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Description |
Hippocampal long-term potentiation (LTP), a long-lasting increase in synaptic efficacy, is the molecular basis for learning and memory. Tetanic stimulation of afferents in the CA1 region of the hippocampus induces glutamate release and activation of glutamate receptors in dendritic spines. A large increase in [Ca2+]i resulting from influx through NMDA receptors leads to constitutive activation of CaM kinase II (CaM KII) . Constitutively active CaM kinase II phosphorylates AMPA receptors, resulting in potentiation of the ionic conductance of AMPA receptors. Early-phase LTP (E-LTP) expression is due, in part, to this phosphorylation of the AMPA receptor. It is hypothesized that postsynaptic Ca2+ increases generated through NMDA receptors activate several signal transduction pathways including the Erk/MAP kinase and cAMP regulatory pathways. The convergence of these pathways at the level of the CREB/CRE transcriptional pathway may increase expression of a family of genes required for late-phase LTP (L-LTP).
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Organismal Systems; Nervous system
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Pathway map |

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Authors |
Blitzer RD, Iyengar R, Landau EM. |
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Postsynaptic signaling networks: cellular cogwheels underlying long-term plasticity. |
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Soderling TR, Derkach VA. |
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Postsynaptic protein phosphorylation and LTP. |
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Authors |
Poser S, Storm DR. |
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Role of Ca2+-stimulated adenylyl cyclases in LTP and memory formation. |
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Authors |
Xia Z, Storm DR. |
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The role of calmodulin as a signal integrator for synaptic plasticity. |
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Purves D, Augustine GJ (ed). |
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Neuroscience |
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Sunderland, Mass.:Sinauer Associates (2004) |
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Authors |
Lynch MA. |
Title |
Long-term potentiation and memory. |
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Authors |
Kelly PT, Mackinnon RL 2nd, Dietz RV, Maher BJ, Wang J. |
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Postsynaptic IP3 receptor-mediated Ca2+ release modulates synaptic transmission in hippocampal neurons. |
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Authors |
Berridge MJ. |
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Neuronal calcium signaling. |
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Related pathway |
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KO pathway |
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