KEGG   PATHWAY: map04120Help
Entry
map04120                    Pathway                                

Name
Ubiquitin mediated proteolysis
Description
Protein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to proteins being degraded is performed by a reaction cascade consisting of three enzymes, named E1 (ubiquitin activating enzyme), E2 (ubiquitin conjugating enzyme), and E3 (ubiquitin ligase). Each E3 has specificity to its substrate, or proteins to be targeted by ubiquitination. Many E3s are discovered in eukaryotes and they are classified into four types: HECT type, U-box type, single RING-finger type, and multi-subunit RING-finger type. Multi-subunit RING-finger E3s are exemplified by cullin-Rbx E3s and APC/C. They consist of a RING-finger-containing subunit (RBX1 or RBX2) that functions to bind E2s, a scaffold-like cullin molecule, adaptor proteins, and a target recognizing subunit that binds substrates.
Class
Genetic Information Processing; Folding, sorting and degradation
BRITE hierarchy
Pathway map
map04120  Ubiquitin mediated proteolysis
map04120

Ortholog table
Module
M00379  SCF-MET30 complex [PATH:map04120]
M00380  SCF-BTRC complex [PATH:map04120]
M00381  SCF-SKP2 complex [PATH:map04120]
M00382  SCF-FBS complex [PATH:map04120]
M00383  ECV complex [PATH:map04120]
M00384  Cul3-SPOP complex [PATH:map04120]
M00385  Cul4-DDB1-DDB2 complex [PATH:map04120]
M00386  Cul4-DDB1-CSA complex [PATH:map04120]
M00387  SCF-FBW7 complex [PATH:map04120]
M00388  ECS complex [PATH:map04120]
M00389  APC/C complex [PATH:map04120]
M00407  SCF-CDC4 complex [PATH:map04120]
M00411  SCF-GRR1 complex [PATH:map04120]
Disease
H00509  3M syndrome
H00559  von Hippel-Lindau syndrome
H00583  Opitz-GBBB syndrome
H00593  Limb-girdle muscular dystrophy
H01232  Syndromic multisystem autoimmune disease
H01289  Mulibrey nanism
H01732  Angelman syndrome
H02131  UV-sensitive syndrome
Other DBs
GO: 0016567
Reference
PMID:16922370 (Japanese)
  Authors
Kamura T.
  Title
[Cullin-based E3 family] Japanese
  Journal
Tanpakushitsu Kakusan Koso 51:1167-72 (2006)
Reference
PMID:16922408 (Japanese)
  Authors
Matsuda N.
  Title
[Overview: hereditary disorders caused by dysfunction of ubiquitylation]
  Journal
Tanpakushitsu Kakusan Koso 51:1402-7 (2006)
Reference
PMID:16922367 (Japanese)
  Authors
Tokunaga F.
  Title
[E2 ubiquitin-conjugating enzymes: structures and functions]
  Journal
Tanpakushitsu Kakusan Koso 51:1150-6 (2006)
Reference
  Authors
Nalepa G, Rolfe M, Harper JW.
  Title
Drug discovery in the ubiquitin-proteasome system.
  Journal
Nat Rev Drug Discov 5:596-613 (2006)
DOI:10.1038/nrd2056
Reference
  Authors
Hsu YJ, Goodman SR.
  Title
Spectrin and ubiquitination: a review.
  Journal
Cell Mol Biol (Noisy-le-grand) Suppl 51:OL801-7 (2005)
Reference
  Authors
Hatakeyama S, Nakayama KI.
  Title
Ubiquitylation as a quality control system for intracellular proteins.
  Journal
J Biochem 134:1-8 (2003)
DOI:10.1093/jb/mvg106
Reference
  Authors
Lee J, Zhou P.
  Title
DCAFs, the missing link of the CUL4-DDB1 ubiquitin ligase.
  Journal
Mol Cell 26:775-80 (2007)
DOI:10.1016/j.molcel.2007.06.001
KO pathway
ko04120   

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