KEGG   Odobenus rosmarus divergens (Pacific walrus): 101378635
Entry
101378635         CDS       T05148                                 
Symbol
NF1
Name
(RefSeq) neurofibromin isoform X1
  KO
K08052  neurofibromin 1
Organism
oro  Odobenus rosmarus divergens (Pacific walrus)
Pathway
oro01521  EGFR tyrosine kinase inhibitor resistance
oro04010  MAPK signaling pathway
oro04014  Ras signaling pathway
Brite
KEGG Orthology (KO) [BR:oro00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    101378635 (NF1)
   04014 Ras signaling pathway
    101378635 (NF1)
 09160 Human Diseases
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    101378635 (NF1)
SSDB
Motif
Pfam: RasGAP CRAL_TRIO_2 CRAL_TRIO MIF4G_like_2
Other DBs
NCBI-GeneID: 101378635
NCBI-ProteinID: XP_004399683
UniProt: A0A2U3VW36
Position
Unknown
AA seq 2841 aa
MAAHRPVEWVQAVVSRFDEQLPIKTGQQNTHTKVSTEHNKECLINISKYKFSLVISGLTT
ILKNVNNMRIFGEAAEKNLYLSQLIILDTLEKCLAGQPKDTMRLDETMLVKQLLPEICHF
LHTCREGNQHAAELRNSASGVLFSLSCNNFNAVFSRISTRLQELTVCSEDNVDVHDIELL
QYINVDCAKLKRLLKETAFKFKALKKVAQLAVINSLEKAFWNWVENYPDEFTKLYQIPQT
DMAECAEKLFDLVDGFAESTKRKAAVWPLQIILLILCPEIIQDISKDVVDENNMNKKLFL
DSLRKALAGHGGSRQLTESAAIACVKLCKASTYINWEDNSVIFLLVQSMVVDLKNLLFNP
SKPFSRGSQPADVDLMIDCLVSCFRISPHNNQHFKICLAQNSPSTFHYVLVNSLHRIITN
SALDWWPKIDAVYCHSVELRNMFGETLHKAVQGCGAHPAIRMAPSLTFKEKVTSLKFKEK
PTDLETRSYKYLLLSMVKLIHADPKLLLCNPRKQGPETQGSTAELITGLVQLVPQSHMPE
IAQEAMEALLVLHQLDSIDLWNPDAPVETFWEISSQMLFYICKKLTSHQMLSSTEILKWL
REILICRNKFLLKNKQADRSSCHFLFLYGVGCDVPSSGTTGQMSMNHEELLPSCTPGASL
RKGKGNSSMDSAAGCSGTPPICRQAQTKLEVALYMFLWSPDTEAVLVAMSCFRHLCEEAD
IRCGVDEVSVHNFLPNYNTFMEFASVSNMMSTGRAALQKRVMALLRRIEHPTAGNTEAWE
DTHAKWEQATKLILNYPKAKMEDGQAAESLHKTIVKRRMSHVSGGGSIDLSDTDSLQEWI
NMTGFLCALGGVCLQQRSNSGLATYSPPMGPVSERKGSMISVMSSEGNADTPVSKFMDRL
LSLMVCNHEKVGLQIRTNVKDLVGLELSPALYPMLFNKLKNTISKFFDSQGQVLLTDTNT
QFVEQTIAIMKNLLDNHTEGSSEHLGQASIETMMLNLVRYVRVLGNMVHAIQIKTKLCQL
VEVMMARRDDLSFCQEMKFRNKMVEYLTDWVMGTSNQAADDDVKCLTRDLDQASMEAVVS
LLAGLPLQPEEGDGVELMEAKSQLFLKYFTLFMNLLNDCSEVEDENAQTGGRKRGMSRRL
ASLRHCTVLAMSNLLNANVDSGLMHSIGLGYHKDLQTRATFMEVLTKILQQGTEFDTLAE
TVLADRFERLVELVTMMGDQGELPIAMALANVVPCSQWDELARVLVTLFDSRHLLYQLLW
NMFSKEVELADSMQTLFRGNSLASKIMTFCFKVYGATYLQKLLDPLLRIVITSSDWQHVS
FEVDPTRLEQSESLEENQRNLLQMTEKFFHAIISSSSEFPPQLRSVCHCLYQATCHSLLN
KATVKEKKENKKSVVSQRFPQNSIGAVGSAMFLRFINPAIVSPYEAGILDKKPPPRIERG
LKLMSKILQSIANHVLFTKEEHMRPFNDFVKSNFDAARRFFLDIASDCPTSDAVNHSLSF
ISDGNVLALHRLLWNNQEKIGQYLSSNRDHKAVGRRPFDKMATLLAYLGPPEHKPVADTH
WSSLNLTSSKFEEFMTRHQVHEKEEFKALKTLSIFYQAGTSKAGNPIFYYVARRFKTGQI
NGDLLIYHVLLTLKPYYAKPYEIVVDLTHTGPSNRFKTDFLSKWFVVFPGFAYDNVSAVY
IYNCNSWVREYTKYHERLLTGLKGSKRLIFIDCPGKLAEHIEHEQQKLPAATLALEEDLK
VFHNALKLAHKDTKVSIKVGSTAVQVTSAERTKVLGQSVFLNDIYYASEIEEICLVDENQ
FTLTIANQGTPLTFMHQECEAIVQSIIHIRTRWELSQPDSIPQHTKIRPKDVPGTLLNIA
LLNLGSSDPSLRSAAYNLLCALTCTFNLKIEGQLLETSGLCIPANNTLFIVSISKTLAAN
EPHLTLEFLEECISGFSKSSIELKHLCLEYMTPWLSNLVRFCKHNDDAKRQRVTAILDKL
ITMTINEKQMYPSIQAKIWGSLGQITDLLDVVLDSFIKTSATGGLGSIKAEVMADTAVAL
ASGNVKLVSSKVIGRMCKIIDKTCLSPTPTLEQHLMWDDIAILARYMLMLSFNNSLDVAA
HLPYLFHVVTFLVATGPLSLRASTHGLVINIIHSLCTCSQLHFSEETKQVLRLSLTEFSL
PKFYLLFGISKVKSAAVIAFRSSYRDRSFSPGSYERETFALTSLETVTEALLEIMEACMR
DIPTCKWLDQWTELAQRFAFQYNPSLQPRALVVFGCISKRVSHGQIKQIIRILSKALESC
LKGPDTYNSQVLIEATVIALTKLQPLLNKDSPLHKALFWVAVAVLQLDEVNLYSAGTALL
EQNLHTLDSLRVFNDKSPEEVFMAIRNPLEWHCKQMDHFVGLNFNSNFNFALVGHLLKGY
RHPSPAIVARTVRILHTLLTLVNKHRNCDKFEVNTQSVAYLAALLTVSEEVRSRCSLKHR
KSLLLTDISMENVPMDTYPIHHGDPSYRTLKENQPWSSPKGSEGYLAATYPTVGQTSPRA
RKSMSLDMGQPSQANTKKLLGTRKSFDHLISDTKAPKRQEMESGITTPPKMRRVAETDYE
METQRISSSQQHPHLRKVSVSESNVLLDEEVLTDPKIQALLLTVLATLVKYTTDEFDQRI
LYEYLAEASVVFPKVFPVVHNLLDSKINTLLSLCQDPNLLNPIHGIVQSVVYHEESPPQY
QTSYLQSFGFNGLWRFAGPFSKQTQIPDYAELIVKFLDALIDTYLPGIDEETSEESLLTP
TSPYPPAVQSQLSITANLNLSNSMTSLATSQHSPGIDKENVELSPTTGHCNSGRTRHGSA
SQVQKQRSAGSFKRNSIKKIV
NT seq 8526 nt   +upstreamnt  +downstreamnt
atggccgcgcacaggccggtggaatgggtccaggccgtggtcagccgcttcgacgagcag
cttccaataaaaacaggacagcagaacacacataccaaagtcagtaccgaacacaacaag
gaatgtcttattaatatttccaaatacaagttttctttggttatcagcggcctcaccact
atcttaaagaatgttaacaatatgagaatatttggagaagctgctgaaaaaaatttatat
ctctctcagttgattatattggatacactggaaaaatgtcttgctgggcaaccaaaggac
acaatgagattagatgaaacaatgctggtcaaacagttgctcccagaaatctgccatttt
cttcatacctgtcgggaaggaaaccaacatgccgctgaacttcggaattctgcctctggt
gttttattttctctcagctgcaacaacttcaatgcagtgtttagtcggatttctaccagg
ttacaggaattgactgtttgttcagaagacaatgttgatgttcatgatatagaattgtta
cagtatatcaatgtggattgtgcaaaattaaaacgactcctaaaggaaactgcatttaaa
tttaaagccctaaagaaggttgcacagttagcagttataaatagcctggaaaaagcattt
tggaactgggtagaaaattatccagatgaatttacaaagctataccagattccacagact
gatatggctgagtgtgcagaaaaactgtttgacttggtggatggttttgctgaaagcacc
aaacgtaaagcagcggtttggccactacaaatcattctccttatcttgtgtccagaaata
atccaggatatctccaaggatgtggttgatgaaaacaacatgaataagaagttgtttttg
gacagtctacgaaaagcacttgccggccacggaggaagcaggcagctgacggaaagtgcc
gcaattgcctgtgtcaaactgtgtaaagcaagtacttacatcaactgggaagataactct
gtcattttcctactagttcagtccatggtggtagatcttaagaacctgctttttaatcca
agtaaaccattctcaagaggcagtcagcctgcagatgtggatctaatgattgactgcctt
gtttcttgctttcgtataagcccccacaacaaccaacactttaagatctgcctggctcag
aattccccttctacatttcactatgtgctggtaaattcactccatcgaatcatcaccaat
tctgcattggattggtggcctaagattgatgctgtatactgtcactcagttgagcttcga
aacatgtttggtgaaacccttcataaagcagtgcagggctgtggagcacacccagcaata
cggatggcaccgagtcttacatttaaagaaaaagtaacaagccttaaatttaaagaaaaa
cctacagacctggagacaagaagctataagtatcttctcttgtccatggtgaaactaatt
catgcagatccaaagctcttgctttgtaatccaagaaaacaggggcctgaaacccaaggc
agtacagcggagttaataacagggctcgtccagctggtccctcagtcacacatgccagag
attgctcaggaagcaatggaggctctgctggttcttcatcagttagatagcattgatttg
tggaatcctgatgctcctgtagaaacattctgggaaattagctctcaaatgcttttttac
atctgcaagaaattaactagccatcaaatgcttagtagcacagaaattctcaaatggttg
cgggaaattttgatctgcaggaataaatttcttcttaaaaataagcaggcagatagaagt
tcctgtcactttctcttcctttatggggtaggatgtgatgttccttcaagtggaactacc
ggtcagatgtccatgaatcatgaagaattactaccttcttgtactcctggagcctctctt
cggaagggaaaaggaaactcatccatggatagtgcagcagggtgcagtggcaccccgccg
atctgccgacaagctcagactaaactagaagtggccctgtatatgttcctgtggagccct
gacactgaagctgttctggtggccatgtcctgtttccgccacctctgcgaggaagcagat
atccggtgtggggtggacgaggtgtcagtgcacaacttcttgcccaactataacacattt
atggaatttgcctctgtcagcaatatgatgtcaacaggaagagcagcacttcagaaaaga
gtgatggcactactaaggcgcattgagcatcccactgcaggaaacaccgaggcttgggaa
gatacacatgcaaagtgggaacaagctacaaaactaatcctcaactacccgaaagctaaa
atggaagatggccaggctgctgaaagccttcacaagaccattgttaagaggcgaatgtct
catgtgagtggaggaggatccatagatttgtctgacacggactccctacaggaatggatc
aacatgactggcttcctttgtgcccttgggggagtgtgcctacagcagagaagcaattct
ggcctggcaacctatagcccacccatgggcccagtcagtgaacgcaagggttccatgatt
tcagtgatgtcttcagagggaaatgcagatacacctgtcagcaaatttatggatcggctg
ttatccttaatggtgtgtaaccatgagaaagtgggacttcaaatacggaccaatgttaag
gatctggtgggtcttgaattgagtcctgctctttatccaatgctgtttaacaaattaaag
aataccatcagcaagttttttgactcccaaggacaggttttattgactgacaccaatact
caatttgtggagcaaaccatagctataatgaagaacttactagataatcatactgaaggc
agctcggaacatctggggcaagctagcattgaaacaatgatgttaaatctagtcagatat
gttcgtgtgcttgggaatatggtccatgcaattcaaataaaaacgaaactgtgtcagtta
gtcgaggtaatgatggcaaggagagatgacctctcattttgtcaagagatgaaatttagg
aataagatggtagaatacctgacagactgggtgatgggaacatcaaaccaagcagcagat
gatgatgtaaaatgtcttacaagagacttggaccaggcgagcatggaagcggtagtttca
ctcctggctggtcttccgctgcagccggaggaaggagatggtgtggaattgatggaagcc
aaatcacagttatttcttaagtatttcacattgttcatgaaccttttgaatgactgtagt
gaagttgaagatgaaaatgcacaaacaggtggcaggaagcgtggcatgtctcggaggctg
gcgtcactgaggcactgtacggtcctcgcaatgtcaaacttactgaatgctaatgtggac
agtggcctcatgcactccataggtttaggttatcacaaagatcttcagacaagagctaca
tttatggaagttctgacaaaaatcctccagcaaggcacagaatttgacacacttgcagaa
acggtgctggccgaccggtttgagaggctggtagaattggtcacgatgatgggagaccag
ggggagctcccgatagccatggcgctggccaacgtggtcccgtgttctcagtgggatgag
ctagctcgagttctagtgactctgtttgattctcggcatttactctaccaactgctctgg
aacatgttttctaaggaagtggaattggcagactccatgcagactcttttccgaggaaac
agcttagccagtaaaataatgaccttctgtttcaaggtatatggtgctacctacctacaa
aaactcctggatccgttattacgaattgtgatcacatcctctgattggcagcatgttagc
tttgaagtggatcctaccaggttggagcagtcagagagtcttgaggaaaaccaacggaac
cttcttcagatgactgaaaagttcttccatgccatcatcagttcctcctcagaattcccc
cctcagcttagaagtgtgtgccactgtttataccaggcaacttgccactccctactgaat
aaagctacagtaaaagaaaaaaaggaaaacaaaaaatcagtggttagccagcgattccct
cagaacagcatcggtgcagtgggaagtgccatgttcctcagatttatcaatcctgccatt
gtctcaccctatgaagcagggattttagataaaaagccaccacctagaatcgaaaggggc
ttgaagttaatgtcaaagatacttcagagtattgccaatcatgttcttttcacaaaagaa
gagcatatgcggccttttaatgattttgtgaaaagcaactttgatgcagcacggaggttt
ttccttgatatagcatctgattgtcctacaagtgatgcagtaaatcatagtctttccttc
atcagtgatggcaatgtgcttgctttacatcgtctactctggaacaatcaagagaaaatt
ggccagtatctttctagcaacagggatcacaaagctgttggaagacgacctttcgataag
atggcaacacttcttgcgtacctgggtcctccagagcacaaacctgtggcagatacacac
tggtccagccttaaccttaccagttcaaagtttgaggaatttatgactaggcatcaagta
catgaaaaagaagaattcaaggctttgaaaacattaagcattttctaccaagctgggact
tccaaagctgggaatcctatattttattatgttgcacggaggtttaaaactggtcaaatc
aatggtgatttgctgatataccacgtcttgctgactttaaagccatattatgcaaagcca
tatgaaattgtagtggaccttacccatactgggcctagcaatcgctttaaaacggacttt
ctctccaagtggtttgttgtttttcctggctttgcttatgacaatgtctctgcagtctat
atctacaactgtaactcctgggtcagggagtacaccaagtatcacgagcggctgctgact
ggcctcaaaggcagcaaaaggctcatcttcatagactgtcctgggaaactggctgagcac
atagagcatgaacagcagaaactgcctgctgccacactggctttagaagaggacttgaag
gtattccacaacgctctcaagctagctcacaaagacaccaaggtttctattaaagttggt
tctactgctgtccaggtaacctcagcagagcgaacaaaagtcttggggcaatcagtcttt
ctaaatgatatctattatgcttcggaaattgaagagatctgcctggtggatgagaaccag
ttcaccttaaccattgcaaaccagggcacaccactcaccttcatgcaccaggagtgcgaa
gccattgtccagtctatcattcatattcggacacgctgggagctgtcgcagcctgactcc
atcccccagcacaccaagattcggccaaaagatgtccctgggacgctgctcaatattgca
ttacttaatttaggcagttcagaccctagtttacggtcagccgcctataatcttctgtgt
gccttaacttgtacctttaatttaaaaatcgagggccagttactagagacatcaggttta
tgcatccctgccaacaacaccctctttattgtctctattagtaagacactggcagccaat
gagccacatctcaccttagaatttttggaagagtgtatttctggatttagcaaatctagt
attgaattgaaacacctttgtttggaatacatgactccatggctgtcaaatctagtccgt
ttttgtaaacacaatgatgatgccaaacgacaaagagttactgctattcttgataagctg
ataacaatgaccataaatgaaaaacagatgtacccatctatccaagccaaaatatggggg
agccttgggcagattacagatctccttgatgttgtactagacagtttcatcaaaaccagt
gcaacaggtggcctgggatcaataaaagctgaggtgatggcagatactgctgtagctttg
gcttctggaaatgtgaaattggtttcaagcaaggttattggaaggatgtgcaaaataatt
gacaagacatgcttatctccaactcctaccttagaacaacatcttatgtgggacgatatt
gctattctagcacgctacatgctgatgctgtccttcaacaattcccttgacgtggcagct
catctcccctacctcttccatgttgttaccttcttagtagccacagggccgctctccctt
agagcttccacacatggattggtcattaatatcattcactctctgtgtacttgttcacag
cttcattttagtgaagagaccaagcaagttttgagactcagtttgacggagttctcatta
cccaagttttacctgctgtttggcattagcaaagtcaagtcagctgccgtcattgccttc
cgctctagttaccgggacaggtcattctctcccggctcctatgaaagggagacttttgct
ttgacttccctggaaacagtcacagaagctttgttggagatcatggaggcatgtatgaga
gatattccaacatgcaagtggctggaccagtggacagaactagctcaaagatttgcattc
caatataatccatcgctgcaaccaagagctcttgttgtctttggctgtattagcaaacgt
gtgtctcatgggcagataaagcagattatccgtattcttagcaaggcacttgagagttgc
ttaaaaggacctgatacttacaacagtcaagttctgatagaagccacagtaatagcacta
accaagttacaaccacttcttaataaggactcccctctgcacaaagccctcttttgggtc
gctgtggctgtgctacagctcgacgaggtcaacttgtattcagcaggcaccgcacttctg
gaacagaacctgcacaccttagacagtctgcgggtattcaacgacaagagtccagaggaa
gtatttatggcaatccggaatcctcttgaatggcactgcaagcaaatggatcattttgtt
ggactcaatttcaactctaactttaacttcgcactggttggacacctcttaaaagggtac
agacatccttcacctgccattgttgcaagaacagtcagaattttgcatacactactaact
ctggttaacaaacatagaaactgtgataaatttgaggtgaacacacagagcgtggcttac
ttagcagccttactcacagtgtctgaggaggttcgaagtcgctgtagcctaaaacataga
aagtctcttcttcttactgatatttcaatggaaaatgttcctatggatacatatcccatt
catcatggcgaccctagctataggacactaaaggagaaccagccgtggtcatctcccaaa
ggttctgaagggtaccttgcagccacctatccaactgtgggccagaccagtccccgagcc
aggaaatccatgagtctggacatggggcagccttctcaggccaatacgaagaagttgctg
ggaacaaggaaaagttttgatcacttgatatcagacacaaaggctcctaaaaggcaagaa
atggaatcagggatcacaacaccccccaaaatgaggagagtagcagaaactgattatgaa
atggaaactcagaggatttcctcatcacaacaacacccgcatttacgcaaagtttcagtg
tctgaatcaaatgttctcttggatgaagaagtacttactgatccgaagatccaagcactt
cttcttactgttctggctacgctggtaaaatacaccacagatgagtttgatcagcgaatt
ctttatgagtacttagcagaagccagtgttgttttccccaaggtttttcctgtcgtgcac
aatttgttggactctaagatcaataccctgttgtcattgtgccaagatccaaatttgtta
aatccaattcatggaatcgtgcagagtgtggtgtaccatgaagaatccccaccacagtac
caaacatcttacctacaaagttttggttttaatggcttgtggcggtttgcaggacccttt
tcaaagcaaacacaaatcccagactatgctgagcttattgttaagtttcttgatgccttg
attgacacgtatttgcctggaattgatgaagaaaccagtgaggagtccctcctgacaccc
acttctccttatcctcctgcagtgcagagccagcttagtattactgctaaccttaacctt
tctaattccatgacctcacttgcaacttcccagcattccccaggaatcgacaaggagaac
gttgaactctcccccaccaccgggcactgtaacagtggacgaactcgccatggatccgca
agccaagtgcagaagcaaagaagcgctggcagtttcaaacgtaatagcattaagaagatc
gtgtga

  All links  
Ontology (1)   
   KEGG BRITE (1)   
Pathway (3)   
   KEGG PATHWAY (3)   
Genome (1)   
   KEGG GENOME (1)   
Gene (14)   
   KEGG ORTHOLOGY (1)   
   RefGene (10)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   OC (1)   
Protein sequence (3)   
   UniProt (1)   
   RefSeq(pep) (2)   
DNA sequence (2)   
   RefSeq(nuc) (2)   
Protein domain (4)   
   Pfam (4)   
All databases (28)   

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