KEGG   PATHWAY: bta03440Help
Entry
bta03440                    Pathway                                

Name
Homologous recombination - Bos taurus (cow)
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
BRITE hierarchy
Pathway map
bta03440  Homologous recombination
bta03440

Ortholog table
Module
bta_M00288  RPA complex [PATH:bta03440]
bta_M00291  MRN complex [PATH:bta03440]
bta_M00295  BRCA1-associated genome surveillance complex (BASC) [PATH:bta03440]
Other DBs
BSID: 84285
GO: 0000724
Organism
Bos taurus (cow) [GN:bta]
Gene
515765  SSBP1; single-stranded DNA-binding protein, mitochondrial precursor [KO:K03111]
788127  RAD50; DNA repair protein RAD50 [KO:K10866] [EC:3.6.-.-]
525093  MRE11; double-strand break repair protein MRE11A [KO:K10865]
522943  NBN; nibrin [KO:K10867]
526824  ATM; serine-protein kinase ATM [KO:K04728] [EC:2.7.11.1]
353120  BRCA1; breast cancer type 1 susceptibility protein homolog [KO:K10605] [EC:2.3.2.27]
530961  BARD1; BRCA1-associated RING domain protein 1 [KO:K10683]
512977  RBBP8; DNA endonuclease RBBP8 [KO:K20773] [EC:3.1.-.-]
783256  BRIP1; Fanconi anemia group J protein [KO:K15362] [EC:3.6.4.12]
540574  TOPBP1; DNA topoisomerase 2-binding protein 1 [KO:K10728]
504796  ABRAXAS1; BRCA1-A complex subunit Abraxas 1 [KO:K20774]
508607  UIMC1; BRCA1-A complex subunit RAP80 isoform 1 [KO:K20775]
504517  BABAM1; BRISC and BRCA1-A complex member 1 [KO:K20776]
614152  BABAM2; BRISC and BRCA1-A complex member 2 [KO:K12173]
519513  BRCC3; lys-63-specific deubiquitinase BRCC36 [KO:K11864] [EC:3.4.19.-]
507620  PALB2; partner and localizer of BRCA2 [KO:K10897]
507069  BRCA2; breast cancer type 2 susceptibility protein isoform X1 [KO:K08775]
767981  SEM1; 26S proteasome complex subunit SEM1 [KO:K10881]
101907965  26S proteasome complex subunit SEM1 [KO:K10881]
615896  SYCP3; synaptonemal complex protein 3 [KO:K19528]
504844  RPA1; replication protein A 70 kDa DNA-binding subunit [KO:K07466]
507912  RPA2; replication protein A 32 kDa subunit [KO:K10739]
512754  RPA3; replication protein A 14 kDa subunit [KO:K10740]
104971312  RPA4; LOW QUALITY PROTEIN: replication protein A 30 kDa subunit [KO:K10741]
514749  RAD51; DNA repair protein RAD51 homolog 1 [KO:K04482]
512897  RAD52; DNA repair protein RAD52 homolog [KO:K10873]
617007  RAD51B; DNA repair protein RAD51 homolog 2 [KO:K10869]
540886  RAD51C; DNA repair protein RAD51 homolog 3 [KO:K10870]
529507  RAD51D; DNA repair protein RAD51 homolog 4 [KO:K10871]
789410  XRCC2; DNA repair protein XRCC2 [KO:K10879]
768244  XRCC3; DNA repair protein XRCC3 [KO:K10880]
100140639  RAD54L; DNA repair and recombination protein RAD54-like [KO:K10875] [EC:3.6.4.-]
533414  RAD54B; DNA repair and recombination protein RAD54B [KO:K10877] [EC:3.6.4.-]
281990  POLD1; DNA polymerase delta catalytic subunit [KO:K02327] [EC:2.7.7.7]
281991  POLD2; DNA polymerase delta subunit 2 [KO:K02328]
537616  POLD3; DNA polymerase delta subunit 3 [KO:K03504]
617899  POLD4; DNA polymerase delta subunit 4 [KO:K03505]
534148  BLM; Bloom syndrome protein isoform X1 [KO:K10901] [EC:3.6.4.12]
527411  TOP3A; DNA topoisomerase 3-alpha [KO:K03165] [EC:5.99.1.2]
537418  TOP3B; DNA topoisomerase 3-beta-1 [KO:K03165] [EC:5.99.1.2]
528432  MUS81; crossover junction endonuclease MUS81 [KO:K08991] [EC:3.1.22.-]
100125299  EME1; crossover junction endonuclease EME1 [KO:K10882] [EC:3.1.22.-]
Reference
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators] Japanese
  Journal
Seikagaku 79:449-53 (2007)
Reference
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
Reference
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   

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