KEGG   PATHWAY: map00600Help
Entry
map00600                    Pathway                                

Name
Sphingolipid metabolism
Class
Metabolism; Lipid metabolism
BRITE hierarchy
Pathway map
map00600  Sphingolipid metabolism
map00600

Ortholog table
Module
M00066  Lactosylceramide biosynthesis [PATH:map00600]
M00067  Sulfoglycolipids biosynthesis, ceramide/1-alkyl-2-acylglycerol => sulfatide/seminolipid [PATH:map00600]
M00094  Ceramide biosynthesis [PATH:map00600]
M00099  Sphingosine biosynthesis [PATH:map00600]
M00100  Sphingosine degradation [PATH:map00600]
Disease
H00125  Fabry disease
H00126  Gaucher disease
H00127  Metachromatic leukodystrophy (MLD)
H00135  Krabbe disease
H00137  Niemann-Pick disease (NPD), type A/ B
H00138  Farber lipogranulomatosis
H00142  Sialidosis
H00265  Hereditary sensory and autonomic neuropathy (HSAN)
H00276  Galactosialidosis
H00281  GM1 gangliosidosis
H00423  Defects in the degradation of sulfatide
H00424  Defects in the degradation of sphingomyelin
H00426  Defects in the degradation of ganglioside
H00810  Progressive myoclonic epilepsy (PME/ EPM)
Other DBs
GO: 0006665 0030148
Reference
  Authors
Merrill AH Jr.
  Title
De novo sphingolipid biosynthesis: a necessary, but dangerous, pathway.
  Journal
J Biol Chem 277:25843-6 (2002)
DOI:10.1074/jbc.R200009200
Reference
  Authors
Tani M, Okino N, Mitsutake S, Tanigawa T, Izu H, Ito M.
  Title
Purification and characterization of a neutral ceramidase from mouse liver. A single protein catalyzes the reversible reaction in which ceramide is both hydrolyzed and synthesized.
  Journal
J Biol Chem 275:3462-8 (2000)
DOI:10.1074/jbc.275.5.3462
Reference
  Authors
Hannun YA, Luberto C, Argraves KM.
  Title
Enzymes of sphingolipid metabolism: from modular to integrative signaling.
  Journal
Biochemistry 40:4893-903 (2001)
DOI:10.1021/bi002836k
Reference
PMID:1495423
  Authors
Merrill AH Jr, Wang E.
  Title
Enzymes of ceramide biosynthesis.
  Journal
Methods Enzymol 209:427-37 (1992)
DOI:10.1016/0076-6879(92)09053-6
Reference
PMID:8457204
  Authors
Hirschberg K, Rodger J, Futerman AH.
  Title
The long-chain sphingoid base of sphingolipids is acylated at the cytosolic surface of the endoplasmic reticulum in rat liver.
  Journal
Biochem J 290 ( Pt 3):751-7 (1993)
DOI:10.1042/bj2900751
Reference
  Authors
Dickson RC, Lester RL.
  Title
Metabolism and selected functions of sphingolipids in the yeast Saccharomyces cerevisiae.
  Journal
Biochim Biophys Acta 1438:305-21 (1999)
DOI:10.1016/S1388-1981(99)00068-2
KO pathway
ko00600   

DBGET integrated database retrieval system