KEGG   PATHWAY: map00760Help
Entry
map00760                    Pathway                                

Name
Nicotinate and nicotinamide metabolism
Class
Metabolism; Metabolism of cofactors and vitamins
BRITE hierarchy
Pathway map
map00760  Nicotinate and nicotinamide metabolism
map00760

Ortholog table
Module
M00115  NAD biosynthesis, aspartate => NAD [PATH:map00760]
M00622  Nicotinate degradation, nicotinate => fumarate [PATH:map00760]
M00810  Nicotine degradation, pyridine pathway, nicotine => 2,6-dihydroxypyridine/succinate semialdehyde [PATH:map00760]
M00811  Nicotine degradation, pyrrolidine pathway, nicotine => succinate semialdehyde [PATH:map00760]
Disease
H00824  Calcification of joints and arteries
H01002  Generalized arterial calcification of infancy
H01394  Cole disease
H01929  2,4-Dienoyl-CoA reductase deficiency
Other DBs
UMBBD: nic
GO: 0006769
Reference
  Authors
BEHRMAN EJ, STANIER RY.
  Title
The bacterial oxidation of nicotinic acid.
  Journal
J Biol Chem 228:923-45 (1957)
Reference
  Authors
Alhapel A, Darley DJ, Wagener N, Eckel E, Elsner N, Pierik AJ.
  Title
Molecular and functional analysis of nicotinate catabolism in Eubacterium barkeri.
  Journal
Proc Natl Acad Sci U S A 103:12341-6 (2006)
DOI:10.1073/pnas.0601635103
Reference
  Authors
Baitsch D, Sandu C, Brandsch R, Igloi GL.
  Title
Gene cluster on pAO1 of Arthrobacter nicotinovorans involved in degradation of the plant alkaloid nicotine: cloning, purification, and characterization of 2,6-dihydroxypyridine 3-hydroxylase.
  Journal
J Bacteriol 183:5262-7 (2001)
DOI:10.1128/JB.183.18.5262-5267.2001
Reference
  Authors
Sachelaru P, Schiltz E, Igloi GL, Brandsch R.
  Title
An alpha/beta-fold C--C bond hydrolase is involved in a central step of nicotine catabolism by Arthrobacter nicotinovorans.
  Journal
J Bacteriol 187:8516-9 (2005)
DOI:10.1128/JB.187.24.8516-8519.2005
Reference
PMID:5835946
  Authors
Gherna RL, Richardson SH, Rittenberg SC
  Title
The bacterial oxidation of nicotine. VI. The metabolism of 2,6-dihydroxypseudooxynicotine.
  Journal
J Biol Chem 240:3669-74 (1965)
Reference
  Authors
Galeazzi L, Bocci P, Amici A, Brunetti L, Ruggieri S, Romine M, Reed S, Osterman AL, Rodionov DA, Sorci L, Raffaelli N
  Title
Identification of nicotinamide mononucleotide deamidase of the bacterial pyridine nucleotide cycle reveals a novel broadly conserved amidohydrolase family.
  Journal
J Biol Chem 286:40365-75 (2011)
DOI:10.1074/jbc.M111.275818
KO pathway
ko00760   

  All links  
Pathway (4)   
   KEGG MODULE (4)   
Disease (4)   
   KEGG DISEASE (4)   
Chemical substance (55)   
   KEGG COMPOUND (55)   
Chemical reaction (136)   
   KEGG ENZYME (59)   
   KEGG REACTION (77)   
Gene (259179)   
   KEGG ORTHOLOGY (89)   
   RefGene (259090)   
Literature (6)   
   PubMed (6)   
All databases (259384)   

Download RDF
DBGET integrated database retrieval system