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Description |
Cell adhesion molecules (CAMs) are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, embryogenesis, and development of neuronal tissue. There are four main groups: the integrin family, the immunoglobulin superfamily, selectins, and cadherins. Membrane proteins that mediate immune cell–cell interactions fall into different categories, namely those involved in antigen recognition, costimulation and cellular adhesion. Furthermore cell-cell adhesions are important for brain morphology and highly coordinated brain functions such as memory and learning. During early development of the nervous system, neurons elongate their axons towards their targets and establish and maintain synapses through formation of cell-cell adhesions. Cell-cell adhesions also underpin axon-axon contacts and link neurons with supporting schwann cells and oligodendrocytes.
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Environmental Information Processing; Signaling molecules and interaction
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Pathway map |

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Other DBs |
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Barclay AN. |
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Membrane proteins with immunoglobulin-like domains--a master superfamily of interaction molecules. |
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Authors |
Sharpe AH, Freeman GJ. |
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The B7-CD28 superfamily. |
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Grewal IS, Flavell RA. |
Title |
CD40 and CD154 in cell-mediated immunity. |
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Authors |
Dardalhon V, Schubart AS, Reddy J, Meyers JH, Monney L, Sabatos CA, Ahuja R, Nguyen K, Freeman GJ, Greenfield EA, Sobel RA, Kuchroo VK. |
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CD226 is specifically expressed on the surface of Th1 cells and regulates their expansion and effector functions. |
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Montoya MC, Sancho D, Vicente-Manzanares M, Sanchez-Madrid F. |
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Cell adhesion and polarity during immune interactions. |
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Authors |
Dejana E. |
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Endothelial cell-cell junctions: happy together. |
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Authors |
Bazzoni G. |
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The JAM family of junctional adhesion molecules. |
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Becker BF, Heindl B, Kupatt C, Zahler S. |
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Endothelial function and hemostasis. |
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Elangbam CS, Qualls CW Jr, Dahlgren RR. |
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Cell adhesion molecules--update. |
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Muller WA. |
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Leukocyte-endothelial-cell interactions in leukocyte transmigration and the inflammatory response. |
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Authors |
Yamagata M, Sanes JR, Weiner JA. |
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Synaptic adhesion molecules. |
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Ethell IM, Pasquale EB. |
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Molecular mechanisms of dendritic spine development and remodeling. |
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Benson DL, Schnapp LM, Shapiro L, Huntley GW. |
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Making memories stick: cell-adhesion molecules in synaptic plasticity. |
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Rosdahl JA, Mourton TL, Brady-Kalnay SM. |
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Protein kinase C delta (PKCdelta) is required for protein tyrosine phosphatase mu (PTPmu)-dependent neurite outgrowth. |
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Dunican DJ, Doherty P. |
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The generation of localized calcium rises mediated by cell adhesion molecules and their role in neuronal growth cone motility. |
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Girault JA, Peles E. |
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Development of nodes of Ranvier. |
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Arroyo EJ, Scherer SS. |
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On the molecular architecture of myelinated fibers. |
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Salzer JL. |
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Polarized domains of myelinated axons. |
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Irie K, Shimizu K, Sakisaka T, Ikeda W, Takai Y. |
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Roles and modes of action of nectins in cell-cell adhesion. |
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Nakanishi H, Takai Y. |
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Roles of nectins in cell adhesion, migration and polarization. |
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Authors |
Siu MK, Cheng CY. |
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Extracellular matrix: recent advances on its role in junction dynamics in the seminiferous epithelium during spermatogenesis. |
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Authors |
Lee NP, Cheng CY. |
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Adaptors, junction dynamics, and spermatogenesis. |
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Inagaki M, Irie K, Ishizaki H, Tanaka-Okamoto M, Morimoto K, Inoue E, Ohtsuka T, Miyoshi J, Takai Y. |
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Roles of cell-adhesion molecules nectin 1 and nectin 3 in ciliary body development. |
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Marthiens V, Gavard J, Lambert M, Mege RM. |
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Cadherin-based cell adhesion in neuromuscular development. |
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Krauss RS, Cole F, Gaio U, Takaesu G, Zhang W, Kang JS. |
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Close encounters: regulation of vertebrate skeletal myogenesis by cell-cell contact. |
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Related pathway |
map04610 | Complement and coagulation cascades |
map04660 | T cell receptor signaling pathway |
map04670 | Leukocyte transendothelial migration |
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KO pathway |
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