KEGG   Odobenus rosmarus divergens (Pacific walrus): 101364103
Entry
101364103         CDS       T05148                                 
Symbol
CHUK
Name
(RefSeq) inhibitor of nuclear factor kappa-B kinase subunit alpha
  KO
K04467  inhibitor of nuclear factor kappa-B kinase subunit alpha [EC:2.7.11.10]
Organism
oro  Odobenus rosmarus divergens (Pacific walrus)
Pathway
oro01523  Antifolate resistance
oro04010  MAPK signaling pathway
oro04014  Ras signaling pathway
oro04062  Chemokine signaling pathway
oro04064  NF-kappa B signaling pathway
oro04068  FoxO signaling pathway
oro04150  mTOR signaling pathway
oro04151  PI3K-Akt signaling pathway
oro04210  Apoptosis
oro04380  Osteoclast differentiation
oro04620  Toll-like receptor signaling pathway
oro04621  NOD-like receptor signaling pathway
oro04622  RIG-I-like receptor signaling pathway
oro04623  Cytosolic DNA-sensing pathway
oro04625  C-type lectin receptor signaling pathway
oro04657  IL-17 signaling pathway
oro04658  Th1 and Th2 cell differentiation
oro04659  Th17 cell differentiation
oro04660  T cell receptor signaling pathway
oro04662  B cell receptor signaling pathway
oro04668  TNF signaling pathway
oro04920  Adipocytokine signaling pathway
oro04936  Alcoholic liver disease
oro05010  Alzheimer disease
oro05132  Salmonella infection
oro05135  Yersinia infection
oro05142  Chagas disease
oro05145  Toxoplasmosis
oro05160  Hepatitis C
oro05161  Hepatitis B
oro05162  Measles
oro05163  Human cytomegalovirus infection
oro05164  Influenza A
oro05165  Human papillomavirus infection
oro05166  Human T-cell leukemia virus 1 infection
oro05167  Kaposi sarcoma-associated herpesvirus infection
oro05168  Herpes simplex virus 1 infection
oro05169  Epstein-Barr virus infection
oro05170  Human immunodeficiency virus 1 infection
oro05171  Coronavirus disease - COVID-19
oro05200  Pathways in cancer
oro05208  Chemical carcinogenesis - reactive oxygen species
oro05212  Pancreatic cancer
oro05215  Prostate cancer
oro05220  Chronic myeloid leukemia
oro05221  Acute myeloid leukemia
oro05222  Small cell lung cancer
oro05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
oro05417  Lipid and atherosclerosis
oro05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:oro00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    101364103 (CHUK)
   04014 Ras signaling pathway
    101364103 (CHUK)
   04064 NF-kappa B signaling pathway
    101364103 (CHUK)
   04668 TNF signaling pathway
    101364103 (CHUK)
   04068 FoxO signaling pathway
    101364103 (CHUK)
   04151 PI3K-Akt signaling pathway
    101364103 (CHUK)
   04150 mTOR signaling pathway
    101364103 (CHUK)
 09140 Cellular Processes
  09143 Cell growth and death
   04210 Apoptosis
    101364103 (CHUK)
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    101364103 (CHUK)
   04621 NOD-like receptor signaling pathway
    101364103 (CHUK)
   04622 RIG-I-like receptor signaling pathway
    101364103 (CHUK)
   04623 Cytosolic DNA-sensing pathway
    101364103 (CHUK)
   04625 C-type lectin receptor signaling pathway
    101364103 (CHUK)
   04660 T cell receptor signaling pathway
    101364103 (CHUK)
   04658 Th1 and Th2 cell differentiation
    101364103 (CHUK)
   04659 Th17 cell differentiation
    101364103 (CHUK)
   04657 IL-17 signaling pathway
    101364103 (CHUK)
   04662 B cell receptor signaling pathway
    101364103 (CHUK)
   04062 Chemokine signaling pathway
    101364103 (CHUK)
  09152 Endocrine system
   04920 Adipocytokine signaling pathway
    101364103 (CHUK)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    101364103 (CHUK)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    101364103 (CHUK)
   05208 Chemical carcinogenesis - reactive oxygen species
    101364103 (CHUK)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    101364103 (CHUK)
  09162 Cancer: specific types
   05212 Pancreatic cancer
    101364103 (CHUK)
   05221 Acute myeloid leukemia
    101364103 (CHUK)
   05220 Chronic myeloid leukemia
    101364103 (CHUK)
   05215 Prostate cancer
    101364103 (CHUK)
   05222 Small cell lung cancer
    101364103 (CHUK)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    101364103 (CHUK)
   05170 Human immunodeficiency virus 1 infection
    101364103 (CHUK)
   05161 Hepatitis B
    101364103 (CHUK)
   05160 Hepatitis C
    101364103 (CHUK)
   05171 Coronavirus disease - COVID-19
    101364103 (CHUK)
   05164 Influenza A
    101364103 (CHUK)
   05162 Measles
    101364103 (CHUK)
   05168 Herpes simplex virus 1 infection
    101364103 (CHUK)
   05163 Human cytomegalovirus infection
    101364103 (CHUK)
   05167 Kaposi sarcoma-associated herpesvirus infection
    101364103 (CHUK)
   05169 Epstein-Barr virus infection
    101364103 (CHUK)
   05165 Human papillomavirus infection
    101364103 (CHUK)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    101364103 (CHUK)
   05135 Yersinia infection
    101364103 (CHUK)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    101364103 (CHUK)
   05142 Chagas disease
    101364103 (CHUK)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    101364103 (CHUK)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    101364103 (CHUK)
   05418 Fluid shear stress and atherosclerosis
    101364103 (CHUK)
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    101364103 (CHUK)
  09176 Drug resistance: antineoplastic
   01523 Antifolate resistance
    101364103 (CHUK)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:oro01001]
    101364103 (CHUK)
Enzymes [BR:oro01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.10  IkappaB kinase
     101364103 (CHUK)
Protein kinases [BR:oro01001]
 Serine/threonine kinases: Other
  IKK family [OT]
   101364103 (CHUK)
SSDB
Motif
Pfam: IKBKB_SDD Pkinase PK_Tyr_Ser-Thr IKKbetaNEMObind Pkinase_fungal Kdo TBK1_ULD
Other DBs
NCBI-GeneID: 101364103
NCBI-ProteinID: XP_004401967
UniProt: A0A2U3W208
Position
Unknown
AA seq 745 aa
MERPPGLRPGAGGPWEMRERLGTGGFGNVCLYQHRELDVKIAIKSCRLELSTKNRERWCH
EIQIMKKLNHANVVKACDVPEELNFLINDVPLLAMEYCSGGDLRKLLNKPENCCGLKESQ
ILSLLNDIGSGIRYLHENKIIHRDLKPENIVLQDVGGKIMHKIIDLGYAKDVDQGSLCTS
FVGTLQYLAPELFENKPYTATVDYWSFGTMVFECIAGYRPFLHHLQPFTWHEKIKKKDPK
CIFACEEMTGEVRFSSHLPQPNSLCSLIVEPMENWLQLMLNWDPQQRGGPVDLTLKQPRC
FVLMDHILNLKIVHILNMTSAKIISFLLPPDESLHSLQSRIERETGINTGSQELLSETGI
SLDPRKPASQCVLDGVRGCDSYMVYLFDKSKTVYEGPFASRSLSDCVNYIVRDSKIQLPI
IQLRKVWAEAVHYVSGLKEDYSRLFQGQRAAMLSLLRYNANLTKMKNTLISASQQLKAKL
EFFHKSIQLDLERYSEQMTYGISSEKMLKAWKEMEEKAIHYAEVGVIGYLEDQIMSLHTE
IMELQKSPYGRRQADLMESLEQRAIDLYKQLKHRPSDHFYSDSTEMVKIIVHTVQSQDRV
LKELFGHLSKLLGCKQKIIDLLPKVEMALSNIKEADNTVMFMQGKRQKEIWHLLKIACTQ
SSARSLVVSSLEGAVTPQASAWLPPTSTEREHPLSCVVTPQDGETIAQMIEENLNCLGHL
STIIHEANEEQGSSMMNLDWRWLTE
NT seq 2238 nt   +upstreamnt  +downstreamnt
atggagcggcccccggggctgcggccgggcgcgggcgggccctgggagatgcgggagcgg
ctgggcaccggcggctttgggaacgtctgcctgtatcagcatcgggaacttgatgtcaaa
atagcaattaagtcatgtcgcctagaactaagtaccaaaaacagagaacggtggtgccat
gaaatccagatcatgaagaagttgaaccacgccaacgttgtgaaggcctgtgatgtacct
gaggaactgaattttttaattaatgatgtgcctcttctagcaatggaatactgttctgga
ggagatctccgaaagttactcaacaaaccagaaaattgctgtggacttaaagaaagccag
atactttctttactgaatgatatagggtctggcatccgatatttgcatgaaaacaaaatt
atacatcgtgatctaaaacctgaaaacatagttcttcaggatgttggtggaaagattatg
cataaaataattgatctgggatatgccaaagatgtcgatcaaggaagtctgtgtacatct
tttgtgggaacactgcagtatctggccccagaactctttgagaataaaccttacacagct
actgttgattattggagttttgggaccatggtatttgaatgtattgctggatataggcct
tttttgcatcatctgcagccatttacctggcatgagaagattaagaagaaggatccaaag
tgtatatttgcatgtgaagagatgacaggagaagttcggtttagtagccatttacctcaa
ccaaatagcctttgtagtttaatagtagaacccatggaaaactggcttcagttgatgctg
aattgggatcctcagcaaagaggaggacctgttgatcttactttgaagcagccaagatgt
tttgtattaatggatcacattctgaatttgaagatagtacacatcctaaatatgacttct
gcaaagataatttcttttttgttaccacctgatgaaagtcttcattcactacagtctcgt
attgagcgtgaaactggaataaatactggttctcaagagcttctttcagagacaggaatt
tctctggatcctcggaaaccagcctctcaatgtgttctagatggagtcagaggctgtgat
agctatatggtgtatttgtttgataaaagtaagactgtatatgaaggaccatttgcttcc
agaagtttatctgactgtgtaaattatattgtacgggacagcaaaatacagcttccaatt
atacagttgcgtaaagtatgggctgaagcagtacactatgtgtctgggctaaaagaagac
tacagcaggctgtttcagggacaaagagcagccatgttaagtcttcttagatacaatgct
aacttgacaaaaatgaagaacactttgatctcagcatctcagcaactgaaagctaaattg
gagtttttccacaaaagcattcagcttgacttggaaagatacagtgagcagatgacttat
gggatatcttcagaaaaaatgttaaaagcatggaaggaaatggaagaaaaggctatccac
tatgctgaggtgggtgtcattggttacctagaggatcagatcatgtccctgcacactgaa
atcatggagctgcagaagagcccttatggaagacgtcaggcagacttaatggaatctctg
gaacagcgtgccattgatctgtataagcagttaaagcacagaccttcagatcacttctac
agcgacagcacggaaatggtgaagatcattgtacatactgttcagagtcaggaccgggtt
ctcaaggagctgtttggtcatctgagcaagttattgggctgtaagcagaagattattgat
ctactgcccaaggtggaaatggccctcagtaacatcaaagaagctgacaatactgtcatg
tttatgcagggaaagagacagaaagaaatatggcatctccttaaaattgcctgtacacag
agttctgcccggtccctcgtagtatccagtctagaaggtgcagtaacccctcaggcatca
gcatggcttcccccaacttcaacagaacgtgaacatcctctgtcatgcgtggtaactcct
caagatggggagactatagcacaaatgatagaagaaaatttgaactgtcttggccattta
agcactattattcatgaagcaaatgaggaacagggcagtagtatgatgaatcttgattgg
agatggttaacagaatga

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (50)   
   KEGG PATHWAY (50)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (7)   
   KEGG ORTHOLOGY (1)   
   RefGene (3)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   OC (1)   
Protein sequence (2)   
   UniProt (1)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   RefSeq(nuc) (1)   
Protein domain (7)   
   Pfam (7)   
All databases (72)   

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