Entry |
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Name |
B cell receptor signaling pathway
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Description |
B cells are an important component of adaptive immunity. They produce and secrete millions of different antibody molecules, each of which recognizes a different (foreign) antigen. The B cell receptor (BCR) is an integral membrane protein complex that is composed of two immunoglobulin (Ig) heavy chains, two Ig light chains and two heterodimers of Ig-alpha and Ig-beta. After BCR ligation by antigen, three main protein tyrosine kinases (PTKs) -the SRC-family kinase LYN, SYK and the TEC-family kinase BTK- are activated. Phosphatidylinositol 3-kinase (PI3K) and phospholipase C-gamma 2 (PLC-gamma 2) are important downstream effectors of BCR signalling. This signalling ultimately results in the expression of immediate early genes that further activate the expression of other genes involved in B cell proliferation, differentiation and Ig production as well as other processes.
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Class |
Organismal Systems; Immune system
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Pathway map |
map04662 | B cell receptor signaling pathway |

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Other DBs |
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Reference |
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Authors |
Niiro H, Clark EA. |
Title |
Regulation of B-cell fate by antigen-receptor signals. |
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Reference |
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Authors |
Kurosaki T. |
Title |
Genetic analysis of B cell antigen receptor signaling. |
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Reference |
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Authors |
Nitschke L. |
Title |
The role of CD22 and other inhibitory co-receptors in B-cell activation. |
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Reference |
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Authors |
Morgan BP, Marchbank KJ, Longhi MP, Harris CL, Gallimore AM. |
Title |
Complement: central to innate immunity and bridging to adaptive responses. |
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Reference |
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Authors |
Kurosaki T. |
Title |
Regulation of B-cell signal transduction by adaptor proteins. |
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Reference |
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Authors |
Nitschke L, Tsubata T. |
Title |
Molecular interactions regulate BCR signal inhibition by CD22 and CD72. |
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Reference |
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Authors |
Jumaa H, Hendriks RW, Reth M. |
Title |
B cell signaling and tumorigenesis. |
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Reference |
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Authors |
Rickert RC. |
Title |
Regulation of B lymphocyte activation by complement C3 and the B cell coreceptor complex. |
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Reference |
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Authors |
Zouali M, Sarmay G |
Title |
B lymphocyte signaling pathways in systemic autoimmunity: implications for pathogenesis and treatment. |
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Reference |
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Authors |
Chiles TC. |
Title |
Regulation and function of cyclin D2 in B lymphocyte subsets. |
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Reference |
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Authors |
Allam A, Marshall AJ |
Title |
Role of the adaptor proteins Bam32, TAPP1 and TAPP2 in lymphocyte activation. |
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Reference |
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Authors |
Gold MR |
Title |
To make antibodies or not: signaling by the B-cell antigen receptor. |
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Reference |
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Authors |
Fu C, Turck CW, Kurosaki T, Chan AC |
Title |
BLNK: a central linker protein in B cell activation. |
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Reference |
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Authors |
Okada T, Maeda A, Iwamatsu A, Gotoh K, Kurosaki T |
Title |
BCAP: the tyrosine kinase substrate that connects B cell receptor to phosphoinositide 3-kinase activation. |
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Reference |
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Authors |
Shinohara H, Maeda S, Watarai H, Kurosaki T |
Title |
IkappaB kinase beta-induced phosphorylation of CARMA1 contributes to CARMA1 Bcl10 MALT1 complex formation in B cells. |
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Related pathway |
map04610 | Complement and coagulation cascades |
map04810 | Regulation of actin cytoskeleton |
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KO pathway |
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