Entry |
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Name |
Cytokine-cytokine receptor interaction
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Description |
Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped.
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Class |
Environmental Information Processing; Signaling molecules and interaction
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Pathway map |
map04060 | Cytokine-cytokine receptor interaction |

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Disease |
H00935 | Cold-induced sweating syndrome |
H01023 | Juvenile polyposis syndrome |
H01024 | Hereditary mixed polyposis syndrome |
H01109 | Chronic mucocutaneous candidiasis |
H01122 | Congenital pulmonary alveolar proteinosis |
H01217 | Primary localized cutaneous amyloidosis |
H01227 | Inflammatory bowel disease (IBD) |
H02254 | Craniosynostosis and dental anomalies |
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Reference |
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Authors |
Turner MD, Nedjai B, Hurst T, Pennington DJ |
Title |
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease. |
Journal |
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Reference |
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Authors |
Brocker C, Thompson D, Matsumoto A, Nebert DW, Vasiliou V |
Title |
Evolutionary divergence and functions of the human interleukin (IL) gene family. |
Journal |
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Reference |
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Authors |
Akdis M, Aab A, Altunbulakli C, Azkur K, Costa RA, Crameri R, Duan S, Eiwegger T, Eljaszewicz A, Ferstl R, Frei R, Garbani M, Globinska A, Hess L, Huitema C, Kubo T, Komlosi Z, Konieczna P, Kovacs N, Kucuksezer UC, Meyer N, Morita H, Olzhausen J, O'Mahony L, Pezer M, Prati M, Rebane A, Rhyner C, Rinaldi A, Sokolowska M, Stanic B, Sugita K, Treis A, van de Veen W, Wanke K, Wawrzyniak M, Wawrzyniak P, Wirz OF, Zakzuk JS, Akdis CA |
Title |
Interleukins (from IL-1 to IL-38), interferons, transforming growth factor beta, and TNF-alpha: Receptors, functions, and roles in diseases. |
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Reference |
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Authors |
Boulanger MJ, Garcia KC |
Title |
Shared cytokine signaling receptors: structural insights from the gp130 system. |
Journal |
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Reference |
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Authors |
Allan SM, Tyrrell PJ, Rothwell NJ |
Title |
Interleukin-1 and neuronal injury. |
Journal |
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Reference |
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Authors |
Lopetuso LR, Chowdhry S, Pizarro TT |
Title |
Opposing Functions of Classic and Novel IL-1 Family Members in Gut Health and Disease. |
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Reference |
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Authors |
Iwakura Y, Ishigame H, Saijo S, Nakae S |
Title |
Functional specialization of interleukin-17 family members. |
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Reference |
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Authors |
Fischer P, Hilfiker-Kleiner D |
Title |
Survival pathways in hypertrophy and heart failure: the gp130-STAT3 axis. |
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Reference |
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Authors |
Richards CD |
Title |
The enigmatic cytokine oncostatin m and roles in disease. |
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Reference |
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Authors |
Zhang Q, Putheti P, Zhou Q, Liu Q, Gao W |
Title |
Structures and biological functions of IL-31 and IL-31 receptors. |
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Reference |
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Authors |
Meenhuis A, Verwijmeren C, Roovers O, Touw IP |
Title |
The deubiquitinating enzyme DUB2A enhances CSF3 signalling by attenuating lysosomal routing of the CSF3 receptor. |
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Reference |
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Authors |
de Weerd NA, Nguyen T |
Title |
The interferons and their receptors--distribution and regulation. |
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Reference |
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Authors |
Aggarwal BB |
Title |
Signalling pathways of the TNF superfamily: a double-edged sword. |
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Reference |
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Authors |
Ashkenazi A |
Title |
Targeting death and decoy receptors of the tumour-necrosis factor superfamily. |
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Reference |
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Authors |
Seeger P, Musso T, Sozzani S |
Title |
The TGF-beta superfamily in dendritic cell biology. |
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Reference |
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Authors |
Wakefield LM, Hill CS |
Title |
Beyond TGFbeta: roles of other TGFbeta superfamily members in cancer. |
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Reference |
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Authors |
Mueller TD, Nickel J |
Title |
Promiscuity and specificity in BMP receptor activation. |
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KO pathway |
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