KEGG   PATHWAY: map00260
Entry
map00260                    Pathway                                

Name
Glycine, serine and threonine metabolism
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
map00260  Glycine, serine and threonine metabolism
map00260

Module
M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:map00260]
M00020  Serine biosynthesis, glycerate-3P => serine [PATH:map00260]
M00033  Ectoine biosynthesis, aspartate => ectoine [PATH:map00260]
M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:map00260]
M00555  Betaine biosynthesis, choline => betaine [PATH:map00260]
M00919  Ectoine degradation, ectoine => aspartate [PATH:map00260]
Disease
H00117  Primary hyperoxaluria
H00182  Cystathioninuria
H00183  Homocystinuria
H00184  Hypermethioninemia
H00191  Nonketotic hyperglycinemia
H00834  Guanidinoacetate methyltransferase deficiency
H00849  Cerebral creatine deficiency syndrome
H01003  Dimethylglycine dehydrogenase deficiency
H01079  3-Phosphoglycerate dehydrogenase (3-PGDH) deficiency
H01082  Phosphoserine aminotransferase deficiency
H01951  Glycogen storage disease type X
H02116  Phosphoserine phosphatase deficiency
H02117  Neu-Laxova syndrome
H02380  D-glyceric aciduria
Other DBs
GO: 0006544 0006563 0070178 0006566
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
map00010  Glycolysis / Gluconeogenesis
map00020  Citrate cycle (TCA cycle)
map00230  Purine metabolism
map00250  Alanine, aspartate and glutamate metabolism
map00270  Cysteine and methionine metabolism
map00290  Valine, leucine and isoleucine biosynthesis
map00300  Lysine biosynthesis
map00330  Arginine and proline metabolism
map00460  Cyanoamino acid metabolism
map00564  Glycerophospholipid metabolism
map00600  Sphingolipid metabolism
map00620  Pyruvate metabolism
map00630  Glyoxylate and dicarboxylate metabolism
map00640  Propanoate metabolism
map00680  Methane metabolism
map00860  Porphyrin and chlorophyll metabolism
map00920  Sulfur metabolism
KO pathway
ko00260   

  All links  
Pathway (6)   
   KEGG MODULE (6)   
Disease (14)   
   KEGG DISEASE (14)   
Chemical substance (50)   
   KEGG COMPOUND (50)   
Chemical reaction (141)   
   KEGG ENZYME (69)   
   KEGG REACTION (72)   
Gene (644540)   
   KEGG ORTHOLOGY (100)   
   RefGene (644440)   
Literature (8)   
   PubMed (8)   
All databases (644759)   

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