Entry |
|
Name |
T cell receptor signaling pathway
|
Description |
Activation of T lymphocytes is a key event for an efficient response of the immune system. It requires the involvement of the T-cell receptor (TCR) as well as costimulatory molecules such as CD28. Engagement of these receptors through the interaction with a foreign antigen associated with major histocompatibility complex molecules and CD28 counter-receptors B7.1/B7.2, respectively, results in a series of signaling cascades. These cascades comprise an array of protein-tyrosine kinases, phosphatases, GTP-binding proteins and adaptor proteins that regulate generic and specialised functions, leading to T-cell proliferation, cytokine production and differentiation into effector cells.
|
Class |
Organismal Systems; Immune system
|
Pathway map |
map04660 | T cell receptor signaling pathway |

|
Other DBs |
|
Reference |
|
Authors |
Chen L. |
Title |
Co-inhibitory molecules of the B7-CD28 family in the control of T-cell immunity. |
Journal |
|
Reference |
|
Authors |
Macian F. |
Title |
NFAT proteins: key regulators of T-cell development and function. |
Journal |
|
Reference |
|
Authors |
Berg LJ, Finkelstein LD, Lucas JA, Schwartzberg PL. |
Title |
Tec family kinases in T lymphocyte development and function. |
Journal |
|
Reference |
|
Authors |
Huang Y, Wange RL. |
Title |
T cell receptor signaling: beyond complex complexes. |
Journal |
|
Reference |
|
Authors |
Schmitz ML, Bacher S, Dienz O. |
Title |
NF-kappaB activation pathways induced by T cell costimulation. |
Journal |
|
Reference |
|
Authors |
Alegre ML, Frauwirth KA, Thompson CB. |
Title |
T-cell regulation by CD28 and CTLA-4. |
Journal |
|
Reference |
|
Authors |
Horejsi V, Zhang W, Schraven B. |
Title |
Transmembrane adaptor proteins: organizers of immunoreceptor signalling. |
Journal |
|
Reference |
|
Authors |
Baniyash M. |
Title |
TCR zeta-chain downregulation: curtailing an excessive inflammatory immune response. |
Journal |
|
Reference |
|
Authors |
Sechi AS, Wehland J. |
Title |
Interplay between TCR signalling and actin cytoskeleton dynamics. |
Journal |
|
Reference |
|
Authors |
Okkenhaug K, Vanhaesebroeck B. |
Title |
PI3K in lymphocyte development, differentiation and activation. |
Journal |
|
Reference |
|
Authors |
Palacios EH, Weiss A. |
Title |
Function of the Src-family kinases, Lck and Fyn, in T-cell development and activation. |
Journal |
|
Reference |
|
Authors |
Kane LP, Lin J, Weiss A. |
Title |
It's all Rel-ative: NF-kappaB and CD28 costimulation of T-cell activation. |
Journal |
|
Reference |
|
Authors |
Acuto O, Michel F. |
Title |
CD28-mediated co-stimulation: a quantitative support for TCR signalling. |
Journal |
|
Reference |
|
Authors |
Finkelstein LD, Schwartzberg PL. |
Title |
Tec kinases: shaping T-cell activation through actin. |
Journal |
|
Reference |
|
Authors |
Duan L, Reddi AL, Ghosh A, Dimri M, Band H. |
Title |
The Cbl family and other ubiquitin ligases: destructive forces in control of antigen receptor signaling. |
Journal |
|
Reference |
|
Authors |
Schrum AG, Turka LA, Palmer E. |
Title |
Surface T-cell antigen receptor expression and availability for long-term antigenic signaling. |
Journal |
|
Reference |
|
Authors |
Smith-Garvin JE, Koretzky GA, Jordan MS |
Title |
T cell activation. |
Journal |
|
Reference |
|
Authors |
Diehn M, Alizadeh AA, Rando OJ, Liu CL, Stankunas K, Botstein D, Crabtree GR, Brown PO |
Title |
Genomic expression programs and the integration of the CD28 costimulatory signal in T cell activation. |
Journal |
|
Reference |
|
Authors |
Blonska M, Lin X |
Title |
CARMA1-mediated NF-kappaB and JNK activation in lymphocytes. |
Journal |
|
Reference |
|
Authors |
Rebeaud F, Hailfinger S, Thome M |
Title |
Dlgh1 and Carma1 MAGUK proteins contribute to signal specificity downstream of TCR activation. |
Journal |
|
Reference |
|
Authors |
Ashwell JD |
Title |
The many paths to p38 mitogen-activated protein kinase activation in the immune system. |
Journal |
|
Reference |
|
Authors |
Round JL, Humphries LA, Tomassian T, Mittelstadt P, Zhang M, Miceli MC |
Title |
Scaffold protein Dlgh1 coordinates alternative p38 kinase activation, directing T cell receptor signals toward NFAT but not NF-kappaB transcription factors. |
Journal |
|
Related pathway |
map04810 | Regulation of actin cytoskeleton |
|
KO pathway |
|