KEGG   Orcinus orca (killer whale): 101273171
Entry
101273171         CDS       T05247                                 
Symbol
ADCY8
Name
(RefSeq) adenylate cyclase type 8 isoform X1
  KO
K08048  adenylate cyclase 8 [EC:4.6.1.1]
Organism
oor  Orcinus orca (killer whale)
Pathway
oor00230  Purine metabolism
oor01100  Metabolic pathways
oor01522  Endocrine resistance
oor04015  Rap1 signaling pathway
oor04020  Calcium signaling pathway
oor04022  cGMP-PKG signaling pathway
oor04024  cAMP signaling pathway
oor04062  Chemokine signaling pathway
oor04072  Phospholipase D signaling pathway
oor04114  Oocyte meiosis
oor04211  Longevity regulating pathway
oor04213  Longevity regulating pathway - multiple species
oor04261  Adrenergic signaling in cardiomyocytes
oor04270  Vascular smooth muscle contraction
oor04371  Apelin signaling pathway
oor04540  Gap junction
oor04611  Platelet activation
oor04713  Circadian entrainment
oor04714  Thermogenesis
oor04720  Long-term potentiation
oor04723  Retrograde endocannabinoid signaling
oor04724  Glutamatergic synapse
oor04725  Cholinergic synapse
oor04727  GABAergic synapse
oor04742  Taste transduction
oor04750  Inflammatory mediator regulation of TRP channels
oor04911  Insulin secretion
oor04912  GnRH signaling pathway
oor04913  Ovarian steroidogenesis
oor04914  Progesterone-mediated oocyte maturation
oor04915  Estrogen signaling pathway
oor04916  Melanogenesis
oor04918  Thyroid hormone synthesis
oor04921  Oxytocin signaling pathway
oor04923  Regulation of lipolysis in adipocytes
oor04925  Aldosterone synthesis and secretion
oor04926  Relaxin signaling pathway
oor04927  Cortisol synthesis and secretion
oor04928  Parathyroid hormone synthesis, secretion and action
oor04934  Cushing syndrome
oor04935  Growth hormone synthesis, secretion and action
oor04970  Salivary secretion
oor04971  Gastric acid secretion
oor04972  Pancreatic secretion
oor04976  Bile secretion
oor05032  Morphine addiction
oor05163  Human cytomegalovirus infection
oor05166  Human T-cell leukemia virus 1 infection
oor05200  Pathways in cancer
oor05207  Chemical carcinogenesis - receptor activation
oor05414  Dilated cardiomyopathy
Brite
KEGG Orthology (KO) [BR:oor00001]
 09100 Metabolism
  09104 Nucleotide metabolism
   00230 Purine metabolism
    101273171 (ADCY8)
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    101273171 (ADCY8)
   04371 Apelin signaling pathway
    101273171 (ADCY8)
   04020 Calcium signaling pathway
    101273171 (ADCY8)
   04072 Phospholipase D signaling pathway
    101273171 (ADCY8)
   04024 cAMP signaling pathway
    101273171 (ADCY8)
   04022 cGMP-PKG signaling pathway
    101273171 (ADCY8)
 09140 Cellular Processes
  09143 Cell growth and death
   04114 Oocyte meiosis
    101273171 (ADCY8)
  09144 Cellular community - eukaryotes
   04540 Gap junction
    101273171 (ADCY8)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    101273171 (ADCY8)
   04062 Chemokine signaling pathway
    101273171 (ADCY8)
  09152 Endocrine system
   04911 Insulin secretion
    101273171 (ADCY8)
   04923 Regulation of lipolysis in adipocytes
    101273171 (ADCY8)
   04912 GnRH signaling pathway
    101273171 (ADCY8)
   04913 Ovarian steroidogenesis
    101273171 (ADCY8)
   04915 Estrogen signaling pathway
    101273171 (ADCY8)
   04914 Progesterone-mediated oocyte maturation
    101273171 (ADCY8)
   04921 Oxytocin signaling pathway
    101273171 (ADCY8)
   04926 Relaxin signaling pathway
    101273171 (ADCY8)
   04935 Growth hormone synthesis, secretion and action
    101273171 (ADCY8)
   04918 Thyroid hormone synthesis
    101273171 (ADCY8)
   04928 Parathyroid hormone synthesis, secretion and action
    101273171 (ADCY8)
   04916 Melanogenesis
    101273171 (ADCY8)
   04925 Aldosterone synthesis and secretion
    101273171 (ADCY8)
   04927 Cortisol synthesis and secretion
    101273171 (ADCY8)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    101273171 (ADCY8)
   04270 Vascular smooth muscle contraction
    101273171 (ADCY8)
  09154 Digestive system
   04970 Salivary secretion
    101273171 (ADCY8)
   04971 Gastric acid secretion
    101273171 (ADCY8)
   04972 Pancreatic secretion
    101273171 (ADCY8)
   04976 Bile secretion
    101273171 (ADCY8)
  09156 Nervous system
   04724 Glutamatergic synapse
    101273171 (ADCY8)
   04727 GABAergic synapse
    101273171 (ADCY8)
   04725 Cholinergic synapse
    101273171 (ADCY8)
   04720 Long-term potentiation
    101273171 (ADCY8)
   04723 Retrograde endocannabinoid signaling
    101273171 (ADCY8)
  09157 Sensory system
   04742 Taste transduction
    101273171 (ADCY8)
   04750 Inflammatory mediator regulation of TRP channels
    101273171 (ADCY8)
  09149 Aging
   04211 Longevity regulating pathway
    101273171 (ADCY8)
   04213 Longevity regulating pathway - multiple species
    101273171 (ADCY8)
  09159 Environmental adaptation
   04713 Circadian entrainment
    101273171 (ADCY8)
   04714 Thermogenesis
    101273171 (ADCY8)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    101273171 (ADCY8)
   05207 Chemical carcinogenesis - receptor activation
    101273171 (ADCY8)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    101273171 (ADCY8)
   05163 Human cytomegalovirus infection
    101273171 (ADCY8)
  09165 Substance dependence
   05032 Morphine addiction
    101273171 (ADCY8)
  09166 Cardiovascular disease
   05414 Dilated cardiomyopathy
    101273171 (ADCY8)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    101273171 (ADCY8)
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    101273171 (ADCY8)
Enzymes [BR:oor01000]
 4. Lyases
  4.6  Phosphorus-oxygen lyases
   4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)
    4.6.1.1  adenylate cyclase
     101273171 (ADCY8)
SSDB
Motif
Pfam: Guanylate_cyc Adcy_cons_dom AC_N TBK1_ULD
Other DBs
NCBI-GeneID: 101273171
NCBI-ProteinID: XP_004265364
Position
17:complement(77571477..77790241)
AA seq 1250 aa
MELSDVRCLSGSEELYTIHPTPPAGDGGSGSRPQRLLWQTAVRHITEQRFVHGHRGSGGG
SGSSSKASDPVGGGPNHHASQLAGDSALPLYALGPGERAHSPGCTKVFPERSGSGGGGGS
GGAGDLGFLHLDCAPSNSDFFLKGGYSYRGVIFPTLRNSFKSRDLERLYQRYFLGQRRKS
EVVMNVLDVLTKLTLLVLHLSLASAPMDPLKGILLGFFTGIEVVICALVVVRKDTTSHTY
LQYSGVVTWVAMTTQILAAGLGYGLLGDSIGYVLFTLFATYSMLPLPLTWAILAGLGTSL
LQVVLQGVIPRLAVISINQVVAQAVLFMCMNTAGIFISYLSDRAQRQAFLETRRCVEARL
RLETENQRQERLVLSVLPRFVVLEMINDMTNVEDEHLQHQFHRIYIHRYENVSILFADVK
GFTNLSTTLSAQELVRMLNELFARFDRLAHEHHCLRIKILGDCYYCVSGLPEPRQDHAHC
CVEMGLSMIKTIRYVRSRTKHDVDMRIGIHSGSVLCGVLGLRKWQFDVWSWDVDIANKLE
SGGIPGRIHISKATLDCLNGDYNVEEGHGKERNEFLRKHNIETYLIKQPEESLLSLPEDI
VKESVSSSDRRNSGATFTEGSWSPELPFDNIVGKQNTLAALTRNSINLLPNHLAQALHVQ
SGPEEINKRIEHTIDLRSGDKLRREHIKPFSLMFKDSSLEHKYSQMRDEVFKSNLVCAFI
VLLFITAIQSLLPSSRVMPMAIQFSILIMLHSALILITTAEDYKCLPLVLRKTCCWINET
YLARNVIIFASILINFLGAILNILWCDFDKSIPLKNLTFNSSAVFTDICSYPEYFVFTGV
LAMVTCAVFLRLNSVLKLAVLLIMIAIYALLTETIYAGLFLRYDNLNHSGEDFLGTKEAS
LLLMAMFLLAVFYHGQQLEYTARLDFLWRVQAKEEINEMKELREHNENMLRNILPSHVAR
HFLEKDRDNEELYSQSYDAVGVMFASIPGFADFYSQTEMNNQGVECLRLLNEIIADFDEL
LGEDRFQDIEKIKTIGSTYMAVSGLSPEKQQCEDKWEHLCALADFSLALTESIQEINKHS
FNNFELRIGISHGSVVAGVIGAKKPQYDIWGKTVNLASRMDSTGVSGRIQVPEETYLILK
DQGFAFDYRGEIYVKGISEQEGKIKTYFLLGRVQPNPFILPPRRLPGQYSLAAVVLGLVQ
SLNRQRQKQLLNENNNTGIIKGHYNRRTLLTPSGPEPGAPAEGTDKSELP
NT seq 3753 nt   +upstreamnt  +downstreamnt
atggagctctccgatgtgcgctgccttagcggcagcgaggagctctacaccatccacccg
acgcccccggccggcgacggcgggagcggctcccggccgcagcggctgctgtggcaaacg
gcggtgcggcacatcaccgagcagcgcttcgttcacgggcaccggggcagcggcggcggg
agcggaagctccagcaaagcctcggaccctgtaggcggcggccccaaccaccacgcgtcg
cagctggccggcgactcggcgcttcccctctacgcgctgggccccggggagagagcgcac
agccccggctgcaccaaagtcttcccggagcgcagcggcagcggcggcggcggcggcagc
gggggcgcgggcgacctgggcttcctgcacctcgactgcgccccgagcaactcggatttc
ttcctcaaggggggctatagctaccgaggggtcattttccccaccctgcgcaactccttc
aagtcccgggatctggagcgcctctaccagcgctatttcctgggccagaggcgcaaatcg
gaggtggtgatgaacgtgctggacgtgctgaccaaactcaccctcttggttctccacttg
agcctggcctcggcccccatggacccgctcaagggcatcctgctgggcttcttcacgggc
atagaggtggtgatctgcgccttggtggtggtcaggaaggacaccacctcgcacacctac
ctgcagtacagcggcgtggtcacctgggtggccatgaccacccagatcttagcagcaggt
ctgggctatgggctcctgggagacagcattggctacgtgctcttcacactcttcgccacc
tacagcatgctgccgctgccgctcacctgggccatcctggctggcctgggcacgtcgtta
ctgcaggtggtcctccaaggggtcatccccaggctggcggtcatttccatcaaccaggtt
gtggcccaggcagtgttattcatgtgtatgaacacggctggaatctttatcagttacctg
tcagaccgggcccagcgccaagccttcctggagacacggaggtgtgtggaagccaggctg
cgcctagagacggaaaaccaaagacaggagcggcttgtgctgtctgtgctcccccggttt
gtcgtcctggagatgatcaatgacatgaccaacgtggaagacgagcacctgcagcatcaa
ttccaccggatctacatccaccgctacgagaatgtcagtattctttttgcagatgtcaaa
ggatttaccaacctctccacgaccttgtccgcccaggagctggtcaggatgctcaatgag
ctctttgctagatttgatcgactggcccacgagcatcactgccttcgcattaaaatcctg
ggagactgctactactgcgtttcgggacttcctgagccccgccaggaccacgcccactgc
tgcgttgaaatgggcctcagcatgatcaaaaccatcaggtatgtgcggtcaaggacgaag
catgatgttgacatgcggattggaatccactcgggctcagtgctatgtggcgtgttgggt
ctacggaagtggcagtttgatgtctggtcttgggatgtggatattgcaaacaaacttgaa
tctggaggaatccctgggaggattcacatttccaaagccacgctggactgcctcaacggt
gactataatgtggaagagggtcatggtaaagagaggaacgaattcttgaggaagcataat
atagagacctatttaattaagcagcctgaggagagtctgctgtctttgcctgaggacatc
gtcaaggaatctgtgagctcctcagacaggagaaacagtggggcgacattcacagaagga
tcctggagccccgaactgccctttgataacatagtggggaaacagaacactctggctgcc
ctaacaagaaattcaataaatctacttccaaaccatcttgcacaagctttgcatgtccag
tctgggcctgaggaaattaacaagagaatagaacataccatcgacttgcggagtggcgat
aaattgagaagagagcatatcaagccattctcactgatgtttaaagactccagcctggag
cacaagtattctcaaatgagggacgaagtattcaaatcaaacctggtctgtgcgtttatc
gttcttctatttatcacggcaatacaaagtttgcttccttcttcaagggtgatgccaatg
gccatccagttttccatcctgattatgctgcactcggctttgatcctcatcaccacagca
gaggattataagtgtttgcccctggtcctccggaaaacttgctgttggattaacgagacc
tatttggccaggaatgtcatcatctttgcgtccatcttgattaatttcctgggcgccatc
ctaaatatcctgtggtgtgattttgacaagtcgatacccttgaagaacctgactttcaat
tcctcagctgtgtttacagatatctgctcctacccagagtacttcgtcttcacgggggtg
ttggccatggtgacctgtgcggttttcctccgacttaactctgtcctgaagctggctgtg
ctgctgattatgattgccatctatgccctgctgaccgagaccatctatgcaggactcttt
ctgcgctatgacaacctgaatcacagtggagaagatttcctggggaccaaggaggcgtca
ctgctgctgatggccatgttcctcctcgctgtcttctaccatggacagcagctggagtac
acagcccgcctggacttcctctggcgagttcaggccaaagaggagatcaacgagatgaag
gagctgagggaacacaatgagaacatgctccggaacatcctgcccagtcacgtggcccgc
cacttcctggagaaggaccgcgacaatgaggagctgtattctcaatcctatgatgccgtt
ggggtgatgtttgcctccatcccagggtttgcagacttctactctcagactgaaatgaac
aaccaaggagtggaatgcctacgcctgctgaatgagatcattgccgacttcgatgagctg
cttggtgaagaccggtttcaagacattgaaaagattaagaccattggcagcacctacatg
gccgtgtcaggcctgtcacctgaaaaacagcaatgtgaagataagtgggaacatctgtgt
gccctggccgacttctctctcgccctgaccgaaagcatacaggagatcaacaagcattct
ttcaacaattttgagctccggattggcatcagtcacggctcagtggtagctggcgttatc
ggcgctaagaaaccacagtatgacatttggggcaaaaccgtgaacctggcaagtcgaatg
gacagcacgggagtcagcggcagaatccaggtcccagaggagacctatctcatcctgaag
gaccagggctttgcctttgactaccgaggggagatctatgtgaagggcatcagtgaacag
gaaggaaaaatcaaaacgtactttctcctgggaagagtccaacccaacccattcatcctg
ccgccgagaaggctgcccgggcagtactccttggccgcggtcgtcctgggcctcgtccag
tccctcaacaggcaaaggcagaagcagctgctgaatgagaacaacaacacgggcatcatc
aagggccattacaaccggcggactttgctgacacccagtgggcctgagccgggagcccca
gccgaaggcaccgacaagtccgagttgccataa

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (51)   
   KEGG PATHWAY (51)   
Chemical substance (5)   
   KEGG COMPOUND (5)   
Chemical reaction (3)   
   KEGG ENZYME (1)   
   KEGG REACTION (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (21)   
   KEGG ORTHOLOGY (1)   
   RefGene (17)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   OC (1)   
Protein sequence (3)   
   RefSeq(pep) (3)   
DNA sequence (3)   
   RefSeq(nuc) (3)   
Protein domain (4)   
   Pfam (4)   
All databases (93)   

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