KEGG PATHWAY: map04360

PATHWAY: map04360

Entry

map04360                    Pathway

Name

Axon guidance

Description

Axon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are read by growth cone receptors, and signal transduction pathways downstream of these receptors converge onto the Rho GTPases to elicit changes in cytoskeletal organization that determine which way the growth cone will turn.

Class

Organismal Systems; Development and regeneration

Pathway map

map04360

Axon guidance

Other DBs

GO:

0007411

Reference

PMID:14682358

Authors

Guan KL, Rao Y.

Title

Signalling mechanisms mediating neuronal responses to guidance cues.

Journal

Nat Rev Neurosci 4:941-56 (2003)
DOI:10.1038/nrn1254

Reference

PMID:15630019

Authors

Govek EE, Newey SE, Van Aelst L.

Title

The role of the Rho GTPases in neuronal development.

Journal

Genes Dev 19:1-49 (2005)
DOI:10.1101/gad.1256405

Reference

PMID:12677003

Authors

Huber AB, Kolodkin AL, Ginty DD, Cloutier JF.

Title

Signaling at the growth cone: ligand-receptor complexes and the control of axon growth and guidance.

Journal

Annu Rev Neurosci 26:509-63 (2003)
DOI:10.1146/annurev.neuro.26.010302.081139

Reference

PMID:15818466

Authors

Negishi M, Oinuma I, Katoh H.

Title

Plexins: axon guidance and signal transduction.

Journal

Cell Mol Life Sci 62:1363-71 (2005)
DOI:10.1007/s00018-005-5018-2

Reference

PMID:15363605

Authors

Huot J.

Title

Ephrin signaling in axon guidance.

Journal

Prog Neuropsychopharmacol Biol Psychiatry 28:813-8 (2004)
DOI:10.1016/j.pnpbp.2004.05.025

Reference

PMID:11891122

Authors

Patel BN, Van Vactor DL.

Title

Axon guidance: the cytoplasmic tail.

Journal

Curr Opin Cell Biol 14:221-9 (2002)
DOI:10.1016/S0955-0674(02)00308-3

Reference

PMID:11687826

Authors

Yu TW, Bargmann CI.

Title

Dynamic regulation of axon guidance.

Journal

Nat Neurosci 4 Suppl:1169-76 (2001)
DOI:10.1038/nn748

Reference

PMID:12471249

Authors

Dickson BJ.

Title

Molecular mechanisms of axon guidance.

Journal

Science 298:1959-64 (2002)
DOI:10.1126/science.1072165

Reference

PMID:15960985

Authors

Barallobre MJ, Pascual M, Del Rio JA, Soriano E.

Title

The Netrin family of guidance factors: emphasis on Netrin-1 signalling.

Journal

Brain Res Brain Res Rev 49:22-47 (2005)
DOI:10.1016/j.brainresrev.2004.11.003

Reference

PMID:15084255

Authors

Sabatier C, Plump AS, Le Ma, Brose K, Tamada A, Murakami F, Lee EY, Tessier-Lavigne M.

Title

The divergent Robo family protein rig-1/Robo3 is a negative regulator of slit responsiveness required for midline crossing by commissural axons.

Journal

Cell 117:157-69 (2004)
DOI:10.1016/S0092-8674(04)00303-4

Reference

PMID:25374504

Authors

Fujita Y, Yamashita T

Title

Axon growth inhibition by RhoA/ROCK in the central nervous system.

Journal

Front Neurosci 8:338 (2014)
DOI:10.3389/fnins.2014.00338

Reference

PMID:17169551

Authors

Yamashita T, Mueller BK, Hata K

Title

Neogenin and repulsive guidance molecule signaling in the central nervous system.

Journal

Curr Opin Neurobiol 17:29-34 (2007)
DOI:10.1016/j.conb.2006.12.001

Reference

PMID:26651291

Authors

van Erp S, van den Heuvel DMA, Fujita Y, Robinson RA, Hellemons AJCGM, Adolfs Y, Van Battum EY, Blokhuis AM, Kuijpers M, Demmers JAA, Hedman H, Hoogenraad CC, Siebold C, Yamashita T, Pasterkamp RJ

Title

Lrig2 Negatively Regulates Ectodomain Shedding of Axon Guidance Receptors by ADAM Proteases.

Journal

Dev Cell 35:537-552 (2015)
DOI:10.1016/j.devcel.2015.11.008

Related
pathway

map04010

MAPK signaling pathway

map04060

Cytokine-cytokine receptor interaction

map04310

Wnt signaling pathway

map04810

Regulation of actin cytoskeleton

KO pathway

ko04360

All links

Chemical substance (1)   
   KEGG COMPOUND (1)   
Gene (186689)   
   KEGG ORTHOLOGY (128)   
   RefGene (186561)   
Literature (13)   
   PubMed (13)   
All databases (186703)   

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