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Entry
map02010                    Pathway                                

Name
ABC transporters
Description
The ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of a wide variety of substrates such as ions, sugars, lipids, sterols, peptides, proteins, and drugs. The structure of a prokaryotic ABC transporter usually consists of three components; typically two integral membrane proteins each having six transmembrane segments, two peripheral proteins that bind and hydrolyze ATP, and a periplasmic (or lipoprotein) substrate-binding protein. Many of the genes for the three components form operons as in fact observed in many bacterial and archaeal genomes. On the other hand, in a typical eukaryotic ABC transporter, the membrane spanning protein and the ATP-binding protein are fused, forming a multi-domain protein with the membrane-spanning domain (MSD) and the nucleotide-binding domain (NBD).
Class
Environmental Information Processing; Membrane transport
BRITE hierarchy
Pathway map
map02010  ABC transporters
map02010

Ortholog table
Module
M00185  Sulfate transport system [PATH:map02010]
M00186  Tungstate transport system [PATH:map02010]
M00189  Molybdate transport system [PATH:map02010]
M00190  Iron(III) transport system [PATH:map02010]
M00191  Thiamine transport system [PATH:map02010]
M00194  Maltose/maltodextrin transport system [PATH:map02010]
M00196  Raffinose/stachyose/melibiose transport system [PATH:map02010]
M00198  Putative sn-glycerol-phosphate transport system [PATH:map02010]
M00199  L-Arabinose/lactose transport system [PATH:map02010]
M00200  Putative sorbitol/mannitol transport system [PATH:map02010]
M00201  alpha-Glucoside transport system [PATH:map02010]
M00202  Oligogalacturonide transport system [PATH:map02010]
M00203  Glucose/arabinose transport system [PATH:map02010]
M00204  Trehalose/maltose transport system [PATH:map02010]
M00205  N-Acetylglucosamine transport system [PATH:map02010]
M00206  Cellobiose transport system [PATH:map02010]
M00208  Glycine betaine/proline transport system [PATH:map02010]
M00209  Osmoprotectant transport system [PATH:map02010]
M00210  Phospholipid transport system [PATH:map02010]
M00212  Ribose transport system [PATH:map02010]
M00213  L-Arabinose transport system [PATH:map02010]
M00214  Methyl-galactoside transport system [PATH:map02010]
M00215  D-Xylose transport system [PATH:map02010]
M00216  Multiple sugar transport system [PATH:map02010]
M00217  D-Allose transport system [PATH:map02010]
M00218  Fructose transport system [PATH:map02010]
M00219  AI-2 transport system [PATH:map02010]
M00220  Rhamnose transport system [PATH:map02010]
M00222  Phosphate transport system [PATH:map02010]
M00223  Phosphonate transport system [PATH:map02010]
M00224  Fluoroquinolone transport system [PATH:map02010]
M00225  Lysine/arginine/ornithine transport system [PATH:map02010]
M00226  Histidine transport system [PATH:map02010]
M00227  Glutamine transport system [PATH:map02010]
M00228  Putative glutamine transport system [PATH:map02010]
M00229  Arginine transport system [PATH:map02010]
M00230  Glutamate/aspartate transport system [PATH:map02010]
M00231  Octopine/nopaline transport system [PATH:map02010]
M00232  General L-amino acid transport system [PATH:map02010]
M00233  Glutamate transport system [PATH:map02010]
M00234  Cystine transport system [PATH:map02010]
M00235  Arginine/ornithine transport system [PATH:map02010]
M00237  Branched-chain amino acid transport system [PATH:map02010]
M00238  D-Methionine transport system [PATH:map02010]
M00239  Peptides/nickel transport system [PATH:map02010]
M00240  Iron complex transport system [PATH:map02010]
M00241  Vitamin B12 transport system [PATH:map02010]
M00242  Zinc transport system [PATH:map02010]
M00245  Cobalt/nickel transport system [PATH:map02010]
M00246  Nickel transport system [PATH:map02010]
M00249  Capsular polysaccharide transport system [PATH:map02010]
M00250  Lipopolysaccharide transport system [PATH:map02010]
M00251  Teichoic acid transport system [PATH:map02010]
M00252  Lipooligosaccharide transport system [PATH:map02010]
M00253  Sodium transport system [PATH:map02010]
M00255  Lipoprotein-releasing system [PATH:map02010]
M00256  Cell division transport system [PATH:map02010]
M00257  Hemin transport system [PATH:map02010]
M00259  Heme transport system [PATH:map02010]
M00298  Multidrug/hemolysin transport system [PATH:map02010]
M00299  Spermidine/putrescine transport system [PATH:map02010]
M00300  Putrescine transport system [PATH:map02010]
M00301  Mannopine transport system [PATH:map02010]
M00302  2-Aminoethylphosphonate transport system [PATH:map02010]
M00314  Bacitracin transport system [PATH:map02010]
M00316  Manganese transport system [PATH:map02010]
M00317  Manganese/iron transport system [PATH:map02010]
M00318  Iron/zinc/manganese/copper transport system [PATH:map02010]
M00319  Manganese/zinc/iron transport system [PATH:map02010]
M00320  Lipopolysaccharide export system [PATH:map02010]
M00321  Bicarbonate transport system [PATH:map02010]
M00322  Neutral amino acid transport system [PATH:map02010]
M00323  Urea transport system [PATH:map02010]
M00324  Dipeptide transport system [PATH:map02010]
M00325  alpha-Hemolysin/cyclolysin transport system [PATH:map02010]
M00348  Glutathione transport system [PATH:map02010]
M00349  Microcin C transport system [PATH:map02010]
M00423  Molybdate/tungstate transport system [PATH:map02010]
M00435  Taurine transport system [PATH:map02010]
M00436  Sulfonate transport system [PATH:map02010]
M00437  Phthalate transport system [PATH:map02010]
M00438  Nitrate/nitrite transport system [PATH:map02010]
M00439  Oligopeptide transport system [PATH:map02010]
M00440  Nickel transport system [PATH:map02010]
M00442  Putative hydroxymethylpyrimidine transport system [PATH:map02010]
M00491  arabinogalactan oligomer/maltooligosaccharide transport system [PATH:map02010]
M00566  Dipeptide transport system, Firmicutes [PATH:map02010]
M00581  Biotin transport system [PATH:map02010]
M00582  Energy-coupling factor transport system [PATH:map02010]
M00583  Putative peptide transport system [PATH:map02010]
M00584  Acetoin utilization transport system [PATH:map02010]
M00585  L-Cystine transport system [PATH:map02010]
M00586  Putative amino-acid transport system [PATH:map02010]
M00587  Arginine/lysine/histidine/glutamine transport system [PATH:map02010]
M00589  Putative lysine transport system [PATH:map02010]
M00590  Erythritol transport system [PATH:map02010]
M00591  Putative xylitol transport system [PATH:map02010]
M00592  Inositol transport system [PATH:map02010]
M00593  Inositol transport system [PATH:map02010]
M00599  Inositol-phosphate transport system [PATH:map02010]
M00600  alpha-1,4-Digalacturonate transport system [PATH:map02010]
M00601  Putative chitobiose transport system [PATH:map02010]
M00602  Arabinosaccharide transport system [PATH:map02010]
M00603  Putative aldouronate transport system [PATH:map02010]
M00604  Trehalose transport system [PATH:map02010]
M00605  Glucose/mannose transport system [PATH:map02010]
M00606  N,N'-Diacetylchitobiose transport system [PATH:map02010]
M00607  Glycerol transport system [PATH:map02010]
M00619  Xylobiose transport system [PATH:map02010]
M00634  Oleandomycin transport system [PATH:map02010]
M00635  Tetracycline resistance, TetAB(46) transporter [PATH:map02010]
M00731  Bacitracin transport system [PATH:map02010]
M00732  Cationic antimicrobial peptide transport system [PATH:map02010]
M00739  Cationic peptide transport system [PATH:map02010]
M00747  Bacitracin transport system [PATH:map02010]
M00762  Copper-processing system [PATH:map02010]
M00791  Manganese/zinc transport system [PATH:map02010]
M00792  Manganese/zinc transport system [PATH:map02010]
M00813  Lantibiotic transport system [PATH:map02010]
M00817  Lantibiotic transport system [PATH:map02010]
M00858  Vi polysaccharide transport system [PATH:map02010]
Disease
H00152  Sitosterolemia
H00159  Tangier disease
H00176  Adrenoleukodystrophy
H00208  Hyperbilirubinemia
H00218  Cystic fibrosis
H00560  Pseudoxanthoma elasticum
H00733  Harlequin ichthyosis
H00819  Stargardt disease
H00930  Hypoalphalipoproteinemia
H00984  Bare lymphocyte syndrome type1
H01033  Congenital bilateral absence of vas deferens
H01213  Gallbladder disease
H01267  Familial hyperinsulinemic hypoglycemia
H02056  Dubin-Johnson syndrome
Other DBs
GO: 0043190 0043191 0043192
TC: 3.A.1
Reference
PMID:9799792
  Authors
Tomii K, Kanehisa M.
  Title
A comparative analysis of ABC transporters in complete microbial genomes.
  Journal
Genome Res 8:1048-59 (1998)
DOI:10.1101/gr.8.10.1048
Reference
  Authors
Sperandeo P, Lau FK, Carpentieri A, De Castro C, Molinaro A, Deho G, Silhavy TJ, Polissi A
  Title
Functional analysis of the protein machinery required for transport of lipopolysaccharide to the outer membrane of Escherichia coli.
  Journal
J Bacteriol 190:4460-9 (2008)
DOI:10.1128/JB.00270-08
Reference
  Authors
Ruiz N, Gronenberg LS, Kahne D, Silhavy TJ
  Title
Identification of two inner-membrane proteins required for the transport of lipopolysaccharide to the outer membrane of Escherichia coli.
  Journal
Proc Natl Acad Sci U S A 105:5537-42 (2008)
DOI:10.1073/pnas.0801196105
Reference
  Authors
Omata T, Price GD, Badger MR, Okamura M, Gohta S, Ogawa T
  Title
Identification of an ATP-binding cassette transporter involved in bicarbonate uptake in the cyanobacterium Synechococcus sp. strain PCC 7942.
  Journal
Proc Natl Acad Sci U S A 96:13571-6 (1999)
DOI:10.1073/pnas.96.23.13571
Reference
  Authors
Quintero MJ, Montesinos ML, Herrero A, Flores E
  Title
Identification of genes encoding amino acid permeases by inactivation of selected ORFs from the Synechocystis genomic sequence.
  Journal
Genome Res 11:2034-40 (2001)
DOI:10.1101/gr.196301
Reference
  Authors
Picossi S, Montesinos ML, Pernil R, Lichtle C, Herrero A, Flores E
  Title
ABC-type neutral amino acid permease N-I is required for optimal diazotrophic growth and is repressed in the heterocysts of Anabaena sp. strain PCC 7120.
  Journal
Mol Microbiol 57:1582-92 (2005)
DOI:10.1111/j.1365-2958.2005.04791.x
Reference
  Authors
Valladares A, Montesinos ML, Herrero A, Flores E.
  Title
An ABC-type, high-affinity urea permease identified in cyanobacteria.
  Journal
Mol Microbiol 43:703-15 (2002)
DOI:10.1046/j.1365-2958.2002.02778.x
Reference
  Authors
Richard-Fogal CL, Frawley ER, Kranz RG
  Title
Topology and function of CcmD in cytochrome c maturation.
  Journal
J Bacteriol 190:3489-93 (2008)
DOI:10.1128/JB.00146-08
Reference
  Authors
Suzuki H, Koyanagi T, Izuka S, Onishi A, Kumagai H
  Title
The yliA, -B, -C, and -D genes of Escherichia coli K-12 encode a novel glutathione importer with an ATP-binding cassette.
  Journal
J Bacteriol 187:5861-7 (2005)
DOI:10.1128/JB.187.17.5861-5867.2005
Reference
  Authors
Novikova M, Metlitskaya A, Datsenko K, Kazakov T, Kazakov A, Wanner B, Severinov K
  Title
The Escherichia coli Yej transporter is required for the uptake of translation inhibitor microcin C.
  Journal
J Bacteriol 189:8361-5 (2007)
DOI:10.1128/JB.01028-07
Reference
  Authors
Tikhonova EB, Devroy VK, Lau SY, Zgurskaya HI
  Title
Reconstitution of the Escherichia coli macrolide transporter: the periplasmic membrane fusion protein MacA stimulates the ATPase activity of MacB.
  Journal
Mol Microbiol 63:895-910 (2007)
DOI:10.1111/j.1365-2958.2006.05549.x
Reference
  Authors
Yamanaka H, Kobayashi H, Takahashi E, Okamoto K
  Title
MacAB is involved in the secretion of Escherichia coli heat-stable enterotoxin II.
  Journal
J Bacteriol 190:7693-8 (2008)
DOI:10.1128/JB.00853-08
KO pathway
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