Entry Name Porphyrin metabolism
Description Porphyrins are a group of chemical compounds with the backbone ring structure consisting of four linked pyrrole units. Metal complexes of porphyrins, as well as those of corrinoids with the one-carbon shorter ring structure, play important biological roles. They include iron-containing heme, magnesium-containing chlorophyll, nickel-containing coenzyme F430 and cobalt-containing cobamide (such as vitamin B12 coenzyme) as shown in this map.
Class Metabolism; Metabolism of cofactors and vitaminsBRITE hierarchy
Pathway map Module M00121 Heme biosynthesis, plants and bacteria, glutamate => heme [PATH:map00860 ]
M00122 Cobalamin biosynthesis, cobyrinate a,c-diamide => cobalamin [PATH:map00860 ]
M00836 Coenzyme F430 biosynthesis, sirohydrochlorin => coenzyme F430 [PATH:map00860 ]
M00846 Siroheme biosynthesis, glutamyl-tRNA => siroheme [PATH:map00860 ]
M00868 Heme biosynthesis, animals and fungi, glycine => heme [PATH:map00860 ]
M00924 Cobalamin biosynthesis, anaerobic, uroporphyrinogen III => sirohydrochlorin => cobyrinate a,c-diamide [PATH:map00860 ]
M00925 Cobalamin biosynthesis, aerobic, uroporphyrinogen III => precorrin 2 => cobyrinate a,c-diamide [PATH:map00860 ]
M00926 Heme biosynthesis, bacteria, glutamyl-tRNA => coproporphyrin III => heme [PATH:map00860 ]
Other DBs Reference Authors Woodcock SC, Raux E, Levillayer F, Thermes C, Rambach A, Warren MJ.
Title Effect of mutations in the transmethylase and dehydrogenase/chelatase domains of sirohaem synthase (CysG) on sirohaem and cobalamin biosynthesis.
Journal Reference Authors Johansson P, Hederstedt L
Title Organization of genes for tetrapyrrole biosynthesis in gram--positive bacteria.
Journal Reference Authors Maggio-Hall LA, Escalante-Semerena JC.
Title In vitro synthesis of the nucleotide loop of cobalamin by Salmonella typhimurium enzymes.
Journal Reference Authors Roper JM, Raux E, Brindley AA, Schubert HL, Gharbia SE, Shah HN, Warren MJ.
Title The enigma of cobalamin (Vitamin B12) biosynthesis in Porphyromonas gingivalis. Identification and characterization of a functional corrin pathway.
Journal Reference Authors Scott AI, Roessner CA.
Title Biosynthesis of cobalamin (vitamin B(12)).
Journal Reference Authors Warren MJ, Raux E, Schubert HL, Escalante-Semerena JC.
Title The biosynthesis of adenosylcobalamin (vitamin B12).
Journal Reference Authors Roessner CA, Huang KX, Warren MJ, Raux E, Scott AI.
Title Isolation and characterization of 14 additional genes specifying the anaerobic biosynthesis of cobalamin (vitamin B12) in Propionibacterium freudenreichii (P. shermanii).
Journal Reference Authors Frankenberg N, Mukougawa K, Kohchi T, Lagarias JC.
Title Functional genomic analysis of the HY2 family of ferredoxin-dependent bilin reductases from oxygenic photosynthetic organisms.
Journal Reference Authors Chew AG, Bryant DA
Title Chlorophyll biosynthesis in bacteria: the origins of structural and functional diversity.
Journal Reference Authors Frigaard NU, Chew AG, Li H, Maresca JA, Bryant DA
Title Chlorobium tepidum: insights into the structure, physiology, and metabolism of a green sulfur bacterium derived from the complete genome sequence.
Journal Reference Authors Deery E, Schroeder S, Lawrence AD, Taylor SL, Seyedarabi A, Waterman J, Wilson KS, Brown D, Geeves MA, Howard MJ, Pickersgill RW, Warren MJ
Title An enzyme-trap approach allows isolation of intermediates in cobalamin biosynthesis.
Journal Reference Authors Moore SJ, Lawrence AD, Biedendieck R, Deery E, Frank S, Howard MJ, Rigby SE, Warren MJ
Title Elucidation of the anaerobic pathway for the corrin component of cobalamin (vitamin B12).
Journal Related map00250 Alanine, aspartate and glutamate metabolism
map00260 Glycine, serine and threonine metabolism
KO pathway
