KEGG   PATHWAY: bps03070
Entry
bps03070                    Pathway                                
Name
Bacterial secretion system - Burkholderia pseudomallei K96243
Description
Gram-negative bacteria secrete a wide range of proteins whose functions include biogenesis of organelles, such as pilli and flagella, nutrient acquisition, virulence, and efflux of drugs and other toxins. Six distinct secretion systems have been shown to mediate protein export through the inner and outer membranes of Gram-negative bacteria. These pathways are highly conserved throughout the Gram-negative bacterial species. In Gram-positive bacteria, secreted proteins are commonly translocated across the single membrane by the Sec pathway or the two-arginine (Tat) pathway.
Class
Environmental Information Processing; Membrane transport
Pathway map
bps03070  Bacterial secretion system
bps03070

Other DBs
GO: 0030253 0015628 0030254 0030255 0046819 0033103 0044098 0043952 0043953
Organism
Burkholderia pseudomallei K96243 [GN:bps]
Gene
BPSS1287  putative outer membrane efflux protein [KO:K12340]
BPSL3094  putative outer membrane bacteriocin efflux protein [KO:K12340]
BPSS1548  Type III secretion system protein [KO:K03221]
BPSS1390  sctC; putative type III secretion system protein [KO:K03219]
BPSS1592  putative type III secretion system protein [KO:K03219]
BPSS1397  sctJ; putative type III secretion associated protein [KO:K03222]
BPSS1624  putative type III secretion protein [KO:K03222]
BPSS1404  sctR; putative type III secretion-associated protein [KO:K03226]
BPSS1617  putative type III secretion protein [KO:K03226]
BPSS1405  sctS; putative type III secretion-associated protein [KO:K03227]
BPSS1616  putative type III secretion protein [KO:K03227]
BPSS1392  sctT; putative type III secretion-associated protein [KO:K03228]
BPSS1629  putative type III secretion protein [KO:K03228]
BPSS1400  sctU; putative type III secretion-associated protein [KO:K03229]
BPSS1621  putative type III secretion protein [KO:K03229]
BPSS1401  sctV; putative type III secretion-associated protein [KO:K03230]
BPSS1543  bsaQ; Type III secretion system protein [KO:K03230]
BPSS1620  putative type III secretion protein [KO:K03230]
BPSS1394  sctN; putative type III secretion associated protein [KO:K03224] [EC:7.4.2.8]
BPSS1627  putative type III secretion protein [KO:K03224] [EC:7.4.2.8]
BPSS1403  sctQ; putative type III secretion-associated protein [KO:K03225]
BPSS1538  bsaV; surface presentation of antigens protein [KO:K03225]
BPSS1618  putative type III secretion protein [KO:K03225]
BPSS1395  sctL; putative type III secretion-associated protein [KO:K03223]
BPSS1626  putative type III secretion protein [KO:K03223]
BPSL0007  gspD; general secretory pathway protein D [KO:K02453]
BPSL0010  gspC; putative general secretory pathway protein [KO:K02452]
BPSL0009  gspF; general secretory pathway protein F [KO:K02455]
BPSL0011  gspG; general secretory pathway protein G [KO:K02456]
BPSL0012  gspH; general secretory pathway protein H [KO:K02457]
BPSL0013  gspI; general secretory pathway protein I [KO:K02458]
BPSL0014  gspJ; general secretory pathway protein J [KO:K02459]
BPSL0015  gspK; general secretory pathway protein K [KO:K02460]
BPSL0016  gspL; general secretory pathway protein L [KO:K02461]
BPSL0017  gspM; general secretory pathway protein M [KO:K02462]
BPSL0008  gspE; general secretory pathway protein E [KO:K02454] [EC:7.4.2.8]
BPSL2871  secD; putative protein-export membrane protein [KO:K03072]
BPSL2872  secF; putative protein-export membrane protein [KO:K03074]
BPSL3227  secE; preprotein translocase SecE subunit [KO:K03073]
BPSL1210  secG; general secretory pathway, protein-export membrane protein [KO:K03075]
BPSL3193  secY; preprotein translocase SecY subunit [KO:K03076]
BPSL2870  putative membrane protein [KO:K03210]
BPSL0078  putative membrane protein [KO:K03217]
BPSL3016  secA; preprotein translocase SecA subunit [KO:K03070] [EC:7.4.2.8]
BPSL0514  putative cell division protein [KO:K03110]
BPSL0446  secB; protein-export protein [KO:K03071]
BPSL2995  ffh; signal recognition particle protein [KO:K03106] [EC:3.6.5.4]
BPSL3128  tatA; Sec-independent protein translocase protein TatA [KO:K03116]
BPSL3127  tatB; Sec-independent protein translocase protein TatB [KO:K03117]
BPSL3126  tatC; Sec-independent protein translocase protein TatC [KO:K03118]
BPSS0524  conserved hypothetical protein [KO:K11904]
BPSS0958  conserved hypothetical protein [KO:K11904]
BPSS1503  hypothetical protein [KO:K11904]
BPSS0181  conserved hypothetical protein [KO:K11904]
BPSS2056  conserved hypothetical protein [KO:K11904]
BPSS2093  conserved hypothetical protein [KO:K11904]
BPSS0105  conserved hypothetical protein [KO:K11904]
BPSS0523  conserved hypothetical protein [KO:K11904]
BPSS0078  conserved hypothetical protein [KO:K11904]
BPSL2046  conserved hypothetical protein [KO:K11904]
BPSS1498  conserved hypothetical protein [KO:K11903]
BPSS0099  conserved hypothetical protein [KO:K11903]
BPSL3105  conserved hypothetical protein [KO:K11903]
BPSS0171  conserved hypothetical protein [KO:K11903]
BPSS0518  conserved hypothetical protein [KO:K11903]
BPSL3109  putative lipoprotein [KO:K11906]
BPSS0100  putative exported protein [KO:K11906]
BPSS2107  putative exported protein [KO:K11906]
BPSS0170  putative lipoprotein [KO:K11906]
BPSS0529  putative lipoprotein [KO:K11906]
BPSS1511  putative membrane protein [KO:K11891]
BPSL3097  putative membrane protein [KO:K11891]
BPSS0167  putative membrane protein [KO:K11891]
BPSS0103  putative membrane protein [KO:K11891]
BPSS2104  putative membrane protein [KO:K11891]
BPSS0532  putative membrane protein [KO:K11891]
BPSS2105  putative outer membrane porin protein [KO:K11892]
BPSS0102  OmpA family membrane protein [KO:K11892]
BPSS0168  OmpA family membrane protein [KO:K11892]
BPSS1510  putative membrane protein [KO:K11892]
BPSL3111  putative membrane protein [KO:K11892]
BPSS0095  putative membrane protein [KO:K11892]
BPSS0531  OmpA-family membrane protein [KO:K11892]
BPSL3101  clpB; protease associated ATPase ClpB [KO:K11907]
BPSS2094  putative Clp protease ATPase [KO:K11907]
BPSS1502  putative Clp-type ATPase chaperone protein [KO:K11907]
BPSS0522  putative ATPase [KO:K11907]
BPSS0174  putative chaperone [KO:K11907]
BPSS0116  putative chaperone-related protein [KO:K11907]
Compound
C00002  ATP
Reference
PMID:11173102
  Authors
Kim JF.
  Title
Revisiting the chlamydial type III protein secretion system: clues to the origin of type III protein secretion.
  Journal
Trends Genet 17:65-9 (2001)
DOI:10.1016/S0168-9525(00)02175-2
Reference
PMID:11309112
  Authors
Plano GV, Day JB, Ferracci F.
  Title
Type III export: new uses for an old pathway.
  Journal
Mol Microbiol 40:284-93 (2001)
DOI:10.1046/j.1365-2958.2001.02354.x
Reference
PMID:11413015
  Authors
Gauthier A, Finlay BB.
  Title
Bacterial pathogenesis: the answer to virulence is in the pore.
  Journal
Curr Biol 11:R264-7 (2001)
DOI:10.1016/S0960-9822(01)00134-8
Reference
PMID:10047550
  Authors
Burns DL.
  Title
Biochemistry of type IV secretion.
  Journal
Curr Opin Microbiol 2:25-9 (1999)
DOI:10.1016/S1369-5274(99)80004-6
Reference
PMID:10920394
  Authors
Christie PJ, Vogel JP.
  Title
Bacterial type IV secretion: conjugation systems adapted to deliver effector molecules to host cells.
  Journal
Trends Microbiol 8:354-60 (2000)
DOI:10.1016/S0966-842X(00)01792-3
Reference
PMID:11309113
  Authors
Christie PJ.
  Title
Type IV secretion: intercellular transfer of macromolecules by systems ancestrally related to conjugation machines.
  Journal
Mol Microbiol 40:294-305 (2001)
DOI:10.1046/j.1365-2958.2001.02302.x
Reference
PMID:10481178
  Authors
Nunn D.
  Title
Bacterial type II protein export and pilus biogenesis: more than just homologies?
  Journal
Trends Cell Biol 9:402-8 (1999)
DOI:10.1016/S0962-8924(99)01634-7
Reference
PMID:11309111
  Authors
Sandkvist M.
  Title
Biology of type II secretion.
  Journal
Mol Microbiol 40:271-83 (2001)
DOI:10.1046/j.1365-2958.2001.02403.x
Reference
PMID:11349009
  Authors
Sandkvist M.
  Title
Type II secretion and pathogenesis.
  Journal
Infect Immun 69:3523-35 (2001)
DOI:10.1128/IAI.69.6.3523-3535.2001
Reference
PMID:15546664
  Authors
Delepelaire P
  Title
Type I secretion in gram-negative bacteria.
  Journal
Biochim Biophys Acta 1694:149-61 (2004)
DOI:10.1016/j.bbamcr.2004.05.001
Reference
PMID:18406342
  Authors
Hazes B, Frost L
  Title
Towards a systems biology approach to study type II/IV secretion systems.
  Journal
Biochim Biophys Acta 1778:1839-50 (2008)
DOI:10.1016/j.bbamem.2008.03.011
Reference
PMID:16448494
  Authors
Johnson TL, Abendroth J, Hol WG, Sandkvist M
  Title
Type II secretion: from structure to function.
  Journal
FEMS Microbiol Lett 255:175-86 (2006)
DOI:10.1111/j.1574-6968.2006.00102.x
Reference
PMID:15546665
  Authors
Filloux A
  Title
The underlying mechanisms of type II protein secretion.
  Journal
Biochim Biophys Acta 1694:163-79 (2004)
DOI:10.1016/j.bbamcr.2004.05.003
Reference
PMID:19396170
  Authors
Spreter T, Yip CK, Sanowar S, Andre I, Kimbrough TG, Vuckovic M, Pfuetzner RA, Deng W, Yu AC, Finlay BB, Baker D, Miller SI, Strynadka NC
  Title
A conserved structural motif mediates formation of the periplasmic rings in the type III secretion system.
  Journal
Nat Struct Mol Biol 16:468-76 (2009)
DOI:10.1038/nsmb.1603
Reference
PMID:15590783
  Authors
Ghosh P
  Title
Process of protein transport by the type III secretion system.
  Journal
Microbiol Mol Biol Rev 68:771-95 (2004)
DOI:10.1128/MMBR.68.4.771-795.2004
Reference
PMID:12360191
  Authors
Cornelis GR
  Title
The Yersinia Ysc-Yop 'type III' weaponry.
  Journal
Nat Rev Mol Cell Biol 3:742-52 (2002)
DOI:10.1038/nrm932
Reference
PMID:17215876
  Authors
Baron C
  Title
VirB8: a conserved type IV secretion system assembly factor and drug target.
  Journal
Biochem Cell Biol 84:890-9 (2006)
DOI:10.1139/o06-148
Reference
PMID:17943123
  Authors
Kwok T, Zabler D, Urman S, Rohde M, Hartig R, Wessler S, Misselwitz R, Berger J, Sewald N, Konig W, Backert S
  Title
Helicobacter exploits integrin for type IV secretion and kinase activation.
  Journal
Nature 449:862-6 (2007)
DOI:10.1038/nature06187
Reference
PMID:16092524
  Authors
Christie PJ, Cascales E
  Title
Structural and dynamic properties of bacterial type IV secretion systems (review).
  Journal
Mol Membr Biol 22:51-61 (2005)
DOI:10.1080/09687860500063316
Reference
PMID:15546668
  Authors
Christie PJ
  Title
Type IV secretion: the Agrobacterium VirB/D4 and related conjugation systems.
  Journal
Biochim Biophys Acta 1694:219-34 (2004)
DOI:10.1016/j.bbamcr.2004.02.013
Reference
PMID:15590781
  Authors
Henderson IR, Navarro-Garcia F, Desvaux M, Fernandez RC, Ala'Aldeen D
  Title
Type V protein secretion pathway: the autotransporter story.
  Journal
Microbiol Mol Biol Rev 68:692-744 (2004)
DOI:10.1128/MMBR.68.4.692-744.2004
Reference
PMID:9778731
  Authors
Henderson IR, Navarro-Garcia F, Nataro JP
  Title
The great escape: structure and function of the autotransporter proteins.
  Journal
Trends Microbiol 6:370-8 (1998)
DOI:10.1016/S0966-842X(98)01318-3
Reference
PMID:18524912
  Authors
Filloux A, Hachani A, Bleves S
  Title
The bacterial type VI secretion machine: yet another player for protein transport across membranes.
  Journal
Microbiology 154:1570-83 (2008)
DOI:10.1099/mic.0.2008/016840-0
Reference
PMID:19251641
  Authors
Leiman PG, Basler M, Ramagopal UA, Bonanno JB, Sauder JM, Pukatzki S, Burley SK, Almo SC, Mekalanos JJ
  Title
Type VI secretion apparatus and phage tail-associated protein complexes share a common evolutionary origin.
  Journal
Proc Natl Acad Sci U S A 106:4154-9 (2009)
DOI:10.1073/pnas.0813360106
Reference
PMID:17603507
  Authors
Kulasekara HD, Miller SI
  Title
Threonine phosphorylation times bacterial secretion.
  Journal
Nat Cell Biol 9:734-6 (2007)
DOI:10.1038/ncb0707-734
Reference
PMID:18078384
  Authors
Driessen AJ, Nouwen N
  Title
Protein translocation across the bacterial cytoplasmic membrane.
  Journal
Annu Rev Biochem 77:643-67 (2008)
DOI:10.1146/annurev.biochem.77.061606.160747
Reference
PMID:14641032
  Authors
Pool MR
  Title
Getting to the membrane: how is co-translational protein targeting to the endoplasmic reticulum regulated?
  Journal
Biochem Soc Trans 31:1232-7 (2003)
DOI:10.1042/bst0311232
Reference
PMID:19299134
  Authors
Desvaux M, Hebraud M, Talon R, Henderson IR
  Title
Secretion and subcellular localizations of bacterial proteins: a semantic awareness issue.
  Journal
Trends Microbiol 17:139-45 (2009)
DOI:10.1016/j.tim.2009.01.004
Reference
PMID:15063851
  Authors
Nakatogawa H, Murakami A, Ito K
  Title
Control of SecA and SecM translation by protein secretion.
  Journal
Curr Opin Microbiol 7:145-50 (2004)
DOI:10.1016/j.mib.2004.01.001
KO pathway
ko03070   

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