KEGG   PATHWAY: biu05330
Entry
biu05330                    Pathway                                

Name
Allograft rejection - Bos indicus (zebu cattle)
Description
Allograft rejection is the consequence of the recipient's alloimmune response to nonself antigens expressed by donor tissues. After transplantation of organ allografts, there are two pathways of antigen presentation. In the direct pathway, recipient T cells react to intact allogeneic MHC molecules expressed on the surface of donor cells. This pathway would activate host CD4 or CD8 T cells. In contrast, donor MHC molecules (and all other proteins) shed from the graft can be taken up by host APCs and presented to recipient T cells in the context of self-MHC molecules - the indirect pathway. Such presentation activates predominantly CD4 T cells. A direct cytotoxic T-cell attack on graft cells can be made only by T cells that recognize the graft MHC molecules directly. Nontheless, T cells with indirect allospecificity can contribute to graft rejection by activating macrophages, which cause tissue injury and fibrosis, and are also likely to be important in the development of an alloantibody response to graft.
Class
Human Diseases; Immune disease
Pathway map
biu05330  Allograft rejection
biu05330

Organism
Bos indicus (zebu cattle) [GN:biu]
Gene
109577067  BOLA class I histocompatibility antigen, alpha chain BL3-7-like isoform X1 [KO:K06751]
109577074  BOLA class I histocompatibility antigen, alpha chain BL3-6-like isoform X1 [KO:K06751]
109577076  BOLA class I histocompatibility antigen, alpha chain BL3-7-like isoform X1 [KO:K06751]
109577078  LOW QUALITY PROTEIN: BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751]
109577080  LOW QUALITY PROTEIN: BOLA class I histocompatibility antigen, alpha chain BL3-6-like [KO:K06751]
109577083  BOLA class I histocompatibility antigen, alpha chain BL3-7-like isoform X1 [KO:K06751]
109577088  BOLA class I histocompatibility antigen, alpha chain BL3-7 isoform X1 [KO:K06751]
109577113  LOW QUALITY PROTEIN: BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751]
109576723  LOW QUALITY PROTEIN: BOLA class I histocompatibility antigen, alpha chain BL3-6-like [KO:K06751]
109561936  H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1 [KO:K06751]
109576990  CD80; T-lymphocyte activation antigen CD80 [KO:K05412]
109554436  CD86; T-lymphocyte activation antigen CD86 isoform X1 [KO:K05413]
109569809  CD28; T-cell-specific surface glycoprotein CD28 [KO:K06470]
109564477  IL12A; interleukin-12 subunit alpha [KO:K05406]
109561305  IL12B; interleukin-12 subunit beta [KO:K05425]
109570480  tumor necrosis factor ligand superfamily member 6 [KO:K04389]
109570785  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
109579171  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
109553933  PRF1; perforin-1 [KO:K07818]
109575715  duodenase-1 isoform X1 [KO:K01353] [EC:3.4.21.79]
109575716  mast cell protease 1A-like [KO:K01353] [EC:3.4.21.79]
109575719  duodenase-1-like [KO:K01353] [EC:3.4.21.79]
109575720  duodenase-1-like [KO:K01353] [EC:3.4.21.79]
109575204  LOW QUALITY PROTEIN: mast cell protease 3-like [KO:K01353] [EC:3.4.21.79]
109575773  duodenase-1 [KO:K01353] [EC:3.4.21.79]
109575279  granzyme B-like [KO:K01353] [EC:3.4.21.79]
109576545  DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
109576596  HLA class II histocompatibility antigen, DO alpha chain-like isoform X1 [KO:K06752]
109577038  SLA class II histocompatibility antigen, DQ haplotype D alpha chain-like [KO:K06752]
109577039  SLA class II histocompatibility antigen, DQ haplotype D alpha chain [KO:K06752]
109577041  LOW QUALITY PROTEIN: DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
109577042  HLA class II histocompatibility antigen, DR alpha chain [KO:K06752]
109576666  DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
109577307  LOW QUALITY PROTEIN: HLA class II histocompatibility antigen, DM alpha chain [KO:K06752]
109577316  HLA class II histocompatibility antigen, DM beta chain isoform X1 [KO:K06752]
109576780  SLA class II histocompatibility antigen, DQ haplotype D alpha chain-like [KO:K06752]
109571028  IL2; interleukin-2 [KO:K05429]
109555532  CD40LG; CD40 ligand [KO:K03161]
109567510  CD40; tumor necrosis factor receptor superfamily member 5 isoform X1 [KO:K03160]
109558719  IFNG; interferon gamma [KO:K04687]
109577428  TNF; tumor necrosis factor [KO:K03156]
109561213  IL4; interleukin-4 [KO:K05430]
109561216  IL5; interleukin-5 [KO:K05428]
109570808  IL10; interleukin-10 [KO:K05443]
Compound
C00533  Nitric oxide
Reference
  Authors
Arakelov A, Lakkis FG.
  Title
The alloimmune response and effector mechanisms of allograft rejection.
  Journal
Semin Nephrol 20:95-102 (2000)
Reference
  Authors
Le Moine A, Goldman M, Abramowicz D.
  Title
Multiple pathways to allograft rejection.
  Journal
Transplantation 73:1373-81 (2002)
DOI:10.1097/00007890-200205150-00001
Reference
  Authors
Trivedi HL.
  Title
Immunobiology of rejection and adaptation.
  Journal
Transplant Proc 39:647-52 (2007)
DOI:10.1016/j.transproceed.2007.01.047
Reference
  Authors
Pietra BA.
  Title
Transplantation immunology 2003: simplified approach.
  Journal
Pediatr Clin North Am 50:1233-59 (2003)
DOI:10.1016/S0031-3955(03)00119-6
Reference
PMID:8835634
  Authors
Oka T, Yoshimura N.
  Title
Immunosuppression in organ transplantation.
  Journal
Jpn J Pharmacol 71:89-100 (1996)
DOI:10.1254/jjp.71.89
Reference
  Authors
Sayegh MH.
  Title
Why do we reject a graft? Role of indirect allorecognition in graft rejection.
  Journal
Kidney Int 56:1967-79 (1999)
DOI:10.1046/j.1523-1755.1999.00751.x
Reference
  Authors
Benichou G.
  Title
Direct and indirect antigen recognition: the pathways to allograft immune rejection.
  Journal
Front Biosci 4:D476-80 (1999)
DOI:10.2741/benichou
Reference
  Authors
Turvey SE, Wood KJ.
  Title
Immunobiology of solid organ transplantation.
  Journal
Int Surg 84:279-90 (1999)
Reference
  Authors
Janeway CA, Travers P, Walport M, Shlomchik MJ.
  Title
Immunobiology 6th edition
  Journal
Garland Science Publishing (2005)
Reference
  Authors
Game DS, Lechler RI.
  Title
Pathways of allorecognition: implications for transplantation tolerance.
  Journal
Transpl Immunol 10:101-8 (2002)
DOI:10.1016/S0966-3274(02)00055-2
Reference
  Authors
Lechler RI, Garden OA, Turka LA.
  Title
The complementary roles of deletion and regulation in transplantation tolerance.
  Journal
Nat Rev Immunol 3:147-58 (2003)
DOI:10.1038/nri1002
Related
pathway
biu04210  Apoptosis
biu04514  Cell adhesion molecules
biu04610  Complement and coagulation cascades
biu04612  Antigen processing and presentation
biu04660  T cell receptor signaling pathway
biu04662  B cell receptor signaling pathway
KO pathway
ko05330   

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