KEGG   PATHWAY: pae00740
Entry
pae00740                    Pathway                                

Name
Riboflavin metabolism - Pseudomonas aeruginosa PAO1
Class
Metabolism; Metabolism of cofactors and vitamins
Pathway map
pae00740  Riboflavin metabolism
pae00740

Module
pae_M00125  Riboflavin biosynthesis, plants and bacteria, GTP => riboflavin/FMN/FAD [PATH:pae00740]
Other DBs
GO: 0006771
Organism
Pseudomonas aeruginosa PAO1 [GN:pae]
Gene
PA4047  ribA; GTP cyclohydrolase II [KO:K01497] [EC:3.5.4.25]
PA4054  ribB; 3,4-dihydroxy-2-butanone-4-phosphate synthase [KO:K14652] [EC:4.1.99.12 3.5.4.25]
PA4056  ribD; riboflavin-specific deaminase/reductase [KO:K11752] [EC:3.5.4.26 1.1.1.193]
PA5281  hydrolase [KO:K20862] [EC:3.1.3.102 3.1.3.104]
PA4053  ribE; 6,7-dimethyl-8-ribityllumazine synthase [KO:K00794] [EC:2.5.1.78]
PA4055  ribC; riboflavin synthase subunit alpha [KO:K00793] [EC:2.5.1.9]
PA4561  ribF; bifunctional riboflavin kinase/FMN adenylyltransferase [KO:K11753] [EC:2.7.1.26 2.7.7.2]
PA0190  acid phosphatase [KO:K09474] [EC:3.1.3.2]
PA4092  hpaC; 4-hydroxyphenylacetate 3-monooxygenase small subunit [KO:K00484] [EC:1.5.1.36]
PA2357  msuE; FMN reductase MsuE [KO:K00299] [EC:1.5.1.38]
PA3446  NAD(P)H-dependent FMN reductase [KO:K00299] [EC:1.5.1.38]
PA1274  5,6-dimethylbenzimidazole synthase [KO:K04719] [EC:1.13.11.79]
Compound
C00016  FAD
C00044  GTP
C00061  FMN
C00199  D-Ribulose 5-phosphate
C00255  Riboflavin
C00474  Ribitol
C01007  Reduced riboflavin
C01268  5-Amino-6-(5'-phosphoribosylamino)uracil
C01304  2,5-Diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one
C01352  FADH2
C01727  Lumichrome
C01847  Reduced FMN
C03114  Dimethylbenzimidazole
C04332  6,7-Dimethyl-8-(D-ribityl)lumazine
C04454  5-Amino-6-(5'-phospho-D-ribitylamino)uracil
C04732  5-Amino-6-(1-D-ribitylamino)uracil
C05995  7-Hydroxy-6-methyl-8-ribityllumazine
C15556  L-3,4-Dihydroxybutan-2-one 4-phosphate
C15563  2-Amino-5-formylamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one
C18910  2,5-Diamino-6-(5-phospho-D-ribitylamino)pyrimidin-4(3H)-one
Reference
  Authors
Vitreschak AG, Rodionov DA, Mironov AA, Gelfand MS.
  Title
Regulation of riboflavin biosynthesis and transport genes in bacteria by transcriptional and translational attenuation.
  Journal
Nucleic Acids Res 30:3141-51 (2002)
DOI:10.1093/nar/30.14.3141
Reference
  Authors
Fischer M, Haase I, Feicht R, Richter G, Gerhardt S, Changeux JP, Huber R, Bacher A.
  Title
Biosynthesis of riboflavin: 6,7-dimethyl-8-ribityllumazine synthase of Schizosaccharomyces pombe.
  Journal
Eur J Biochem 269:519-26 (2002)
DOI:10.1046/j.0014-2956.2001.02674.x
Reference
  Authors
Haase I, Fischer M, Bacher A, Schramek N.
  Title
Temperature-dependent presteady state kinetics of lumazine synthase from the hyperthermophilic eubacterium Aquifex aeolicus.
  Journal
J Biol Chem 278:37909-15 (2003)
DOI:10.1074/jbc.M303090200
Reference
  Authors
Fischer M, Romisch W, Illarionov B, Eisenreich W, Bacher A.
  Title
Structures and reaction mechanisms of riboflavin synthases of eubacterial and archaeal origin.
  Journal
Biochem Soc Trans 33:780-4 (2005)
DOI:10.1042/BST0330780
Related
pathway
pae00030  Pentose phosphate pathway
pae00040  Pentose and glucuronate interconversions
pae00230  Purine metabolism
pae00860  Porphyrin and chlorophyll metabolism
KO pathway
ko00740   

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