KEGG   PATHWAY: map00600Help
Entry
map00600                    Pathway                                

Name
Sphingolipid metabolism
Class
Metabolism; Lipid metabolism
BRITE hierarchy
Pathway map
map00600  Sphingolipid metabolism
map00600

Ortholog table
Module
M00066  Lactosylceramide biosynthesis [PATH:map00600]
M00067  Sulfoglycolipids biosynthesis, ceramide/1-alkyl-2-acylglycerol => sulfatide/seminolipid [PATH:map00600]
M00094  Ceramide biosynthesis [PATH:map00600]
M00099  Sphingosine biosynthesis [PATH:map00600]
M00100  Sphingosine degradation [PATH:map00600]
Disease
H00125  Fabry disease
H00126  Gaucher disease
H00127  Metachromatic leukodystrophy
H00135  Krabbe disease
H00137  Niemann-Pick disease type A/B
H00138  Farber lipogranulomatosis
H00142  Sialidosis
H00265  Hereditary sensory and autonomic neuropathy
H00276  Galactosialidosis
H00281  GM1 gangliosidosis
H00423  Sphingolipidosis
H00424  Defects in the degradation of sphingomyelin
H00426  Gangliosidosis
Other DBs
GO: 0006665 0030148
Reference
  Authors
Merrill AH Jr.
  Title
De novo sphingolipid biosynthesis: a necessary, but dangerous, pathway.
  Journal
J Biol Chem 277:25843-6 (2002)
DOI:10.1074/jbc.R200009200
Reference
  Authors
Tani M, Okino N, Mitsutake S, Tanigawa T, Izu H, Ito M.
  Title
Purification and characterization of a neutral ceramidase from mouse liver. A single protein catalyzes the reversible reaction in which ceramide is both hydrolyzed and synthesized.
  Journal
J Biol Chem 275:3462-8 (2000)
DOI:10.1074/jbc.275.5.3462
Reference
  Authors
Hannun YA, Luberto C, Argraves KM.
  Title
Enzymes of sphingolipid metabolism: from modular to integrative signaling.
  Journal
Biochemistry 40:4893-903 (2001)
DOI:10.1021/bi002836k
Reference
PMID:1495423
  Authors
Merrill AH Jr, Wang E.
  Title
Enzymes of ceramide biosynthesis.
  Journal
Methods Enzymol 209:427-37 (1992)
DOI:10.1016/0076-6879(92)09053-6
Reference
PMID:8457204
  Authors
Hirschberg K, Rodger J, Futerman AH.
  Title
The long-chain sphingoid base of sphingolipids is acylated at the cytosolic surface of the endoplasmic reticulum in rat liver.
  Journal
Biochem J 290 ( Pt 3):751-7 (1993)
DOI:10.1042/bj2900751
Reference
  Authors
Dickson RC, Lester RL.
  Title
Metabolism and selected functions of sphingolipids in the yeast Saccharomyces cerevisiae.
  Journal
Biochim Biophys Acta 1438:305-21 (1999)
DOI:10.1016/S1388-1981(99)00068-2
KO pathway
ko00600   

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