Entry |
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Name |
Glycine, serine and threonine metabolism
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Description |
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD: M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD: M00018].
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Class |
Metabolism; Amino acid metabolism
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Pathway map |
map00260 | Glycine, serine and threonine metabolism |

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Module |
M00018 | Threonine biosynthesis, aspartate => homoserine => threonine [PATH:map00260] |
M00338 | Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:map00260] |
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Disease |
H00191 | Nonketotic hyperglycinemia |
H00834 | Guanidinoacetate methyltransferase deficiency |
H00849 | Cerebral creatine deficiency syndrome |
H01003 | Dimethylglycine dehydrogenase deficiency |
H01079 | 3-Phosphoglycerate dehydrogenase (3-PGDH) deficiency |
H01082 | Phosphoserine aminotransferase deficiency |
H01951 | Glycogen storage disease type X |
H02116 | Phosphoserine phosphatase deficiency |
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Other DBs |
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Reference |
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Authors |
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds). |
Title |
[Cellular Functions and Metabolic Maps] (In Japanese) |
Journal |
Tokyo Kagaku Dojin (1997) |
Reference |
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Authors |
Kuhlmann AU, Bremer E. |
Title |
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp. |
Journal |
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Reference |
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Authors |
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H. |
Title |
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine. |
Journal |
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Reference |
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Authors |
Bursy J, Pierik AJ, Pica N, Bremer E. |
Title |
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase. |
Journal |
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Reference |
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Authors |
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C. |
Title |
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens. |
Journal |
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Reference |
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Authors |
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J |
Title |
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation. |
Journal |
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Reference |
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Authors |
Rees WD, Hay SM |
Title |
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell. |
Journal |
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Reference |
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Authors |
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD |
Title |
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity. |
Journal |
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Reference |
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Authors |
Chen X, Jhee KH, Kruger WD |
Title |
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine. |
Journal |
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Related pathway |
map00250 | Alanine, aspartate and glutamate metabolism |
map00270 | Cysteine and methionine metabolism |
map00290 | Valine, leucine and isoleucine biosynthesis |
map00330 | Arginine and proline metabolism |
map00630 | Glyoxylate and dicarboxylate metabolism |
map00860 | Porphyrin and chlorophyll metabolism |
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KO pathway |
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