KEGG   PATHWAY: aje03440Help
Entry
aje03440                    Pathway                                

Name
Homologous recombination - Histoplasma capsulatum
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
BRITE hierarchy
Pathway map
aje03440  Homologous recombination
aje03440

Ortholog table
Other DBs
BSID: 698879
GO: 0000724
Organism
Histoplasma capsulatum [GN:aje]
Gene
HCAG_06081  hypothetical protein [KO:K10866] [EC:3.6.-.-]
HCAG_08365  double-strand break repair protein mus-23 [KO:K10865]
HCAG_02557  hypothetical protein [KO:K04728] [EC:2.7.11.1]
HCAG_03400  hypothetical protein [KO:K10881]
HCAG_01865  hypothetical protein [KO:K10958]
HCAG_02026  hypothetical protein [KO:K07466]
HCAG_01084  hypothetical protein [KO:K10739]
HCAG_03403  DNA repair protein RAD51 [KO:K04482]
HCAG_05612  hypothetical protein [KO:K10873]
HCAG_05262  DNA repair and recombination protein RAD54 [KO:K10875] [EC:3.6.4.-]
HCAG_06823  hypothetical protein [KO:K10877] [EC:3.6.4.-]
HCAG_06498  DNA polymerase delta catalytic subunit [KO:K02327] [EC:2.7.7.7]
HCAG_04248  hypothetical protein [KO:K02328]
HCAG_06512  hypothetical protein [KO:K03504]
HCAG_04928  hypothetical protein [KO:K03505]
HCAG_03727  hypothetical protein [KO:K10901] [EC:3.6.4.12]
HCAG_05320  DNA topoisomerase III [KO:K03165] [EC:5.99.1.2]
HCAG_06635  hypothetical protein [KO:K08991] [EC:3.1.22.-]
HCAG_00331  hypothetical protein [KO:K10882] [EC:3.1.22.-]
Reference
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators] Japanese
  Journal
Seikagaku 79:449-53 (2007)
Reference
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
Reference
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   

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