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Description |
The Notch signaling pathway is an evolutionarily conserved, intercellular signaling mechanism essential for proper embryonic development in all metazoan organisms in the Animal kingdom. The Notch proteins (Notch1-Notch4 in vertebrates) are single-pass receptors that are activated by the Delta (or Delta-like) and Jagged/Serrate families of membrane-bound ligands. They are transported to the plasma membrane as cleaved, but otherwise intact polypeptides. Interaction with ligand leads to two additional proteolytic cleavages that liberate the Notch intracellular domain (NICD) from the plasma membrane. The NICD translocates to the nucleus, where it forms a complex with the DNA binding protein CSL, displacing a histone deacetylase (HDAc)-co-repressor (CoR) complex from CSL. Components of an activation complex, such as MAML1 and histone acetyltransferases (HATs), are recruited to the NICD-CSL complex, leading to the transcriptional activation of Notch target genes.
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Environmental Information Processing; Signal transduction
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Pathway map |

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Disease |
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Other DBs |
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Reference |
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Authors |
Hansson EM, Lendahl U, Chapman G. |
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Notch signaling in development and disease. |
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Reference |
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Authors |
Callahan R, Egan SE. |
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Notch signaling in mammary development and oncogenesis. |
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Reference |
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Authors |
Zweidler-McKay PA, Pear WS. |
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Notch and T cell malignancy. |
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Reference |
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Authors |
Wu L, Griffin JD. |
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Modulation of Notch signaling by mastermind-like (MAML) transcriptional co-activators and their involvement in tumorigenesis. |
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Reference |
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Authors |
Tsukumo S, Yasutomo K. |
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Notch governing mature T cell differentiation. |
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Reference |
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Authors |
Haltiwanger RS. |
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Regulation of signal transduction pathways in development by glycosylation. |
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Reference |
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Authors |
Koo EH, Kopan R. |
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Potential role of presenilin-regulated signaling pathways in sporadic neurodegeneration. |
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Reference |
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Authors |
Okano H, Imai T, Okabe M. |
Title |
Musashi: a translational regulator of cell fate. |
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J Cell Sci 115:1355-9 (2002) |
Reference |
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Authors |
Haltiwanger RS, Stanley P. |
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Modulation of receptor signaling by glycosylation: fringe is an O-fucose-beta1,3-N-acetylglucosaminyltransferase. |
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Reference |
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Authors |
Das G, Reynolds-Kenneally J, Mlodzik M. |
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The atypical cadherin Flamingo links Frizzled and Notch signaling in planar polarity establishment in the Drosophila eye. |
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Reference |
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Authors |
Cooper MT, Bray SJ. |
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Frizzled regulation of Notch signalling polarizes cell fate in the Drosophila eye. |
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Reference |
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Authors |
Tanigaki K, Kuroda K, Han H, Honjo T. |
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Regulation of B cell development by Notch/RBP-J signaling. |
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Related pathway |
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KO pathway |
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