Entry |
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Name |
Porphyrin and chlorophyll metabolism
|
Class |
Metabolism; Metabolism of cofactors and vitamins
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Pathway map |
map00860 | Porphyrin and chlorophyll metabolism |

|
Module |
M00121 | Heme biosynthesis, plants and bacteria, glutamate => heme [PATH:map00860] |
M00122 | Cobalamin biosynthesis, cobyrinate a,c-diamide => cobalamin [PATH:map00860] |
M00836 | Coenzyme F430 biosynthesis, sirohydrochlorin => coenzyme F430 [PATH:map00860] |
M00846 | Siroheme biosynthesis, glutamyl-tRNA => siroheme [PATH:map00860] |
M00868 | Heme biosynthesis, animals and fungi, glycine => heme [PATH:map00860] |
M00924 | Cobalamin biosynthesis, anaerobic, uroporphyrinogen III => sirohydrochlorin => cobyrinate a,c-diamide [PATH:map00860] |
M00925 | Cobalamin biosynthesis, aerobic, uroporphyrinogen III => precorrin 2 => cobyrinate a,c-diamide [PATH:map00860] |
M00926 | Heme biosynthesis, bacteria, glutamyl-tRNA => coproporphyrin III => heme [PATH:map00860] |
|
Disease |
H01368 | Cytochrome c oxidase (COX) deficiency |
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Other DBs |
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Reference |
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Authors |
Woodcock SC, Raux E, Levillayer F, Thermes C, Rambach A, Warren MJ. |
Title |
Effect of mutations in the transmethylase and dehydrogenase/chelatase domains of sirohaem synthase (CysG) on sirohaem and cobalamin biosynthesis. |
Journal |
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Reference |
|
Authors |
Johansson P, Hederstedt L |
Title |
Organization of genes for tetrapyrrole biosynthesis in gram--positive bacteria. |
Journal |
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Reference |
|
Authors |
Maggio-Hall LA, Escalante-Semerena JC. |
Title |
In vitro synthesis of the nucleotide loop of cobalamin by Salmonella typhimurium enzymes. |
Journal |
|
Reference |
|
Authors |
Roper JM, Raux E, Brindley AA, Schubert HL, Gharbia SE, Shah HN, Warren MJ. |
Title |
The enigma of cobalamin (Vitamin B12) biosynthesis in Porphyromonas gingivalis. Identification and characterization of a functional corrin pathway. |
Journal |
|
Reference |
|
Authors |
Scott AI, Roessner CA. |
Title |
Biosynthesis of cobalamin (vitamin B(12)). |
Journal |
|
Reference |
|
Authors |
Warren MJ, Raux E, Schubert HL, Escalante-Semerena JC. |
Title |
The biosynthesis of adenosylcobalamin (vitamin B12). |
Journal |
|
Reference |
|
Authors |
Roessner CA, Huang KX, Warren MJ, Raux E, Scott AI. |
Title |
Isolation and characterization of 14 additional genes specifying the anaerobic biosynthesis of cobalamin (vitamin B12) in Propionibacterium freudenreichii (P. shermanii). |
Journal |
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Reference |
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Authors |
Frankenberg N, Mukougawa K, Kohchi T, Lagarias JC. |
Title |
Functional genomic analysis of the HY2 family of ferredoxin-dependent bilin reductases from oxygenic photosynthetic organisms. |
Journal |
|
Reference |
|
Authors |
Chew AG, Bryant DA |
Title |
Chlorophyll biosynthesis in bacteria: the origins of structural and functional diversity. |
Journal |
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Reference |
|
Authors |
Frigaard NU, Chew AG, Li H, Maresca JA, Bryant DA |
Title |
Chlorobium tepidum: insights into the structure, physiology, and metabolism of a green sulfur bacterium derived from the complete genome sequence. |
Journal |
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Reference |
|
Authors |
Deery E, Schroeder S, Lawrence AD, Taylor SL, Seyedarabi A, Waterman J, Wilson KS, Brown D, Geeves MA, Howard MJ, Pickersgill RW, Warren MJ |
Title |
An enzyme-trap approach allows isolation of intermediates in cobalamin biosynthesis. |
Journal |
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Reference |
|
Authors |
Moore SJ, Lawrence AD, Biedendieck R, Deery E, Frank S, Howard MJ, Rigby SE, Warren MJ |
Title |
Elucidation of the anaerobic pathway for the corrin component of cobalamin (vitamin B12). |
Journal |
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Related pathway |
map00250 | Alanine, aspartate and glutamate metabolism |
map00260 | Glycine, serine and threonine metabolism |
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KO pathway |
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