcgaaggcctctgcttcccccgccgcgcctcaaggagcagaggagctggcggcc
cgctcttccctgctgggaggcccgcagggacccgggggctcgagtgccttcacgcgggtg
aacctcagtcccaaccgcaaccagagtgccaaagtgatccgtgccgacccgcaagggtgc
aggaggcggcacagctccgagaccttctcctcgacgcccagtgccacgcgggcaggcaac
acggtgcccttcggagcgggggctgcagccgggggcggcggtggtggcagcagcagcacg
gaggacgtgaaacgccacagctctgcttcctttgagaacgtgtggctgcggcctggggag
ctcgggggagcccccaaggagctggcccaagtgtgcggggccgccgggggtttggagaat
gggcttaactacatagacctggatttggtcaaggacttcaaccagagccctcaagagcgc
cccgctcagccgcagccttctcctcccccgccccctcatcagcctctgggacgcagcgag
agcggctccaccagccgctccagcgaggatttaagcgcctatgccagcatcagtttccag
aagccgccagaggacctccagtag

  All links  
Ontology (1)   
   KEGG BRITE (1)   
Pathway (20)   
   KEGG PATHWAY (20)   
Genome (1)   
   KEGG GENOME (1)   
Gene (24)   
   KEGG ORTHOLOGY (1)   
   RefGene (20)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   OC (1)   
Protein sequence (4)   
   RefSeq(pep) (4)   
DNA sequence (4)   
   RefSeq(nuc) (4)   
Protein domain (3)   
   Pfam (3)   
All databases (57)   

Download RDF
DBGET integrated database retrieval system