KEGG   PATHWAY: map04330Help
Entry
map04330                    Pathway                                

Name
Notch signaling pathway
Description
The Notch signaling pathway is an evolutionarily conserved, intercellular signaling mechanism essential for proper embryonic development in all metazoan organisms in the Animal kingdom. The Notch proteins (Notch1-Notch4 in vertebrates) are single-pass receptors that are activated by the Delta (or Delta-like) and Jagged/Serrate families of membrane-bound ligands. They are transported to the plasma membrane as cleaved, but otherwise intact polypeptides. Interaction with ligand leads to two additional proteolytic cleavages that liberate the Notch intracellular domain (NICD) from the plasma membrane. The NICD translocates to the nucleus, where it forms a complex with the DNA binding protein CSL, displacing a histone deacetylase (HDAc)-co-repressor (CoR) complex from CSL. Components of an activation complex, such as MAML1 and histone acetyltransferases (HATs), are recruited to the NICD-CSL complex, leading to the transcriptional activation of Notch target genes.
Class
Environmental Information Processing; Signal transduction
BRITE hierarchy
Pathway map
map04330  Notch signaling pathway
map04330

Ortholog table
Module
M00682  Notch signaling [PATH:map04330]
Disease
H00078  Frontotemporal lobar degeneration
H00409  Type 2 diabetes mellitus
H00517  Spondylocostal dysostosis
H00536  Cerebral autosomal dominant arteriopathy with subcortical infarcts and leucoencephalopathy (CADASIL)
H00549  Tetralogy of Fallot
H00551  Alagille syndrome
H00554  Bicuspid aortic valve
H00623  Hajdu-Cheney syndrome
H00681  Acne inversa
H01413  Adams-Oliver syndrome
H01508  Salivary gland cancer
H01893  Lateral meningocele syndrome
H01910  Infantile myofibromatosis
Other DBs
GO: 0007219
Reference
  Authors
Hansson EM, Lendahl U, Chapman G.
  Title
Notch signaling in development and disease.
  Journal
Semin Cancer Biol 14:320-8 (2004)
DOI:10.1016/j.semcancer.2004.04.011
Reference
  Authors
Callahan R, Egan SE.
  Title
Notch signaling in mammary development and oncogenesis.
  Journal
J Mammary Gland Biol Neoplasia 9:145-63 (2004)
DOI:10.1023/B:JOMG.0000037159.63644.81
Reference
  Authors
Zweidler-McKay PA, Pear WS.
  Title
Notch and T cell malignancy.
  Journal
Semin Cancer Biol 14:329-40 (2004)
DOI:10.1016/j.semcancer.2004.04.012
Reference
  Authors
Wu L, Griffin JD.
  Title
Modulation of Notch signaling by mastermind-like (MAML) transcriptional co-activators and their involvement in tumorigenesis.
  Journal
Semin Cancer Biol 14:348-56 (2004)
DOI:10.1016/j.semcancer.2004.04.014
Reference
  Authors
Tsukumo S, Yasutomo K.
  Title
Notch governing mature T cell differentiation.
  Journal
J Immunol 173:7109-13 (2004)
DOI:10.4049/jimmunol.173.12.7109
Reference
  Authors
Haltiwanger RS.
  Title
Regulation of signal transduction pathways in development by glycosylation.
  Journal
Curr Opin Struct Biol 12:593-8 (2002)
DOI:10.1016/S0959-440X(02)00371-8
Reference
  Authors
Koo EH, Kopan R.
  Title
Potential role of presenilin-regulated signaling pathways in sporadic neurodegeneration.
  Journal
Nat Med 10 Suppl:S26-33 (2004)
DOI:10.1038/nm1065
Reference
  Authors
Okano H, Imai T, Okabe M.
  Title
Musashi: a translational regulator of cell fate.
  Journal
J Cell Sci 115:1355-9 (2002)
Reference
  Authors
Haltiwanger RS, Stanley P.
  Title
Modulation of receptor signaling by glycosylation: fringe is an O-fucose-beta1,3-N-acetylglucosaminyltransferase.
  Journal
Biochim Biophys Acta 1573:328-35 (2002)
DOI:10.1016/S0304-4165(02)00400-2
Reference
  Authors
Das G, Reynolds-Kenneally J, Mlodzik M.
  Title
The atypical cadherin Flamingo links Frizzled and Notch signaling in planar polarity establishment in the Drosophila eye.
  Journal
Dev Cell 2:655-66 (2002)
DOI:10.1016/S1534-5807(02)00147-8
Reference
  Authors
Cooper MT, Bray SJ.
  Title
Frizzled regulation of Notch signalling polarizes cell fate in the Drosophila eye.
  Journal
Nature 397:526-30 (1999)
DOI:10.1038/17395
Reference
  Authors
Tanigaki K, Kuroda K, Han H, Honjo T.
  Title
Regulation of B cell development by Notch/RBP-J signaling.
  Journal
Semin Immunol 15:113-9 (2003)
DOI:10.1016/S1044-5323(03)00008-3
KO pathway
ko04330   

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