KEGG   PATHWAY: map01040Help
Entry
map01040                    Pathway                                

Name
Biosynthesis of unsaturated fatty acids
Class
Metabolism; Lipid metabolism
BRITE hierarchy
Pathway map
map01040  Biosynthesis of unsaturated fatty acids
map01040

Ortholog table
Module
M00415  Fatty acid biosynthesis, elongation, endoplasmic reticulum [PATH:map01040]
M00861  beta-Oxidation, peroxisome, VLCFA [PATH:map01040]
Disease
H00407  Peroxisomal beta-oxidation enzyme deficiency
H00819  Stargardt disease
H02098  D-bifunctional protein deficiency
Reference
  Authors
Jakobsson A, Westerberg R, Jacobsson A.
  Title
Fatty acid elongases in mammals: their regulation and roles in metabolism.
  Journal
Prog Lipid Res 45:237-49 (2006)
DOI:10.1016/j.plipres.2006.01.004
Reference
  Authors
Moon YA, Horton JD.
  Title
Identification of two mammalian reductases involved in the two-carbon fatty acyl elongation cascade.
  Journal
J Biol Chem 278:7335-43 (2003)
DOI:10.1074/jbc.M211684200
Reference
  Authors
Han G, Gable K, Kohlwein SD, Beaudoin F, Napier JA, Dunn TM.
  Title
The Saccharomyces cerevisiae YBR159w gene encodes the 3-ketoreductase of the microsomal fatty acid elongase.
  Journal
J Biol Chem 277:35440-9 (2002)
DOI:10.1074/jbc.M205620200
Reference
  Authors
Su HM, Moser AB, Moser HW, Watkins PA.
  Title
Peroxisomal straight-chain Acyl-CoA oxidase and D-bifunctional protein are essential for the retroconversion step in docosahexaenoic acid synthesis.
  Journal
J Biol Chem 276:38115-20 (2001)
DOI:10.1074/jbc.M106326200
Reference
  Authors
Huyghe S, Mannaerts GP, Baes M, Van Veldhoven PP.
  Title
Peroxisomal multifunctional protein-2: the enzyme, the patients and the knockout mouse model.
  Journal
Biochim Biophys Acta 1761:973-94 (2006)
DOI:10.1016/j.bbalip.2006.04.006
Reference
  Authors
Denic V, Weissman JS
  Title
A molecular caliper mechanism for determining very long-chain fatty acid length.
  Journal
Cell 130:663-77 (2007)
DOI:10.1016/j.cell.2007.06.031
Reference
  Authors
Ichi I, Kono N, Arita Y, Haga S, Arisawa K, Yamano M, Nagase M, Fujiwara Y, Arai H
  Title
Identification of genes and pathways involved in the synthesis of Mead acid (20:3n-9), an indicator of essential fatty acid deficiency.
  Journal
Biochim Biophys Acta 1841:204-13 (2014)
DOI:10.1016/j.bbalip.2013.10.013
Reference
  Authors
Guillou H, Zadravec D, Martin PG, Jacobsson A
  Title
The key roles of elongases and desaturases in mammalian fatty acid metabolism: Insights from transgenic mice.
  Journal
Prog Lipid Res 49:186-99 (2010)
DOI:10.1016/j.plipres.2009.12.002
Reference
  Authors
Yu M, Benham A, Logan S, Brush RS, Mandal MN, Anderson RE, Agbaga MP
  Title
ELOVL4 protein preferentially elongates 20:5n3 to very long chain PUFAs over 20:4n6 and 22:6n3.
  Journal
J Lipid Res 53:494-504 (2012)
DOI:10.1194/jlr.M021386
Reference
  Authors
Sawai M, Uchida Y, Ohno Y, Miyamoto M, Nishioka C, Itohara S, Sassa T, Kihara A
  Title
The 3-hydroxyacyl-CoA dehydratases HACD1 and HACD2 exhibit functional redundancy and are active in a wide range of fatty acid elongation pathways.
  Journal
J Biol Chem 292:15538-15551 (2017)
DOI:10.1074/jbc.M117.803171
Reference
  Authors
Ohno Y, Suto S, Yamanaka M, Mizutani Y, Mitsutake S, Igarashi Y, Sassa T, Kihara A
  Title
ELOVL1 production of C24 acyl-CoAs is linked to C24 sphingolipid synthesis.
  Journal
Proc Natl Acad Sci U S A 107:18439-44 (2010)
DOI:10.1073/pnas.1005572107
Reference
  Authors
Naganuma T, Sato Y, Sassa T, Ohno Y, Kihara A
  Title
Biochemical characterization of the very long-chain fatty acid elongase ELOVL7.
  Journal
FEBS Lett 585:3337-41 (2011)
DOI:10.1016/j.febslet.2011.09.024
Reference
  Authors
Tamura K, Makino A, Hullin-Matsuda F, Kobayashi T, Furihata M, Chung S, Ashida S, Miki T, Fujioka T, Shuin T, Nakamura Y, Nakagawa H
  Title
Novel lipogenic enzyme ELOVL7 is involved in prostate cancer growth through saturated long-chain fatty acid metabolism.
  Journal
Cancer Res 69:8133-40 (2009)
DOI:10.1158/0008-5472.CAN-09-0775
Reference
  Authors
Uemura H
  Title
Synthesis and production of unsaturated and polyunsaturated fatty acids in yeast: current state and perspectives.
  Journal
Appl Microbiol Biotechnol 95:1-12 (2012)
DOI:10.1007/s00253-012-4105-1
Reference
  Authors
Ferdinandusse S, Denis S, Mooijer PA, Zhang Z, Reddy JK, Spector AA, Wanders RJ
  Title
Identification of the peroxisomal beta-oxidation enzymes involved in the biosynthesis of docosahexaenoic acid.
  Journal
J Lipid Res 42:1987-95 (2001)
KO pathway
ko01040   

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