KEGG   PATHWAY: map02060Help
Entry
map02060                    Pathway                                

Name
Phosphotransferase system (PTS)
Description
The phosphoenolpyruvate (PEP)-dependent phosphotransferase system (PTS) is a major mechanism used by bacteria for uptake of carbohydrates, particularly hexoses, hexitols, and disaccharides, where the source of energy is from PEP. The PTS consists of two general components, enzyme I (EI) and histidine phosphocarrier protein (HPr), and of membrane-bound sugar specific permeases (enzymes II). Each enzyme II (EII) complex consists of one or two hydrophobic integral membrane domains (domains C and D) and two hydrophilic domains (domains A and B). EII complexes may exist as distinct proteins or as a single multidomain protein. The PTS catalyzes the uptake of carbohydrates and their conversion into their respective phosphoesters during transport. There are four successive phosphoryl transfers in the PTS. Initial autophosphorylation of EI, using PEP as a substrate, is followed by transfer of the phosphoryl group from EI to HPr. EIIA catalyzes the self-phosphoryl transfer from HPr after which the phosphoryl group is transferred to histidine or cysteine residues of EIIB. The sugar is transported through the membrane-bound EIIC and is phosphorylated by the appropriate sugar-specific EIIB.
Class
Environmental Information Processing; Membrane transport
BRITE hierarchy
Pathway map
map02060  Phosphotransferase system (PTS)
map02060

Ortholog table
Module
M00265  PTS system, glucose-specific II component [PATH:map02060]
M00266  PTS system, maltose/glucose-specific II component [PATH:map02060]
M00267  PTS system, N-acetylglucosamine-specific II component [PATH:map02060]
M00268  PTS system, alpha-glucoside-specific II component [PATH:map02060]
M00269  PTS system, sucrose-specific II component [PATH:map02060]
M00270  PTS system, trehalose-specific II component [PATH:map02060]
M00271  PTS system, beta-glucoside-specific II component [PATH:map02060]
M00272  PTS system, beta-glucoside (arbutin/salicin/cellobiose)-specific II component [PATH:map02060]
M00273  PTS system, fructose-specific II component [PATH:map02060]
M00274  PTS system, mannitol-specific II component [PATH:map02060]
M00275  PTS system, cellobiose-specific II component [PATH:map02060]
M00276  PTS system, mannose-specific II component [PATH:map02060]
M00277  PTS system, N-acetylgalactosamine-specific II component [PATH:map02060]
M00278  PTS system, sorbose-specific II component [PATH:map02060]
M00279  PTS system, galactitol-specific II component [PATH:map02060]
M00280  PTS system, glucitol/sorbitol-specific II component [PATH:map02060]
M00281  PTS system, lactose-specific II component [PATH:map02060]
M00282  PTS system, D-glucosamine-specific II component [PATH:map02060]
M00283  PTS system, ascorbate-specific II component [PATH:map02060]
M00287  PTS system, galactosamine-specific II component [PATH:map02060]
M00303  PTS system, N-acetylmuramic acid-specific II component [PATH:map02060]
M00304  PTS system, fructose-specific II component [PATH:map02060]
M00305  PTS system, 2-O-A-mannosyl-D-glycerate-specific II component [PATH:map02060]
M00610  PTS system, D-glucosaminate-specific II component [PATH:map02060]
M00764  PTS system, fructoselysine/glucoselysine-specific II component [PATH:map02060]
M00806  PTS system, maltose-specific II component [PATH:map02060]
M00807  PTS system, galactose-specific II component [PATH:map02060]
M00809  PTS system, glucose-specific II component [PATH:map02060]
Other DBs
GO: 0009401
TC: 4.A
Reference
  Authors
Darbon E, Galinier A, Le Coq D, Deutscher J.
  Title
Phosphotransfer functions mutated Bacillus subtilis HPr-like protein Crh carrying a histidine in the active site.
  Journal
J Mol Microbiol Biotechnol 3:439-44 (2001)
Reference
  Authors
Dahl U, Jaeger T, Nguyen BT, Sattler JM, Mayer C.
  Title
Identification of a phosphotransferase system of Escherichia coli required for growth on N-acetylmuramic acid.
  Journal
J Bacteriol 186:2385-92 (2004)
DOI:10.1128/JB.186.8.2385-2392.2004
Reference
PMID:2117666
  Authors
Martin-Verstraete I, Debarbouille M, Klier A, Rapoport G
  Title
Levanase operon of Bacillus subtilis includes a fructose-specific phosphotransferase system regulating the expression of the operon.
  Journal
J Mol Biol 214:657-71 (1990)
DOI:10.1016/0022-2836(90)90284-S
Reference
  Authors
Kristich CJ, Glekas GD, Ordal GW.
  Title
The conserved cytoplasmic module of the transmembrane chemoreceptor McpC mediates carbohydrate chemotaxis in Bacillus subtilis.
  Journal
Mol Microbiol 47:1353-66 (2003)
DOI:10.1046/j.1365-2958.2003.03375.x
Reference
  Authors
Sampaio MM, Chevance F, Dippel R, Eppler T, Schlegel A, Boos W, Lu YJ, Rock CO.
  Title
Phosphotransferase-mediated transport of the osmolyte 2-O-alpha-mannosyl-D-glycerate in Escherichia coli occurs by the product of the mngA (hrsA) gene and is regulated by the mngR (farR) gene product acting as repressor.
  Journal
J Biol Chem 279:5537-48 (2004)
DOI:10.1074/jbc.M310980200
Reference
  Authors
Keseler IM, Collado-Vides J, Gama-Castro S, Ingraham J, Paley S, Paulsen IT, Peralta-Gil M, Karp PD.
  Title
EcoCyc: a comprehensive database resource for Escherichia coli.
  Journal
Nucleic Acids Res 33:D334-7 (2005)
DOI:10.1093/nar/gki108
Reference
  Authors
Mukherjee A, Mammel MK, LeClerc JE, Cebula TA.
  Title
Altered utilization of N-acetyl-D-galactosamine by Escherichia coli O157:H7 from the 2006 spinach outbreak.
  Journal
J Bacteriol 190:1710-7 (2008)
DOI:10.1128/JB.01737-07
Reference
  Authors
Brinkkotter A, Kloss H, Alpert C, Lengeler JW.
  Title
Pathways for the utilization of N-acetyl-galactosamine and galactosamine in Escherichia coli.
  Journal
Mol Microbiol 37:125-35 (2000)
DOI:10.1046/j.1365-2958.2000.01969.x
Reference
  Authors
Tchieu JH, Norris V, Edwards JS, Saier MH Jr.
  Title
The complete phosphotranferase system in Escherichia coli.
  Journal
J Mol Microbiol Biotechnol 3:329-46 (2001)
Reference
  Authors
Kotrba P, Inui M, Yukawa H.
  Title
Bacterial phosphotransferase system (PTS) in carbohydrate uptake and control of carbon metabolism.
  Journal
J Biosci Bioeng 92:502-17 (2001)
DOI:10.1016/S1389-1723(01)80308-X
KO pathway
ko02060   

DBGET integrated database retrieval system